Neural Crest

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  Subject Areas on Research

  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • Axenfeld-Rieger syndrome. A spectrum of developmental disorders. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Complex choristoma of the gyrus rectus: a distinct clinicopathologic entity? 
  • Developmental biology. The making of the ear. 
  • EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. 
  • Early development of the neural plate, neural crest and facial region of marsupials. 
  • Early differentiation and migration of cranial neural crest in the opossum, Monodelphis domestica. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Fgf8 is required for anterior heart field development. 
  • Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. 
  • Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. 
  • Intravital imaging of mouse embryos. 
  • J. P. Hill and Katherine Watson's studies of the neural crest in marsupials. 
  • Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 
  • Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. 
  • Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva. 
  • Nicotine evokes cell death in embryonic rat brain during neurulation. 
  • Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer. 
  • Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology. 
  • Posterior axial corneal malformation and uveoretinal angiodysgenesis--a neurocristopathy? 
  • Prevention of fumonisin B1-induced neural tube defects by folic acid. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. 
  • Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects. 
  • The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. 
  • The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. 
  • The genetic regulation of pigment cell development. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10. 
  • Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Silver, Debra Lynn, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society