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Subject Areas on Research
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A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.
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A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.
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A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
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A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae.
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A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.
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A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC.
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A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.
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A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.
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A switch in the control of growth of the wing imaginal disks of Manduca sexta.
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Abl family kinases regulate endothelial barrier function in vitro and in mice.
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Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
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Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.
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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
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Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism.
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Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines.
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Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
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Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory.
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Are Neuropeptide-Reactive T Cells behind Narcolepsy?
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Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
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Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain.
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Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
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Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function.
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Bombyxin is a growth factor for wing imaginal disks in Lepidoptera.
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Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides.
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Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy.
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Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites.
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Calcium-myristoyl switches turn on new lights.
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Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface.
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Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases
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Cellular functions of metallo-endoproteinases.
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Central peptidergic control of gastric acid secretion.
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Chemical messengers of the gut.
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Cholecystokinin.
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Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.
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Comparison of responses to pituitary adenylate cyclase activating peptides 38 and 27 in the pulmonary vascular bed of the cat.
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Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.
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Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow.
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Control of antiviral innate immune response by protein geranylgeranylation.
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Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
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Crustacean peptide and peptide-like pheromones and kairomones.
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Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry.
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Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat.
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Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment.
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Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
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Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.
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Drebrin regulates angiotensin II-induced aortic remodelling.
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Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.
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Drosophila egg-laying site selection as a system to study simple decision-making processes.
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Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.
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Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
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Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
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Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions.
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Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence.
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FBW2 targets GCMa to the ubiquitin-proteasome degradation system.
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Function of tau protein in adult newborn neurons.
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GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
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Gene expression profiling and genetic markers in glioblastoma survival.
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Gonadotropin-releasing hormone neuronal cell lines.
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Histochemical localization of the PBAN receptor in the pheromone gland of Heliothis peltigera.
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Histone deacetylase 3 binds to and regulates the GCMa transcription factor.
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Homer: a protein that selectively binds metabotropic glutamate receptors.
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Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
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Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
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Immortalized hypothalamic gonadotropin-releasing hormone neurons.
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Immunoreactivity to calcitonin gene-related peptide in the superior olivary complex and cochlea of cat and rat.
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Increased expression of galanin in the rat superior cervical ganglion after pre- and postganglionic nerve lesions.
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Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
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Kv3.1b is a novel component of CNS nodes.
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LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.
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Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.
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Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides.
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Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment.
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Mining copper transport genes.
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Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.
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Monitoring neural activity with bioluminescence during natural behavior.
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Morphogenesis and Compartmentalization of the Intestinal Crypt.
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
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NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding.
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Neural and hormonal regulation of pancreatic secretion.
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Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy.
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Neuropeptides and neurotransmitters in Alzheimer's disease: focus on corticotrophin releasing factor.
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Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala.
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Neuropeptides modulate rat chorda tympani responses.
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Neuropeptidomic Analysis of a Genetically Defined Cell Type in Mouse Brain and Pituitary.
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Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.
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New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor.
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PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
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Pediatric narcolepsy.
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Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.
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Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.
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Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells.
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Postprandial neurohormonal control of gastric emptying.
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ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.
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Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica.
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Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
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Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.
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Rat amylin: cloning and tissue-specific expression in pancreatic islets.
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Recent advances in pancreatic endocrine and exocrine secretion.
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Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease.
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Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
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Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons.
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Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
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Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice.
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Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity.
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Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin.
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Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
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Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.
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Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1.
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Testis ecdysiotropin, an insect gonadotropin that induces synthesis of ecdysteroid.
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The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.
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The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.
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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.
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The brain hypocretins and their receptors: mediators of allostatic arousal.
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The control of growth and differentiation of the wing imaginal disks of Manduca sexta.
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The human olfactory transcriptome.
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The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes.
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The membrane skeleton of human erythrocytes and its implications for more complex cells.
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The now and then of gut-brain signaling.
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The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.
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The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis.
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Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
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Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
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Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
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Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.
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Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
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Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.
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dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Jordt, Sven Eric,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
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Tsalik, Ephraim,
Adjunct Associate Professor in the Department of Medicine,
Medicine, Infectious Diseases