Neuronal Ceroid-Lipofuscinoses

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  Subject Areas on Research

  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • Drug-induced dystonia in neuronal ceroid-lipofuscinosis. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis. 
  • Neuronal ceroid lipofuscinosis diagnosed via skin biopsy. 
  • Neuronal ceroid lipofuscinosis: a common pathway? 
  • The CLN3 gene is a novel molecular target for cancer drug discovery.