Neuralgia

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  Subject Areas on Research

  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • A PROMIS Measure of Neuropathic Pain Quality. 
  • A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. 
  • A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice. 
  • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. 
  • A prospective study of the herpes zoster severity of illness. 
  • A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. 
  • Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions. 
  • Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. 
  • Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. 
  • Are current therapies useful for the prevention of postherpetic neuralgia? A critical analysis of the literature. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain. 
  • CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. 
  • Causes and prevention of chronic postsurgical pain. 
  • Central Mechanisms Mediating Thrombospondin-4-induced Pain States. 
  • Characterizing chronic pain phenotypes in multiple sclerosis: a nationwide survey study. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy. 
  • Chronic headache resulting from postoperative supraorbital neuralgia. 
  • Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions. 
  • Comparing the Value of Data Visualization Methods for Communicating Harms in Clinical Trials. 
  • Complex salvage procedures for severe lower extremity nerve pain. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Concurrent validity of a low-cost and time-efficient clinical sensory test battery to evaluate somatosensory dysfunction. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Conservative Management of Neuropathic Pain in a Patient With Pancoast-Tobias Syndrome: A Case Report. 
  • Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18. 
  • Dental Students' Learning Experiences and Preferences Regarding Orofacial Pain: A Cross-Sectional Study. 
  • Dental students' perceived level of competence in orofacial pain. 
  • Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause. 
  • Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Diabetic truncal mononeuropathy: electromyographic evaluation. 
  • Different immune cells mediate mechanical pain hypersensitivity in male and female mice. 
  • Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • Dorsal root entry zone lesions for the treatment of post-herpetic neuralgia. 
  • Dorsal root entry zone lesions for the treatment of postherpetic neuralgia. 
  • Dorsal root entry zone lesions in the treatment of pain following brachial plexus avulsion, spinal cord injury and herpes zoster. 
  • Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. 
  • Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain. 
  • Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. 
  • Epigenetics of chronic pain after thoracic surgery. 
  • Evaluating optimized temporal patterns of spinal cord stimulation (SCS). 
  • Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. 
  • Genetic studies of human neuropathic pain conditions: a review. 
  • Harms are assessed inconsistently and reported inadequately Part 2: nonsystematic adverse events. 
  • Harms are assessed inconsistently and reported inadequately part 1: systematic adverse events. 
  • Herpes zoster in older adults. 
  • Herpes zoster in the elderly: issues related to geriatrics. 
  • Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. 
  • Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer. 
  • How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study. 
  • Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. 
  • Inflammation and Infection in Pain and the Role of GPR37. 
  • Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. 
  • Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol. 
  • Integrative and behavioral approaches to the treatment of cancer-related neuropathic pain. 
  • Intercostal neuralgia of pregnancy. 
  • Intraoperative pelvic brachytherapy for treatment of locally advanced or recurrent colorectal cancer. 
  • Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. 
  • Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion. 
  • Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury? 
  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. 
  • L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAP on ipsilateral dorsal horn. 
  • Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain. 
  • Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. 
  • Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence. 
  • Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice. 
  • Matrix metalloprotease regulation of neuropathic pain. 
  • Mechanisms and models of spinal cord stimulation for the treatment of neuropathic pain. 
  • Mechanistic contribution of CaV3.2 calcium channels to trigeminal neuralgia pathophysiology not clarified. 
  • Medical screening for red flags in the diagnosis and management of musculoskeletal spine pain. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. 
  • Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats. 
  • Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation. 
  • Multicolumn spinal cord stimulation for predominant back pain in failed back surgery syndrome patients: a multicenter randomized controlled trial. 
  • Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis. 
  • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. 
  • Neuropathic Ocular Pain due to Dry Eye is Associated with Multiple Comorbid Chronic Pain Syndromes. 
  • Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. 
  • Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. 
  • Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. 
  • Opportunities for selective reporting of harms in randomized clinical trials: Selection criteria for non-systematic adverse events. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • Pain and Physical Functioning in Neuropathic Pain: A Systematic Review of Psychometric Properties of Various Outcome Measures. 
  • Pain experiences among those living with hidradenitis suppurativa: a qualitative study. 
  • Peripheral nerve vein wrapping for intractable lower extremity pain. 
  • Persistent postoperative pain: mechanisms and modulators. 
  • Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. 
  • Post-Thoracotomy Pain: Current Strategies for Prevention and Treatment. 
  • Postherpetic neuralgia in immunocompetent elderly people. 
  • Prevention of chronic pain after surgical nerve injury: amputation and thoracotomy. 
  • Quantitative sensory testing in predicting persistent pain after joint replacement surgery: promise and challenges. 
  • Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. 
  • Recurrent Henoch-Schönlein Purpura with bullous rash and pulmonary nodules. 
  • Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. 
  • Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Restoring invisible and abandoned trials of gabapentin for neuropathic pain: a clinical and methodological investigation. 
  • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. 
  • Roundtable on postherpetic neuralgia--what, why, how long, and what's next? 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • Salvage C2 ganglionectomy after C2 nerve root decompression provides similar pain relief as a single surgical procedure for intractable occipital neuralgia. 
  • Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. 
  • Simple Neurectomy Versus Neurectomy With Intramuscular Implantation for Interdigital Neuroma: A Comparative Study. 
  • Spinal cavernous and capillary hemangiomas in adults. 
  • Spinal cord stimulation for intercostal neuralgia in a patient with implantable cardiac defibrillator and biventricular pacing. 
  • Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord. 
  • Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control. 
  • Surgical treatment of chronic lower extremity neuropathic pain. 
  • Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement. 
  • Survey of neuromuscular injuries to the patient and surgeon during urologic laparoscopic surgery. 
  • T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice. 
  • TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. 
  • TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. 
  • TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. 
  • Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. 
  • The Neurostimulation Appropriateness Consensus Committee (NACC) Recommendations for Infection Prevention and Management. 
  • The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain. 
  • The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. 
  • The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. 
  • The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. 
  • Therapy for chemotherapy-induced peripheral neuropathy--in reply. 
  • Thoraconeuralgia gravidarum. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. 
  • Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain. 
  • Treatment and prevention of postherpetic neuralgia. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Treatment considerations for patients with neuropathic pain and other medical comorbidities. 
  • Ultrasound-Guided Microwave Ablation for the Management of Inguinal Neuralgia: A Preliminary Study with 1-Year Follow-up. 
  • Ultrasound-guided microwave ablation in the treatment of inguinal neuralgia. 
  • Ultrasound-guided peripheral nerve stimulator placement in two soldiers with acute battlefield neuropathic pain. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Utilization of spinal cord stimulation in patients with failed back surgery syndrome. 
  • [Analgesic effect of intrathecal injection of Herpes simplex virus type I amplicon vector-mediated human preproenkephalin gene on chronic neuropathic pain: experiment with rats]. 
  • miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
  • p38 MAPK, microglial signaling, and neuropathic pain. 
  • β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.