Neuroglia

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  Subject Areas on Research

  • A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia. 
  • A Tribute to Ben Barres: Remembrances from Barres Lab Members. 
  • A new model of the blood--brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions. 
  • A tridomain model for potassium clearance in optic nerve of Necturus. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Abnormal production of interleukin-1 by microglia from trisomy 16 mice. 
  • Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures. 
  • Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • An endogenous source of the superoxide anion in the central nervous system. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. 
  • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. 
  • Apolipoprotein E protects against NMDA excitotoxicity. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Apolipoprotein E suppresses glial cell secretion of TNF alpha. 
  • Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. 
  • Apolipoprotein-E allele-specific regulation of nitric oxide production. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • Astrocytes in chronic pain and itch. 
  • Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study. 
  • Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. 
  • Biological activity of interleukin-10 in the central nervous system. 
  • Brain tumors in man and animals: report of a workshop. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • C. elegans as a model to study glial development. 
  • Causes and prevention of chronic postsurgical pain. 
  • Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions. 
  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. 
  • Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events? 
  • Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster. 
  • Characterization of interleukin-1 production by microglia in culture. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Chemotaxis by a CNS macrophage, the microglia. 
  • Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. 
  • Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. 
  • Control of neural development and function by glial neuroligins. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. 
  • Depression of sustained evoked potentials and glial depolarization in the spinal cord by barbiturates and by diphenylhydantoin. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. 
  • Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. 
  • Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood. 
  • Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. 
  • Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. 
  • Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. 
  • Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence? 
  • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion. 
  • E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. 
  • Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. 
  • Effect of glutamate analogues on brain tumor cell lines. 
  • Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. 
  • Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy. 
  • Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions. 
  • Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. 
  • Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. 
  • Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. 
  • Enhanced production of superoxide anion by microglia from trisomy 16 mice. 
  • Enriching neural stem cell and anti-inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats. 
  • Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay. 
  • Evidence for brain glial activation in chronic pain patients. 
  • Expanding gliogenesis. 
  • Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. 
  • Expression of statin, a non-proliferation-dependent nuclear protein, in the postnatal rat brain: evidence for substantial retention of neuroglial proliferative capacity with aging. 
  • Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain. 
  • Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • Genetic approaches to access cell types in mammalian nervous systems. 
  • Glia and pain: is chronic pain a gliopathy? 
  • Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression. 
  • Glial ankyrins facilitate paranodal axoglial junction assembly. 
  • Glial cells and chronic pain. 
  • Glial localization of antiquitin: implications for pyridoxine-dependent epilepsy. 
  • Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro-oncogenesis in rats. 
  • Host response to microgel coatings on neural electrodes implanted in the brain. 
  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. 
  • Immunolocalization of laminin in neoplasms of the central and peripheral nervous systems. 
  • In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS. 
  • Increased expression of p130 in Alzheimer disease. 
  • Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. 
  • Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions. 
  • Lactose supports Muller cell protein expression patterns in the absence of the retinal pigment epithelium. 
  • Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport. 
  • Local gene regulation in radial glia: Lessons from across the nervous system. 
  • Long-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes. 
  • Look who is weaving the neural web: glial control of synapse formation. 
  • Malignant supratentorial glial-neuronal neoplasms: report of two cases and review of the literature. 
  • Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. 
  • Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. 
  • Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. 
  • Microglia, an in vivo source of reactive oxygen species in the brain. 
  • Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones. 
  • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. 
  • Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor. 
  • Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. 
  • Morphological diversity of single neurons in molecularly defined cell types. 
  • Morphological features of the entorhinal-hippocampal connection. 
  • NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism. 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • Nanoscale laminin coating modulates cortical scarring response around implanted silicon microelectrode arrays. 
  • Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. 
  • Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. 
  • Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. 
  • Neuroinflammation after surgery: from mechanisms to therapeutic targets. 
  • Neuron/glia relationships observed over intervals of several months in living mice. 
  • Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. 
  • Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons. 
  • New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. 
  • Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. 
  • PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia. 
  • Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. 
  • Pleiotropic function of TRPV4 ion channels in the central nervous system. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Production of superoxide anions by a CNS macrophage, the microglia. 
  • Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity. 
  • Prolonged dark adaptation changes connexin expression in the mouse retina. 
  • Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 
  • Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. 
  • Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. 
  • Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. 
  • Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. 
  • Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 
  • Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. 
  • Regulation of cerebral glucose metabolism. 
  • Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism. 
  • Regulation of microglial function by interferons. 
  • Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans. 
  • Regulation of synaptic connectivity by glia. 
  • Removal of optic disc stalks during diabetic vitrectomy. 
  • Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord. 
  • Response of brain tissue to chronically implanted neural electrodes. 
  • Retinal glioneuronal hamartoma in neurofibromatosis type 1. 
  • Retinal vasoproliferative tumors: surgical management and histological findings. 
  • Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. 
  • Robo functions as an attractive cue for glial migration through SYG-1/Neph. 
  • Seizure-like spreading depression in immature rabbit hippocampus in vitro. 
  • Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. 
  • Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains. 
  • Sex, glia, and development: interactions in health and disease. 
  • Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood. 
  • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. 
  • So-called massive retinal gliosis: A critical review and reappraisal. 
  • Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires. 
  • Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. 
  • Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. 
  • Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation. 
  • Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors. 
  • Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation. 
  • TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. 
  • TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. 
  • Targeted disruption of Müller cell metabolism induces photoreceptor dysmorphogenesis. 
  • The development of excitatory synapses in cultured spinal neurons. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The impact of chronic blood-brain barrier breach on intracortical electrode function. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The interplay between neurons and glia in synapse development and plasticity. 
  • Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. 
  • Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy. 
  • Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments. 
  • Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression. 
  • [Effects of intravenous anesthetics on LPS-induced production of tumour necrosis factor-alpha from primary cultures of rat glial cells in vitro]. 
  • [Identification and evaluation of properties of benzodiazepine receptors of glial and neuronal fractions of human cerebral cortex]. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bilbo, Staci D., Professor of Psychology and Neuroscience, Psychology & Neuroscience
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering