Nervous System

• 

  Subject Areas on Research

  • A genome end-game: understanding gene function in the nervous system. 
  • Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens. 
  • Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. 
  • Aspects of immunobiology and immunotherapy and uses of monoclonal antibodies and biologic immune modifiers in human gliomas. 
  • Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. 
  • Biochemical mechanisms of developmental neurotoxicity of methylmercury. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Cancer chemotherapy in older adults. A tolerability perspective. 
  • Causes of treatment failure with antiepileptic drugs vary over time. 
  • Characterizing activity-dependent processes with a piecewise exponential model. 
  • Chemical and pharmacokinetic considerations in structure-activity relationships: panel discussion. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris. 
  • Coumaphos: delayed neurotoxic effect following dermal administration in hens. 
  • Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior. 
  • Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort. 
  • Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. 
  • Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity. 
  • Delayed neurotoxicity from continous low-dose oral administration of leptophos to hens. 
  • Delayed neurotoxicity from long-term low-level topical administration of leptophos to the comb of hens. 
  • Delayed neurotoxicity of leptophos: toxic effects on the nervous system of hens. 
  • Determinants of poliovirus neurovirulence. 
  • Development of central and peripheral catecholaminergic systems in rats addicted perinatally to methadone. 
  • Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio). 
  • Developmental neurotoxicity of succeeding generations of insecticides. 
  • Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats. 
  • Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat. 
  • Does labor influence neonatal and neurodevelopmental outcomes of extremely-low-birth-weight infants who are born by cesarean delivery? 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Effect of antenatal treatment of maternal periodontitis on early childhood neurodevelopment. 
  • Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial. 
  • Effects of a dermal dose of S,S,S,-tri-n-butyl phosphorotrithioate on brain acetylcholinesterase, acid phosphatase, and 2',3'-cyclic nucleotide-3' phosphohydrolase and plasma butyrylcholinesterase in hens. 
  • Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations. 
  • Electrical recording with micro- and macroelectrodes from the cerebellum of man. 
  • Electromyographic, neuropathologic, and functional correlates in the cat as the result of tri-o-cresyl phosphate delayed neurotoxicity. 
  • Elimination of synapses in the developing nervous system. 
  • Elucidating the links between endocrine disruptors and neurodevelopment. 
  • Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. 
  • Expression of the homeobox genes Hox 2.1 and 2.6 during mouse development. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • Generation and characterization of Tmeff2 mutant mice. 
  • Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening. 
  • HNF-3 beta as a regulator of floor plate development. 
  • Highly-compliant, microcable neuroelectrodes fabricated from thin-film gold and PDMS. 
  • Image-guided procedures for intensity-modulated spinal radiosurgery. Technical note. 
  • Immunogenic determinants of a neuropathogenic murine leukemia virus. 
  • Immunohistochemical localization of netrin-1 in the embryonic chick nervous system. 
  • In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. 
  • Influence of cognitive reserve on neuropsychological functioning in asymptomatic human immunodeficiency virus-1 infection. 
  • Intraocular neurilemmoma arising from the posterior ciliary nerve in neurofibromatosis. Pathologic findings. 
  • Introduction to zebrafish: current discoveries and emerging technologies for neurobehavioral toxicology and teratology. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure? 
  • Is neural development Darwinian? 
  • Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats. 
  • Kainic acid: neurophysiological and neurotoxic actions. 
  • Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. 
  • Magnetic resonance microscopy of chick embryos in ovo. 
  • Mechanisms of joint neurotoxicity of n-hexane, methyl isobutyl ketone and O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens. 
  • Microbial colonization is required for normal neurobehavioral development in zebrafish. 
  • Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. 
  • Molecular and genetic approaches for the analysis of C. elegans neuronal development. 
  • Molecular clocks and the early evolution of metazoan nervous systems. 
  • Multiple elements may be used for regulation of the GAP-43 gene in different cell-types. 
  • Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. 
  • NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017. 
  • Nanoscale neuro-integrative coatings for neural implants. 
  • Natural history of severe decompression sickness after rapid ascent from air saturation in a porcine model. 
  • Naturally acquired leprosy-like disease in the nine-banded armadillo (Dasypus novemcinctus): histopathologic and microbiologic studies of tissues. 
  • Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? 
  • Neural Control of Inflammation: Implications for Perioperative and Critical Care. 
  • Neural development, genes and the epilepsies: introduction. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. 
  • Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish. 
  • Neuregulins as potential drugs for neurological disorders. 
  • Neurobehavioral changes with caudate lesions. 
  • Neurobehavioral toxicology of halothane in rats. 
  • Neurodevelopmental outcomes after cardiac surgery in infancy. 
  • Neurologic injury from undersea diving. 
  • Neurologic manifestations of tri-O-cresyl phosphate delayed neurotoxicity in cats. 
  • Neurological disorders with abnormalities of immunoglobulin metabolism. 
  • Neurotoxicity resulting from coexposure to pyridostigmine bromide, deet, and permethrin: implications of Gulf War chemical exposures. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Novel origins of lineage founder cells in the direct-developing sea urchin Heliocidaris erythrogramma. 
  • Ornithine decarboxylase as a tool in developmental neurobiology. 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. 
  • Pattern of neurotoxicity of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione alone and in combination with O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens. 
  • Pharmacokinetics of a neurotoxic oral dose of leptophos in hens. 
  • Pharmacology of recovery after stroke. 
  • Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila. 
  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. 
  • Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution. 
  • Psychosocial factors in the neurobiology of schizophrenia: a selective review. 
  • Recent progress in understanding the mechanisms of pain and itch. 
  • Receptors for abused drugs: development and plasticity. 
  • Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. 
  • Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors. 
  • Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. 
  • Sensitivity of the cat to delayed neurotoxicity induced by O-ethyl O-4-nitrophenyl phenylphosphonothioate. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Studies of dopamine pharmacology in molluscs. 
  • Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. 
  • Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems. 
  • The changing view of neural specificity. 
  • The crossroads of RNA regulation and function in neurodevelopment. 
  • The development of neuronal morphology in insects. 
  • The long-term effects of prenatal nicotine exposure on neurologic development. 
  • The neural signatures of distinct psychopathic traits. 
  • The neurobiological basis of epilepsy. 
  • The relative neurotoxicities of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione following oral or intraperitoneal administration in hens. 
  • The role of pharmacokinetics and metabolism in species sensitivity to neurotoxic agents. 
  • The role of protein phosphatases in synaptic transmission, plasticity and neuronal development. 
  • The uptake of methyl mercury (203Hg) in different tissues related to its neurotoxic effects. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • Three dimensional magnetic resonance microangiography of rat neurovasculature. 
  • Total parenteral nutrition. 
  • Toxicokinetics and metabolism of delayed neurotoxic organophosphorus esters. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis. 
  • Use of medaka in toxicity testing. 
  • Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. 
  • Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. 
  • [New evidence of the antigenic relation between the viruses of epidemic neuropathy and the human nervous system. A study of the immune cellular response in patients with epidemic neuropathy and controls. A review of the topic]. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Physics
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Schmehl, Meredith, Student, Neurobiology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship