Synaptic Transmission

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  Subject Areas on Research

  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A comparison of chemical and electrical synaptic transmission between single sensory cells and a motoneurone in the central nervous system of the leech. 
  • A comparison of stapedial reflex fatigue with repetitive stimulation and single-fiber EMG in myasthenia gravis. 
  • A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. 
  • A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. 
  • A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. 
  • A simulation study of information transmission by multi-unit microelectrode recordings. 
  • A study of the rat septohippocampal pathway using anterograde transport of horseradish peroxidase. 
  • A voltammetric and mathematical analysis of histaminergic modulation of serotonin in the mouse hypothalamus. 
  • ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Abnormal neuronal excitability in hippocampal slices from kindled rats. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of synaptic regulation by phosducin in retinal slices. 
  • Accelerated development of rat sympathetic neurotransmission caused by neonatal triiodothyronine administration. 
  • Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition. 
  • Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. 
  • Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. 
  • Activity-dependent modulation of synaptic AMPA receptor accumulation. 
  • Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. 
  • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. 
  • Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke. 
  • Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. 
  • Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. 
  • Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. 
  • Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. 
  • Alzheimer's disease and the glutamate NMDA receptor. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • An electrophysiological analysis of oxygen and pressure on synaptic transmission. 
  • An electrophysiological study of the forebrain projection of nucleus commissuralis: preliminary identification of presumed A2 catecholaminergic neurons. 
  • An immunologically induced defect of neuromuscular transmission in rats and rabbits. 
  • Anaesthetic action of magnesium ions. 
  • Analysis of pairs of individual Ia-E.P.S.P.S in single motoneurones. 
  • Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission. 
  • Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system. 
  • Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. 
  • Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. 
  • Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. 
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. 
  • Astrocytes: Orchestrating synaptic plasticity? 
  • Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches. 
  • Autoimmune disorders of neuromuscular transmission. 
  • Autoimmunity and neurological disease: antibody modulation of synaptic transmission. 
  • Automated analysis of neuromuscular 'jitter'. 
  • Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors. 
  • Baclofen disrupts passive avoidance retention in rats. 
  • Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice. 
  • Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission. 
  • Behavior of identified Edinger-Westphal neurons during ocular accommodation. 
  • Biochemical correlates of transmission mediated by glutamate and aspartate. 
  • Biological functions of activity-dependent transcription revealed. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. 
  • Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression. 
  • Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. 
  • Calcium regulation of neuronal gene expression. 
  • Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. 
  • Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. 
  • Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. 
  • Cell Biology of Astrocyte-Synapse Interactions. 
  • Cellular and Synaptic Properties of Local Inhibitory Circuits. 
  • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. 
  • Cellular physiology of hypoxia of the mammalian central nervous system. 
  • Central acoustic tract in an echolocating bat: an extralemniscal auditory pathway to the thalamus. 
  • Changes in extracellular calcium and magnesium and synaptic transmission in isolated mouse spinal cord. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Changes in synaptic transmission produced by hydrogen peroxide. 
  • Chapter 12 Neurotoxicology of neuromuscular transmission. 
  • Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx. 
  • Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala. 
  • Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. 
  • Circumstances influencing Otto Loewi's discovery of chemical transmission in the nervous system. 
  • Clinical neurophysiology of disorders of the neuromuscular junction. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Cocaine increases stimulated dopamine release more in periadolescent than adult rats. 
  • Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. 
  • Coherence potentials: loss-less, all-or-none network events in the cortex. 
  • Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat. 
  • Common mechanisms underlying refractive error identified in functional analysis of gene lists from genome-wide association study results in 2 European British cohorts. 
  • Common synaptic effects of pentylenetetrazol and penicillin. 
  • Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Computational inference of neural information flow networks. 
  • Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures. 
  • Contributions of neural tone to in vivo passive muscle--tendon unit biomechanical properties in a rat rotator cuff animal model. 
  • Control of the gain of visual-motor transmission occurs in visual coordinates for smooth pursuit eye movements. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Corollary discharge across the animal kingdom. 
  • Correlated firing among major ganglion cell types in primate retina. 
  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 
  • Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. 
  • De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. 
  • Deafening drives cell-type-specific changes to dendritic spines in a sensorimotor nucleus important to learned vocalizations. 
  • Decoding of temporal intervals from cortical ensemble activity. 
  • Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. 
  • Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism. 
  • Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. 
  • Degenerative and regenerative changes in central projections of glossopharyngeal and vagal sensory neurons after peripheral axotomy in cats: a structural basis for central reorganization of arterial chemoreflex pathways. 
  • Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting. 
  • Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: intracellular staining in vivo and in vitro. 
  • Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia. 
  • Depression at thalamocortical synapses: the key for cortical neuronal adaptation? 
  • Depression by calcium of spontaneous transmitter release at the mammalian neuromuscular junction. 
  • Depression of glutamate-mediated synaptic transmission by benzyl alcohol. 
  • Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion. 
  • Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes. 
  • Development of central control of norepinephrine turnover and release in the rat heart: responses to tyramine, 2-deoxyglucose and hydralazine. 
  • Development of dopamine neurotransmission and uptake inhibition in the caudate nucleus as measured by fast-cyclic voltammetry. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Development of sympathetic ganglionic neurotransmission in the neonatal rat. Pre- and postganglionic nerve response to asphyxia and 2-deoxyglucose. 
  • Developmental differences in the sensitivity of hippocampal GABAA receptor-mediated IPSCS to ethanol. 
  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Differential effects of ethanol on memory in adolescent and adult rats. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential expression of glutamate receptors in avian neural pathways for learned vocalization. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. 
  • Diphenylhydantoin reduces the outward current of the action potential in Aplysia. 
  • Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. 
  • Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. 
  • Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. 
  • Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Double-step repetitive stimulation in myasthenia gravis. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. 
  • Eaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Effect of nerve growth factor on synaptic depression after axotomy. 
  • Effects of D-penicillamine on neuromuscular transmission in rats. 
  • Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro. 
  • Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials. 
  • Effects of magnesium and calcium on neurones in the central nervous system. 
  • Effects of micro-iontophoretic administration of magnesium and calcium on neurones in the central nervous system of cats. 
  • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. 
  • Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations. 
  • Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors. 
  • Effects of synaptic noise and filtering on the frequency response of spiking neurons. 
  • Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats. 
  • Effects of transient forebrain ischemia in area CA1 of the gerbil hippocampus: an in vitro study. 
  • Electromyography in disorders of neuromuscular transmission. 
  • Electroneuroprostheses: past and present uses in man. 
  • Electrophysiologic tests of neuromuscular transmission. 
  • Electrophysiological correlates to the intrinsic optical signal in the rat neocortical slice. 
  • Enhancement of transmission at the developing retinogeniculate synapse. 
  • Enhancement of whole cell synaptic currents by low osmolarity and by low [NaCl] in rat hippocampal slices. 
  • Ephaptic transmission in hemifacial spasm: a single-fiber EMG study. 
  • Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures. 
  • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. 
  • Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. 
  • Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. 
  • Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. 
  • Evaluating dopamine reward pathway in ADHD: clinical implications. 
  • Evidence for impaired cortical inhibition in patients with unipolar major depression. 
  • Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation. 
  • Evoked sustained focal potentials and membrane potential of neurons and of unresponsive cells of the spinal cord. 
  • Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. 
  • Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures. 
  • Extracellular calcium and action potentials of soma and dendrites of hippocampal pyramidal cells. 
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. 
  • Facilitatory effects of 4-aminopyridine on neuromuscular transmission in disease states. 
  • Facilitatory effects of 4-aminopyridine on normal neuromuscular transmission. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Finite volume stiffness matrix for solving anisotropic cardiac propagation in 2-D and 3-D unstructured meshes. 
  • Firing frequency of leaky intergrate-and-fire neurons with synaptic current dynamics. 
  • Firing rate of the noisy quadratic integrate-and-fire neuron. 
  • For whom the bird sings: context-dependent gene expression. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus. 
  • Functional development of the cervical sympathetic pathway in the neonatal rat. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Functional neuroimaging of genetic variation in serotonergic neurotransmission. 
  • Further electrophysiological studies of neuromuscular transmission in an animal model of myasthenia gravis. 
  • G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. 
  • GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. 
  • GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus. 
  • GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. 
  • GABAergic neurons of mammalian cerebral cortex: widespread subclass defined by somatostatin content. 
  • GAP-43 as a 'calmodulin sponge' and some implications for calcium signalling in axon terminals. 
  • Gain modulation by nicotine in macaque v1. 
  • Genetic and genomic approaches to reward and addiction. 
  • Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. 
  • Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight. 
  • Glial cells and chronic pain. 
  • Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation. 
  • Glutamine can enhance synaptic transmission in hippocampal slices. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • Heterogeneity of dopamine receptors. 
  • High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats. 
  • High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. 
  • High-voltage stimulation over the human spinal cord: sources of latency variation. 
  • Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients. 
  • Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. 
  • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. 
  • How connectivity, background activity, and synaptic properties shape the cross-correlation between spike trains. 
  • How many channels should there be in a gap junction? 
  • How noise affects the synchronization properties of recurrent networks of inhibitory neurons. 
  • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. 
  • Hyperexcitability following moderate hypoxia in hippocampal tissue slices. 
  • Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices. 
  • Hypoxic failure of synaptic transmission in the isolated spinal cord, and the effects of divalent cations. 
  • Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine. 
  • Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. 
  • Identity of a pathway for saccadic suppression. 
  • Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout. 
  • Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • In vitro modulation of endogenous rhythms by AC electric fields: Syncing with clinical brain stimulation. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function. 
  • Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF. 
  • Independent sources of quantal variability at single glutamatergic synapses. 
  • Information processing in the primate retina: circuitry and coding. 
  • Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. 
  • Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. 
  • Instructive signals for motor learning from visual cortical area MT. 
  • Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. 
  • Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala. 
  • Interaction of anaesthetics with electrical synapses. 
  • Interactions of nigrostriate synaptic transmission, iontophoretic O-methylated phenethylamines, dopamine, apomorphine and acetylcholine. 
  • Intercostal muscle biopsy studies in myasthenia gravis: clinical correlations and the direct effects of drugs and myasthenic serum. 
  • Interfering with inhibition may improve motor function. 
  • Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. 
  • Interstitial potassium concentration, slow depolarization and focal potential responses in the dorsal horn of the rat spinal slice. 
  • Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices. 
  • Intracellular magnesium does not antagonize calcium-dependent acetylcholine secretion. 
  • Intravital imaging of mouse embryos. 
  • Intrinsic connections of macaque striate cortex: afferent and efferent connections of lamina 4C. 
  • Intrinsic connections of macaque striate cortex: axonal projections of cells outside lamina 4C. 
  • Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways. 
  • Kindling: an animal model of complex partial epilepsy. 
  • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. 
  • Lambert-Eaton myasthenic syndrome: the lack of short-term in vitro effects of serum factors on neuromuscular transmission. 
  • Lasting neuron depression induced by high potassium and its prevention by low calcium and NMDA receptor blockade. 
  • Limitations of approximate solutions for computing the extracellular potential of single fibers and bundle equivalents. 
  • Local excitatory circuits in the intermediate gray layer of the superior colliculus. 
  • Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment. 
  • Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. 
  • Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. 
  • Maturation of sympathetic neurotransmission in the efferent pathway to the rat heart: ultrastructural analysis of ganglionic synaptogenesis in euthyroid and hyperthyroid neonates. 
  • Maturation of sympathetic neurotransmission in the rat heart--III. Developmental changes in reserpine inhibition of norepinephrine uptake into isolated synaptic vesicles. 
  • Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles. 
  • Maturation of sympathetic neurotransmission in the rat heart. II. Enhanced development of presynaptic and postsynaptic components of noradrenergic synapses as a result of neonatal hyperthyroidism. 
  • Maturation of sympathetic neurotransmission in the rat heart. V. Development of baroreceptor control of sympathetic tone. 
  • Maturation of sympathetic neurotransmission in the rat heart. VI. The effect of neonatal central catecholaminergic lesions. 
  • Maturation of sympathetic neurotransmission in the rat heart. VII. Suppression of sympathetic responses by dexamethasone. 
  • Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. 
  • Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Models of dopaminergic and serotonergic signaling. 
  • Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. 
  • Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. 
  • Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter. 
  • Morphology of retinogeniculate axons in the macaque. 
  • Motor learning and memory in the vestibulo-ocular reflex: the dark side. 
  • Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus. 
  • Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. 
  • Multifocal electroretinogram in rhodopsin P347L transgenic pigs. 
  • Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Multiple subclasses of Purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex. 
  • NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background. 
  • NGF is essential for hippocampal plasticity and learning. 
  • Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. I. Changes in the responses of brain stem neurons. 
  • Neuroligins provide molecular links between syndromic and nonsyndromic autism. 
  • Neurological disturbances, nigrostriate synapses, and iontophoretic dopamine and apomorphine after haloperidol. 
  • Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways. 
  • Neuromuscular transmission in myopathies. 
  • Neuronal activity-regulated gene transcription in synapse development and cognitive function. 
  • Neuropeptide Y in the recurrent mossy fiber pathway. 
  • Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? 
  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. 
  • Nitric oxide modulates synaptic vesicle docking fusion reactions. 
  • Nitric oxide synthase is an active enzyme in the spiral ganglion cells of the rat cochlea. 
  • Nonintralaminar thalamostriatal projections in the gray squirrel (Sciurus carolinensis) and tree shrew (Tupaia glis). 
  • Noninvasive ankle distraction: relationship between force, magnitude of distraction, and nerve conduction abnormalities. 
  • Nonlinear signal transfer from mouse rods to bipolar cells and implications for visual sensitivity. 
  • Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina. 
  • Novel medication targets for the treatment of alcoholism: preclinical studies. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-1 receptors, and H-1 receptor-mediated stimulation of phospholipid turnover. 
  • Optimal information storage and the distribution of synaptic weights: perceptron versus Purkinje cell. 
  • Organization of the intermediate gray layer of the superior colliculus. I. Intrinsic vertical connections. 
  • Origin of epicardial ST-T wave potentials in the intact dog. 
  • Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. 
  • Oxygen dependency of synaptic transmission at the squid Loligo pealei giant synapse. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • Paradoxical elevation of sympathetic activity during catecholamine infusion in rats. 
  • Pathologic role of nitrergic neurotransmission in mood disorders. 
  • Pathophysiology of neuronal signaling in the cerebral cortex. 
  • Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Peripheral nerve electrical stimulation. 
  • Peripheral target regulation of dendritic geometry in the rat superior cervical ganglion. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Personal-computer-based single-fibre EMG jitter analysis system. 
  • Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. 
  • Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. 
  • Pitfalls and errors in measuring jitter. 
  • Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 
  • Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. 
  • Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release. 
  • Practical Bayesian inference using mixtures of mixtures. 
  • Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. 
  • Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus. 
  • Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses. 
  • Proline-induced inhibition of glutamate release in hippocampal area CA1. 
  • Proline-induced potentiation of glutamate transmission. 
  • Prolonged exposure to high potassium concentration results in irreversible loss of synaptic transmission in hippocampal tissue slices. 
  • Properties of the pathways from the lateral amygdal nucleus to basolateral nucleus and amygdalostriatal transition area. 
  • Protease inhibitors implicate metalloendoprotease in synaptic transmission at the mammalian neuromuscular junction. 
  • Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. 
  • Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. 
  • Quantifying synapses: an immunocytochemistry-based assay to quantify synapse number. 
  • Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. 
  • Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. 
  • Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. 
  • Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo. 
  • Recurrent circuitry dynamically shapes the activation of piriform cortex. 
  • Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Reflex effects and postsynaptic membrane potential changes during epileptiform activity induced by penicillin in decapitate spinal cords. 
  • Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. 
  • Regulation of synaptic connectivity by glia. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. 
  • Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. 
  • Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Reward-motivated learning: mesolimbic activation precedes memory formation. 
  • Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award. 
  • Robustness of a neural network model for differencing. 
  • Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. 
  • Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation. 
  • Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. 
  • STDP in a bistable synapse model based on CaMKII and associated signaling pathways. 
  • Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. 
  • Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling. 
  • Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. 
  • Self-administering cannabinoids. 
  • Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells. 
  • Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. 
  • Short-term effects of prednisolone on neuromuscular transmission in normal rats and those with experimental autoimmune myasthenia gravis. 
  • Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. 
  • Simple spike responses of gaze velocity Purkinje cells in the floccular lobe of the monkey during the onset and offset of pursuit eye movements. 
  • Simultaneous optical recording of evoked and spontaneous transients of membrane potential and intracellular calcium concentration with high spatio-temporal resolution. 
  • Single fiber electromyography in myasthenia gravis during pregnancy. 
  • Single fiber electromyography. 
  • Single-fiber electromyography in myasthenia gravis. 
  • Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. 
  • Spike avalanches exhibit universal dynamics across the sleep-wake cycle. 
  • Spine microdomains for postsynaptic signaling and plasticity. 
  • Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. 
  • Stable propagation of a burst through a one-dimensional homogeneous excitatory chain model of songbird nucleus HVC. 
  • Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. 
  • Suckling behavior of the infant rat: modulation by a developing neurotransmitter system. 
  • Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. 
  • Surgeon's foot: a report of sural nerve palsy. 
  • Sustained evoked potential changes of the spinal cord. 
  • Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. 
  • Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. 
  • Synaptic integration of olfactory information in mouse anterior olfactory nucleus. 
  • Synaptic interactions underlying song-selectivity in the avian nucleus HVC revealed by dual intracellular recordings. 
  • Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synaptic transformations underlying highly selective auditory representations of learned birdsong. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • Synchronization properties of networks of electrically coupled neurons in the presence of noise and heterogeneities. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. 
  • Temporally distinct mechanisms of use-dependent depression at inhibitory synapses in the rat hippocampus in vitro. 
  • Thalamocortical and corticocortical interactions in the somatosensory system. 
  • The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. 
  • The G72/G30 gene complex and cognitive abnormalities in schizophrenia. 
  • The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways. 
  • The action of hydrogen peroxide on paired pulse and long-term potentiation in the hippocampus. 
  • The action of oxygen and oxygen at high pressure on inhibitory transmission. 
  • The clearing of excess potassium from extracellular space in spinal cord and cerebral cortex. 
  • The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. 
  • The effect of changing extracellular potassium concentration on synaptic transmission in isolated spinal cords. 
  • The effect of cholinesterase inhibitors of SFEMG in myasthenia gravis. 
  • The effect of depressing glial function in rat brain in situ on ion homeostasis, synaptic transmission, and neuron survival. 
  • The effect of graded hypertonia on interstitial volume, tissue resistance and synaptic transmission in rat hippocampal tissue slices. 
  • The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. 
  • The effect of stimulus pulse duration on selectivity of neural stimulation. 
  • The effect of xanthine/xanthine oxidase generated reactive oxygen species on synaptic transmission. 
  • The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice. 
  • The effects of moderate changes of extracellular K+ and Ca2+ on synaptic and neural function in the CA1 region of the hippocampal slice. 
  • The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea-pig. 
  • The effects of temperature on synaptic transmission in hippocampal tissue slices. 
  • The electrodiagnosis of myasthenia gravis. 
  • The extent and mechanism of the loss of function caused by strongly hypotonic solutions in rat hippocampal slices. 
  • The genesis of seizures in vitro: axon terminal excitability. 
  • The mechanism of the blockade of synaptic transmission in the mammalian spinal cord by diethyl ether and by thiopental. 
  • The mechanisms underlying the spatial spreading of signaling activity. 
  • The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex. 
  • The neuromuscular blocking effects of therapeutic concentrations of various antibiotics on normal rat skeletal muscle: a quantitative comparison. 
  • The nigrotectal projection in the cat: an electron microscope autoradiographic study. 
  • The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol. 
  • The role of NMDA receptors in in vitro epileptogenesis. 
  • The role of protein phosphatases in synaptic transmission, plasticity and neuronal development. 
  • The role of protein synthesis in striatal long-term depression. 
  • The structure of multi-neuron firing patterns in primate retina. 
  • Therapeutic approaches for shankopathies. 
  • Time course of information about motion direction in visual area MT of macaque monkeys. 
  • Toward a Neurocentric View of Learning. 
  • Trans-synaptic increase in RNA coding for tyrosine hydroxylase in a rat sympathetic ganglion. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Tris buffer attenuates acetylcholine responses in Aplysia neurons. 
  • Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. 
  • Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel. 
  • Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. 
  • Use of intrinsic optical signals to monitor physiological changes in brain tissue slices. 
  • Use of the single electrode voltage clamp to perform noise and relaxation studies of acetylcholine-activated channels in Aplysia neurons. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. 
  • Waiting periods versus early innervation: the development of axonal connections in the zebra finch song system. 
  • What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. 
  • [Problem of neuronal reception and the dopamine hypothesis of schizophrenia]. 
  • gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
• 

  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering