Neurons, Afferent

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  Subject Areas on Research

  • A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. 
  • A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. 
  • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A spinal GABAergic mechanism is necessary for bladder inhibition by pudendal afferent stimulation. 
  • Activation and inhibition of the micturition reflex by penile afferents in the cat. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Active tactile exploration influences the functional maturation of the somatosensory system. 
  • Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes. 
  • Analysis of pairs of individual Ia-E.P.S.P.S in single motoneurones. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Baroreceptor afferents modulate brain excitation and influence susceptibility to toxic effects of hyperbaric oxygen. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Changes in spontaneous activity and CNS morphology associated with conductive and sensorineural hearing loss in chickens. 
  • Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level. 
  • Converting neural signals from place codes to rate codes. 
  • Corollary discharge across the animal kingdom. 
  • Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex. 
  • Direct and relayed projection of periodontal receptor afferents to the cerebellum in the ferret. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces. 
  • Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level. 
  • Dynamics of the sensory response to urethral flow over multiple time scales in rat. 
  • Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. 
  • Effect of blood pressure on A2 noradrenergic neurons. 
  • Effect of selective diaphragmatic paralysis on the inspiratory motor drive. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Electrophysiological evidence for afferent nerve fibers in human ventral roots. 
  • Encoding of tactile stimulus location by somatosensory thalamocortical ensembles. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Excitation properties of computational models of unmyelinated peripheral axons. 
  • Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence. 
  • Exteroceptive suppression periods and pericranial muscle tenderness in chronic tension-type headache: Effects of psychopathology, chronicity, and disability 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular potassium activity, intracellular and extracellular potential responses in the spinal cord. 
  • Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve. 
  • Fiber sorting in the fasciculus gracilis of squirrel monkeys. 
  • Focal synaptic potentials due to discrete mossy-fibre arrival volleys in the cerebellar cortex. 
  • Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus. 
  • Functional expression of Mammalian odorant receptors. 
  • Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures. 
  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 
  • Hebb's dream: the resurgence of cell assemblies. 
  • How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • How is a sensory map read Out? Effects of microstimulation in visual area MT on saccades and smooth pursuit eye movements. 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. 
  • Intravesical capsaicin therapy: a review. 
  • Isolated deficiency of vitamin E with progressive neurologic deterioration. 
  • LPS-sensory peptide communication in experimental cystitis. 
  • Lumbar plexus and sciatic nerve block for knee arthroplasty: comparison of ropivacaine and bupivacaine. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons. 
  • Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. 
  • Model of global spontaneous activity and local structured activity during delay periods in the cerebral cortex. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices. 
  • Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. 
  • Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. 
  • Neonatal whisker removal reduces the discrimination of tactile stimuli by thalamic ensembles in adult rats. 
  • Network level properties of short-term plasticity in the somatosensory system. 
  • Neurogenic inflammation and pancreatitis. 
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. 
  • Neuronal nicotinic acetylcholine receptors in rat trigeminal ganglia. 
  • Neurophysiology: neural fingerprints of visual attention. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • Olfactory marker protein mRNA is found in axons of olfactory receptor neurons. 
  • Olfactory recognition and discrimination in Caenorhabditis elegans. 
  • Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs. 
  • Organization of the superior olivary complex in the guinea pig: II. Patterns of projection from the periolivary nuclei to the inferior colliculus. 
  • Parallels in the visual afferent projections of the thalamus in the hedgehog (Paraechinus hypomelas) and the turtle (Pseudemys scripta). 
  • Patterns of innervation of outer hair cells in a chimpanzee: I. Afferent and reciprocal synapses. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. 
  • Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. 
  • Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica. 
  • Psychophysiological interactions between caffeine and nicotine. 
  • Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. 
  • Rapid remodeling of sensory endings in the corneas of living mice. 
  • Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. 
  • Regulation of axon guidance and extension by three-dimensional constraints. 
  • Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Responses of cultured rat trigeminal ganglion neurons to bitter tastants. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Role of pudendal afferents in voiding efficiency in the rat 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Sensitizing effects of leukotriene B4 on intradental primary afferents. 
  • Sensorimotor encoding by synchronous neural ensemble activity at multiple levels of the somatosensory system. 
  • Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. 
  • Sensory, motor, and combined contexts for context-specific adaptation of saccade gain in humans. 
  • Serotonergic modulation of bladder afferent pathways. 
  • Spasticity: actions of selectivity activated group II muscle spindle afferents on extensor motoneurons. 
  • Specific connections between nerve cells. 
  • Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. 
  • Subdivisions of the medial geniculate body in the tree shrew (Tupaia glis). 
  • Suppression of presynaptic calcium currents by hypoxia in hippocampal tissue slices. 
  • Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex. 
  • Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice. 
  • Synaptic interactions underlying song-selectivity in the avian nucleus HVC revealed by dual intracellular recordings. 
  • Synaptic transformations underlying highly selective auditory representations of learned birdsong. 
  • TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. 
  • TRPA1 is a major oxidant sensor in murine airway sensory neurons. 
  • TRPV1 receptors mediate particulate matter-induced apoptosis. 
  • The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons. 
  • The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons. 
  • The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. 
  • The organization of submodality-specific touch afferent inputs in the vibrissa column. 
  • The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. 
  • Topographic and directional organization of visual motion inputs for the initiation of horizontal and vertical smooth-pursuit eye movements in monkeys. 
  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. 
  • Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter. 
  • Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. 
  • Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • Variation, signal, and noise in cerebellar sensory-motor processing for smooth-pursuit eye movements. 
  • Vestibular signals carried by pathways subserving plasticity of the vestibulo-ocular reflex in monkeys. 
  • Visual cortical signals supporting smooth pursuit eye movements. 
  • Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus. 
  • beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. 
  • cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
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  Keywords of People

  • Clendaniel, Richard Alan, Assistant Professor in Orthopaedic Surgery, Head and Neck Surgery & Communication Sciences
  • De Caceres Bustos, Anabel, Research Scientist, Senior, Anesthesiology
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Professor in Neuroscience, Neurobiology