Nervous System Diseases

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  Subject Areas on Research

  • "Other" neurologic complications after cardiac surgery. 
  • A model for slow axonal transport and its application to neurofilamentous neuropathies. 
  • A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia. 
  • Acquired immunodeficiency syndrome (AIDS). 
  • Acrylamide increases in vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins. 
  • Acupuncture application for neurological disorders. 
  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome. 
  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. 
  • Advances in pediatric neuroradiology: highlights of the recent medical literature. 
  • Adverse effects of FK 506 overdosage after liver transplantation. 
  • Amplification of HIV-1 provirus from cerebrospinal fluid and its correlation with neurologic disease. 
  • An Analysis of the Incidence and Outcomes of Major Versus Minor Neurological Decline After Complex Adult Spinal Deformity Surgery: A Subanalysis of Scoli-RISK-1 Study. 
  • Anticholinergic drugs and elderly people: a no brainer? 
  • Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. 
  • Apolipoprotein E genotype and S100beta after cardiac surgery: is inflammation the link? 
  • Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. 
  • Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. 
  • Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease. 
  • Assessment of the delayed neurotoxicity of tributyl phosphate, tributoxyethyl phosphate, and dibutylphenyl phosphate. 
  • Association between cyclosporin neurotoxicity and hypomagnesaemia. 
  • Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Autoimmunity and neurological disease: antibody modulation of synaptic transmission. 
  • Automatic analysis of the electromyographic interference pattern using the turns: amplitude ratio. 
  • Bartonella sp. bacteremia in patients with neurological and neurocognitive dysfunction. 
  • Brain stimulation in neurology and psychiatry: perspectives on an evolving field. 
  • Carbon monoxide poisoning. 
  • Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going? 
  • Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat. 
  • Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. 
  • Cardiovascular manifestations of neurologic disease. 
  • Characterization of delayed neurotoxicity in the mouse following chronic oral administration of tri-o-cresyl phosphate. 
  • Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Clinical trials in progressive neurological diseases. Recruitment, enrollment, retention and compliance. 
  • Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease. 
  • Collagenolytic activity of the skin associated with neuromuscular diseases including amyotrophic lateral sclerosis. 
  • Comorbidity of depression with other medical diseases in the elderly. 
  • Comparison of MRI and MRA findings in children with a variety of neurologic conditions. 
  • Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. 
  • Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing. 
  • Controlling robots with the mind. 
  • Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results. 
  • Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. 
  • Coumaphos: delayed neurotoxic effect following dermal administration in hens. 
  • Current best practices and guidelines. Assessment and management of complications in infective endocarditis. 
  • Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. 
  • Delayed neuropsychologic dysfunction after liver transplantation for acute liver failure: a matched, case-controlled study. 
  • Delayed neurotoxic, late acute and cholinergic effects of S,S,S-tributyl phosphorotrithioate (DEF): subchronic (90 days) administration in hens. 
  • Delayed neurotoxicity induced by organophosphorus compounds in the wild mallard duckling: effect of leptophos. 
  • Delayed neurotoxicity of O-ethyl O-2,4-dichlorophenyl phenylphosphonothioate: effects of a single oral dose on hens. 
  • Delayed neurotoxicity of O-ethyl O-4-nitrophenyl phenylphosphonothioate: subchronic (90 days) oral administration in hens. 
  • Delayed neurotoxicity of leptophos and related compounds: differential effects of subchronic oral administration of pure, technical grade and degradation products on the hen. 
  • Delayed neurotoxicity of subchronic oral administration of leptophos to hens: recovery during four months after exposure. 
  • Dentatorubral-pallidoluysian atrophy and Haw River syndrome. 
  • Depression in elderly hospitalized patients with medical illness. 
  • Detection of activated terminal complement (C5b-9) in cerebrospinal fluid from patients with central nervous system involvement of primary Sjogren's syndrome or systemic lupus erythematosus. 
  • Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders. 
  • Differential metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate by rat and chicken hepatic microsomes. 
  • Diisopropyl phosphorofluoridate (DFP) treatment alters calcium-activated proteinase activity and cytoskeletal proteins of the hen sciatic nerve. 
  • Distinct neurological disorders with ATP1A3 mutations. 
  • Domestic violence in neurologic practice. 
  • Duration of Adjuvant Chemotherapy for Stage III Colon Cancer. 
  • Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos. 
  • Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery. 
  • Effect of subchronic dermal application of O-ethyl O-4-nitrophenyl phenylphosphonothioate on producing delayed neurotoxicity in hens. 
  • Effects of a dermal dose of S,S,S,-tri-n-butyl phosphorotrithioate on brain acetylcholinesterase, acid phosphatase, and 2',3'-cyclic nucleotide-3' phosphohydrolase and plasma butyrylcholinesterase in hens. 
  • Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. 
  • Emerging targets in neuroinflammation-driven chronic pain. 
  • Errors in surgical neuropathology and the influence of cognitive biases: the psychology of intelligence analysis. 
  • Ethylmalonic aciduria: an organic acidemia with CNS involvement and vasculopathy. 
  • Evaluation of an automatic method of measuring features of motor unit action potentials. 
  • Evidence-based decision support for neurological diagnosis reduces errors and unnecessary workup. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system? 
  • Finding neuroelectric activity under magnetic-field oscillations (NAMO) with magnetic resonance imaging in vivo. 
  • Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. 
  • Generalized Periodic Discharges: A Topical Review. 
  • Genetic engineering of mesenchymal stem cells and its application in human disease therapy. 
  • Genetic models in pharmacology: present status and future. 
  • Genomics of human health and aging. 
  • Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. 
  • Head injuries. Initial evaluation and management. 
  • Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. 
  • High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance. 
  • Histopathological assessment of triphenyl phosphite neurotoxicity in the hen. 
  • Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. 
  • Hybrid procedures in the treatment of thoracoabdominal aortic aneurysms: a systematic review. 
  • Hyperbaric oxygen therapy for treatment of neurologic sequela after atrioesophageal fistula. 
  • Hypoglossal neuropathy in hereditary neuropathy with liability to pressure palsy. 
  • Hysterical conversion reactions mimicking neurological disease. 
  • IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection. 
  • Identification of a common epitope between enterovirus 71 and human MED25 proteins which may explain virus-associated neurological disease. 
  • Iliac artery pseudoaneurysm following renal transplantation presenting as lumbosacral plexopathy. 
  • Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab. 
  • Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. 
  • Incorporating Functional Information in Tests of Excess De Novo Mutational Load. 
  • Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. 
  • Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. 
  • Influenza vaccination practices of physicians and caregivers of children with neurologic and neurodevelopmental conditions - United States, 2011-12 influenza season. 
  • Interaction between neurotoxicities induced by organophosphorus and long-chain hexacarbon compounds. 
  • Interneurons from embryonic development to cell-based therapy. 
  • Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease. 
  • Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results. 
  • Isolated deficiency of vitamin E with progressive neurologic deterioration. 
  • Isolated sulfite oxidase deficiency: review of two cases in one family. 
  • Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. 
  • Lack of delayed neurotoxic effect after tri-o-cresyl phosphate treatment in male Fischer 344 rats: biochemical, neurobehavioral, and neuropathological studies. 
  • Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. 
  • Late onset of distinct neurologic syndromes in galactosemic siblings. 
  • Lhermitte's sign in cobalamin (vitamin B12) deficiency. 
  • Long-term efficacy of microvascular decompression in trigeminal neuralgia. 
  • Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. 
  • Macrophage markers in diagnostic neuropathology. 
  • Management of Sickle Cell Disease in Children. 
  • Mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II. 
  • Medical comorbidity in women and men with schizophrenia: a population-based controlled study. 
  • Microtubule transport defects in neurological and ciliary disease. 
  • Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine. 
  • Modified open-door laminoplasty for treatment of neurological deficits in younger patients with congenital spinal stenosis: analysis of clinical and radiographic data. 
  • Molybdenum cofactor deficiency associated with Dandy-Walker malformation. 
  • Mononeuropathies in pregnancy. 
  • Monosynaptic reflex depression in cats with organophosphorus neuropathy: effects of tri-o-cresyl phosphate. 
  • Morbidity and mortality in the surgical treatment of six hundred five pediatric patients with isthmic or dysplastic spondylolisthesis. 
  • More evidence for the benefits of cognitive activity over the lifespan. 
  • Mycobacterium tuberculosis polymerase chain reaction findings in neurosarcoidosis. 
  • Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (ANCA)-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis (Wegener's): Distinct Patient Subsets. 
  • NIH Neural Interfaces Workshop: August 21-23, 2006, Bethesda, MD, USA. 
  • NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies. 
  • Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures. 
  • Neuregulins as potential drugs for neurological disorders. 
  • Neurologic Deficits Have a Negative Impact on Patient-Related Outcomes in Primary Presentation Adult Symptomatic Lumbar Scoliosis Surgical Treatment at One-Year Follow-up. 
  • Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis. 
  • Neurologic intensive care unit monitoring. 
  • Neurologic manifestations of hematologic disease. 
  • Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage. 
  • Neurologic symptoms associated with raising poultry and swine among participants in the Agricultural Health Study. 
  • Neurological complications of cardiac surgery. 
  • Neurological disorders with abnormalities of immunoglobulin metabolism. 
  • Neurological signs in congenital iodine-deficiency disorder (endemic cretinism). 
  • Neurology and diving. 
  • Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. 
  • Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. 
  • Neuropeptides and neurotransmitters in Alzheimer's disease: focus on corticotrophin releasing factor. 
  • Neuroprotection in cardiac surgery. 
  • Neuropsychological performance at the age of 13 years and adult schizophreniform disorder: prospective birth cohort study. 
  • Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens. 
  • New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. 
  • No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. 
  • Nomogram for Predicting Time to Death After Withdrawal of Life-Sustaining Treatment in Patients With Devastating Neurological Injury. 
  • Nrf2, a multi-organ protector? 
  • Open heart surgery and cognitive decline. 
  • Organophosphorus ester-induced delayed neurotoxicity. 
  • Palliative care in neonatal neurology: robust support for infants, families and clinicians. 
  • Patient selection in congenital pyriform aperture stenosis repair - 14 year experience and systematic review of literature. 
  • Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications. 
  • Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. 
  • Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU) terminated by severe neurologic toxicity. 
  • Physician Beliefs about Physical and Mental Competency of Patients Applying for Concealed Weapon Permits. 
  • Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest. 
  • Postural hypotension. 
  • Predictors of Complications of Tonsillectomy With or Without Adenoidectomy in Hospitalized Children and Adolescents in the United States, 2001-2010: A Population-Based Study. 
  • Preimplantation genetic diagnosis for inherited neurological disorders. 
  • Propofol sedation for longitudinal pediatric neuroimaging research. 
  • Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. 
  • Psychotic symptoms in patients with medical disorders. 
  • Quiet time: a nursing intervention to promote sleep in neurocritical care units. 
  • Quinolinic acid in neurological disease: opportunities for novel drug discovery. 
  • Rates of new neurological deficit associated with spine surgery based on 108,419 procedures: a report of the scoliosis research society morbidity and mortality committee. 
  • Re: Transient lower extremity neurapraxia associated with radical perineal prostatectomy: a complication of the exaggerated lithotomy position. 
  • Reactive oxygen species: from health to disease. 
  • Recombinant DNA strategies in genetic neurological diseases. 
  • Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial. 
  • Rem sleep behavior disorder: potential relationship to post-traumatic stress disorder. 
  • Respiratory management in acute neurologic illness. 
  • Retrospective analysis underestimates neurological deficits in complex spinal deformity surgery: a Scoli-RISK-1 Study. 
  • Role of acid phosphatase in delayed neurotoxicity induced by leptophos in hens. 
  • Safeguards to prevent neurologic complications after epidural steroid injections: consensus opinions from a multidisciplinary working group and national organizations. 
  • Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. 
  • Sarin: health effects, metabolism, and methods of analysis. 
  • Short-term complications associated with surgery for high-grade spondylolisthesis in adults and pediatric patients: a report from the scoliosis research society morbidity and mortality database. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells. 
  • Survey of anesthesiologists practicing in American neurointensive care units as neurointensivists. 
  • Survey of health status and complications among propionic acidemia patients. 
  • Targeting RNA in mammalian systems with small molecules. 
  • Tear gas: an epidemiological and mechanistic reassessment. 
  • Temporal Changes in Prescription of Neuropharmacologic Drugs and Utilization of Resources Related to Neurologic Morbidity in Mechanically Ventilated Children With Bronchiolitis. 
  • Tethered cord due to spina bifida occulta presenting in adulthood: a tricenter review of 61 patients. 
  • The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity. 
  • The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury. 
  • The cytoskeleton as a target for organophosphorus ester-induced delayed neurotoxicity (OPIDN). 
  • The efficacy of endosaccular aneurysm occlusion in alleviating neurological deficits produced by mass effect. 
  • The endoplasmic reticulum and neurological diseases. 
  • The evolving role of gene-based treatment in surgery. 
  • The genetics of neuropsychiatric diseases: looking in and beyond the exome. 
  • The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens: potentiating effect. 
  • The new approach to assignment of ASFA categories--introduction to the fourth special issue: clinical applications of therapeutic apheresis. 
  • The status and future of acupuncture clinical research. 
  • The synergism of n-hexane-induced neurotoxicity by methyl isobutyl ketone following subchronic (90 days) inhalation in hens: induction of hepatic microsomal cytochrome P-450. 
  • The uptake of methyl mercury (203Hg) in different tissues related to its neurotoxic effects. 
  • The value of magnetic resonance imaging in the evaluation of fatty filum terminale. 
  • Therapy with bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma: final results of a phase II trial (CALGB 50501). 
  • Thoracoscopic sympathectomy in the management of vasomotor disturbances and complex regional pain syndrome of the hand. 
  • Toward a convergence of regenerative medicine, rehabilitation, and neuroprosthetics. 
  • Transcatheter occlusion of patent foramen ovale: a prevention for decompression illness? 
  • Transient lower extremity neurapraxia associated with radical perineal prostatectomy: a complication of the exaggerated lithotomy position. 
  • Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage. 
  • Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. 
  • Ultraviolet-light-inactivated Cas-Br-M murine leukemia virus induces a protective CD8+ cytotoxic T lymphocyte response in newborn mice. 
  • Updated European Heart Rhythm Association practical guide on the use of non-vitamin-K antagonist anticoagulants in patients with non-valvular atrial fibrillation: Executive summary. 
  • Use of extracorporeal life support in patients with congenital heart disease. 
  • Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. 
  • Using human neural stem cells to model neurological disease. 
  • Utility of postmortem magnetic resonance imaging in clinical neuropathology. 
  • Uveitis with neurological manifestations. 
  • Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat. 
  • Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease. 
  • Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. 
  • Work-site clinical and neurobehavioral assessment of solvent-exposed microelectronics workers. 
  • [Neurology and cardiology: points of contact]. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berger, Miles, Assistant Professor of Anesthesiology, Duke Science & Society
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, with tenure, School of Nursing
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Professor in Neuroscience, Biomedical Engineering
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology