Neural Inhibition

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  Subject Areas on Research

  • A GABAergic nigrotectal pathway for coordination of drinking behavior. 
  • A cortical filter that learns to suppress the acoustic consequences of movement. 
  • A perfusion chamber for the study of CNS physiology and pharmacology in vitro. 
  • Abnormal neuronal excitability in hippocampal slices from kindled rats. 
  • Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. 
  • Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. 
  • Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. 
  • Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium. 
  • Bang-bang control of feeding: Role of hypothalamic and satiety signals 
  • Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells. 
  • Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties. 
  • Biological functions of activity-dependent transcription revealed. 
  • Calcium channel function regulated by the SH3-GK module in beta subunits. 
  • Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. 
  • Changes in synaptic transmission produced by hydrogen peroxide. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Circuit mechanisms revealed by spike-timing correlations in macaque area MT. 
  • Common synaptic effects of pentylenetetrazol and penicillin. 
  • Complementary modulation of somatic inhibition by opioids and cannabinoids. 
  • Contributions of intrinsic membrane dynamics to fast network oscillations with irregular neuronal discharges. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Cortical plasticity induced by inhibitory neuron transplantation. 
  • Cultural influences on neural basis of inhibitory control. 
  • Delayed striate cortical activation during spatial attention. 
  • Developmental differences in the sensitivity of hippocampal GABAA receptor-mediated IPSCS to ethanol. 
  • Developmental differences in the sensitivity of spontaneous and miniature IPSCs to ethanol. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. 
  • Disinhibition in rat superior colliculus mediated by GABAc receptors. 
  • Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. 
  • Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat, Eptesicus fuscus. 
  • Diversity of neural responses in the brainstem during smooth pursuit eye movements constrains the circuit mechanisms of neural integration. 
  • Does epileptiform activity contribute to cognitive impairment in Alzheimer's disease? 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons. 
  • Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia. 
  • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. 
  • Electrophysiological activity underlying inhibitory control processes in normal adults. 
  • Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia. 
  • Enduring effects of adolescent drug exposure. 
  • Enhancement of whole cell synaptic currents by low osmolarity and by low [NaCl] in rat hippocampal slices. 
  • Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. 
  • Evidence for impaired cortical inhibition in patients with unipolar major depression. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Experimental partial epileptogenesis. 
  • Exploring the superior colliculus in vitro. 
  • Facilitation of the induction of long-term potentiation by GABAB receptors. 
  • Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Feed-forward inhibitory potentials and excitatory interactions in guinea-pig hippocampal pyramidal cells. 
  • Focal electrically administered seizure therapy: a novel form of ECT illustrates the roles of current directionality, polarity, and electrode configuration in seizure induction. 
  • Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures. 
  • GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. 
  • GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus. 
  • GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo. 
  • GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. 
  • Gain modulation by nicotine in macaque v1. 
  • Geniculocalcarine hyperintensities on brain magnetic resonance imaging associated with visual hallucinations in the elderly. 
  • Hidden complexity of synaptic receptive fields in cat V1. 
  • How noise affects the synchronization properties of recurrent networks of inhibitory neurons. 
  • Hypervigilance for fear after basolateral amygdala damage in humans. 
  • Identification of an elaborate complex mediating postsynaptic inhibition. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study. 
  • Impaired modulation of attention and emotion in schizophrenia. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory. 
  • Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. 
  • Inhibition, Not Excitation, Drives Rhythmic Whisking. 
  • Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC. 
  • Inhibitory controls of ingestion in 6-day-old rat pups. 
  • Inhibitory simple partial (non-convulsive) status epilepticus after intracranial surgery. 
  • Intentional false responding shares neural substrates with response conflict and cognitive control. 
  • Interactions of nigrostriate synaptic transmission, iontophoretic O-methylated phenethylamines, dopamine, apomorphine and acetylcholine. 
  • Interfering with inhibition may improve motor function. 
  • Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. 
  • Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity. 
  • Intrinsic and extrinsic contributions to auditory selectivity in a song nucleus critical for vocal plasticity. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • It's about time for thalamocortical circuits. 
  • Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. 
  • Lasting neuron depression induced by high potassium and its prevention by low calcium and NMDA receptor blockade. 
  • Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. 
  • Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. 
  • Low excitatory innervation balances high intrinsic excitability of immature dentate neurons. 
  • Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood. 
  • Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. 
  • Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition. 
  • Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. 
  • Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke. 
  • Model calculations of time dependent responses to binaural stimuli in the dorsal nucleus of the lateral lemniscus. 
  • Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Motor cortex excitability after vagus nerve stimulation in major depression. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Munc13-1 is required for presynaptic long-term potentiation. 
  • NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Network analysis of positron emission tomography regional cerebral blood flow data: ensemble inhibition during episodic memory retrieval. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. I. Changes in the responses of brain stem neurons. 
  • Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and control. 
  • Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. 
  • Neural correlates of learned song in the avian forebrain: simultaneous representation of self and others. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nonlinear signal transfer from mouse rods to bipolar cells and implications for visual sensitivity. 
  • On the distribution of firing rates in networks of cortical neurons. 
  • Opioid dysfunction and risk for hypertension: naloxone and blood pressure responses during different types of stress. 
  • Optimal information storage and the distribution of synaptic weights: perceptron versus Purkinje cell. 
  • Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections. 
  • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. 
  • Penicillin effects on iontophoretic responses in Aplysia californica. 
  • Peripheral nerve electrical stimulation. 
  • Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. 
  • Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. 
  • Pharmacological studies of a novel dopamine-sensitive receptor mediating burst-firing inhibition of neurosecretory cell R 15 in Aplysia californica. 
  • Pinning down response inhibition in the brain--conjunction analyses of the Stop-signal task. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Premonitory sensory phenomenon in Tourette's syndrome. 
  • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. 
  • Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current. 
  • Reflex effects and postsynaptic membrane potential changes during epileptiform activity induced by penicillin in decapitate spinal cords. 
  • Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. 
  • Responses during eye movements of brain stem neurons that receive monosynaptic inhibition from the flocculus and ventral paraflocculus in monkeys. 
  • Responses of ventral cochlear nucleus neurons to contralateral sound after conductive hearing loss. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Robustness of a neural network model for differencing. 
  • Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. 
  • Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. 
  • Semantic priming in a cortical network model. 
  • Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition. 
  • Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control. 
  • Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. 
  • Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. 
  • Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. 
  • Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization. 
  • Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. 
  • Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. 
  • Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. 
  • Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Synchronization properties of networks of electrically coupled neurons in the presence of noise and heterogeneities. 
  • Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition. 
  • Temporally distinct mechanisms of use-dependent depression at inhibitory synapses in the rat hippocampus in vitro. 
  • The action of oxygen and oxygen at high pressure on inhibitory transmission. 
  • The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. 
  • The nigrotectal projection in the cat: an electron microscope autoradiographic study. 
  • The role of delayed suppression in slow and fast contrast adaptation in V1 simple cells. 
  • Top-down enhancement and suppression of the magnitude and speed of neural activity. 
  • Tris buffer attenuates acetylcholine responses in Aplysia neurons. 
  • Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. 
  • Two's a crowd: suppressed V4 visual responses to sequential stimuli. 
  • Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. 
  • What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schmehl, Meredith, Student, Neurobiology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering