Neuropeptides

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  Subject Areas on Research

  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A switch in the control of growth of the wing imaginal disks of Manduca sexta. 
  • APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. 
  • Abl family kinases regulate endothelial barrier function in vitro and in mice. 
  • Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. 
  • Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. 
  • Afferent control of horizontal cell morphology revealed by genetic respecification of rods and cones. 
  • Age-related decline in BubR1 impairs adult hippocampal neurogenesis. 
  • Alterations in receptors for sensory neuropeptides in human inflammatory bowel disease. 
  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Are Neuropeptide-Reactive T Cells behind Narcolepsy? 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. 
  • Augmentation of dopaminergic agents for major depressive disorder. 
  • Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. 
  • Bombyxin is a growth factor for wing imaginal disks in Lepidoptera. 
  • Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. 
  • Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy. 
  • Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites. 
  • Calcium-myristoyl switches turn on new lights. 
  • Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases. 
  • Cellular functions of metallo-endoproteinases. 
  • Central peptidergic control of gastric acid secretion. 
  • Chemical messengers of the gut. 
  • Cholecystokinin. 
  • Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. 
  • Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice. 
  • Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. 
  • Comparison of responses to pituitary adenylate cyclase activating peptides 38 and 27 in the pulmonary vascular bed of the cat. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Conditions associated with ER dysfunction activate homer 1a expression. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Control of antiviral innate immune response by protein geranylgeranylation. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Cross-talk and sensitization of bladder afferent nerves. 
  • Crustacean peptide and peptide-like pheromones and kairomones. 
  • Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry. 
  • Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat. 
  • Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. 
  • Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation. 
  • Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Dopamine transporters and neuronal injury. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction. 
  • Drosophila egg-laying site selection as a system to study simple decision-making processes. 
  • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. 
  • Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions. 
  • Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Function of tau protein in adult newborn neurons. 
  • GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • Gastric inhibitory polypeptide (GIP) binding sites in rat brain. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Gonadotropin-releasing hormone neuronal cell lines. 
  • Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells. 
  • Histochemical localization of the PBAN receptor in the pheromone gland of Heliothis peltigera. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Homer: a protein that selectively binds metabotropic glutamate receptors. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. 
  • Immortalized hypothalamic gonadotropin-releasing hormone neurons. 
  • Immunoreactivity to calcitonin gene-related peptide in the superior olivary complex and cochlea of cat and rat. 
  • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. 
  • Increased expression of galanin in the rat superior cervical ganglion after pre- and postganglionic nerve lesions. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Kv3.1b is a novel component of CNS nodes. 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Mining copper transport genes. 
  • Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death. 
  • Monitoring neural activity with bioluminescence during natural behavior. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. 
  • NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. 
  • Neural and hormonal regulation of pancreatic secretion. 
  • Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy. 
  • Neuropeptides and neurotransmitters in Alzheimer's disease: focus on corticotrophin releasing factor. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Neuropeptides modulate rat chorda tympani responses. 
  • Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. 
  • Null mutant mouse models of somatostatin and cortistatin, and their receptors. 
  • Ontogeny of the striatal neurons expressing the D1 dopamine receptor in humans. 
  • PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. 
  • Pediatric narcolepsy. 
  • Peptide and amine modulation of the Limulus heart: a simple neural network and its target tissue. 
  • Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells. 
  • Plasma membrane monoamine transporters: structure, regulation and function. 
  • Postprandial neurohormonal control of gastric emptying. 
  • ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. 
  • Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica. 
  • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Rat amylin: cloning and tissue-specific expression in pancreatic islets. 
  • Recent advances in pancreatic endocrine and exocrine secretion. 
  • Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. 
  • Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. 
  • Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. 
  • Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. 
  • Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. 
  • TSC2: filling the GAP in the mTOR signaling pathway. 
  • Testis ecdysiotropin, an insect gonadotropin that induces synthesis of ecdysteroid. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. 
  • The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. 
  • The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis. 
  • The control of growth and differentiation of the wing imaginal disks of Manduca sexta. 
  • The human olfactory transcriptome. 
  • The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. 
  • The membrane skeleton of human erythrocytes and its implications for more complex cells. 
  • The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. 
  • The neuropeptide proctolin acts directly on Limulus cardiac muscle to increase the amplitude of contraction. 
  • The now and then of gut-brain signaling. 
  • The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. 
  • The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. 
  • Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. 
  • Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse. 
  • Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. 
  • Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. 
  • Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. 
  • Vasopressin metabolite neuropeptide facilitates simultaneous temporal processing. 
  • Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. 
  • Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. 
  • dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Moorman, Patricia Gripka, Professor in Family Medicine and Community Health, Duke Cancer Institute
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology