Neurotoxins

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  Subject Areas on Research

  • 3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy. 
  • 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells. 
  • Activated human microglia produce the excitotoxin quinolinic acid. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. 
  • Alterations in the neutral proteinase activities of central and peripheral nervous systems of acrylamide-, carbon disulfide-, or 2,5-hexanedione-treated rats. 
  • Alterations of excitatory amino acid receptors in the brain of manganese-treated mice. 
  • Analysis of the afferent limb of the vesicovascular reflex using neurotoxins, resiniferatoxin and capsaicin. 
  • Apolipoprotein E protects against NMDA excitotoxicity. 
  • Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. 
  • Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. 
  • Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins. 
  • Botulinum toxin treatment of social anxiety disorder with hyperhidrosis: a placebo-controlled double-blind trial. 
  • Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. 
  • Calcium and calmodulin stimulated in vitro phosphorylation of rooster brain tubulin and MAP-2 following a single oral dose of tri-o-cresyl phosphate. 
  • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. 
  • Chapter 12 Neurotoxicology of neuromuscular transmission. 
  • Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. 
  • Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. 
  • Delayed neurotoxicity of phenylphosphonothioate esters. 
  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. 
  • Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. 
  • Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. 
  • Developmental neurotoxicity of succeeding generations of insecticides. 
  • Differential alteration of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). 
  • Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. 
  • Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Early differential elevation and persistence of phosphorylated cAMP-response element binding protein (p-CREB) in the central nervous system of hens treated with diisopropyl phosphorofluoridate, an OPIDN-causing compound. 
  • Early differential induction of C-jun in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). 
  • Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats. 
  • Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain? 
  • Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy. 
  • Evidence for p53-mediated modulation of neuronal viability. 
  • Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. 
  • Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. 
  • Gene-environment interactions: neurodegeneration in non-mammals and mammals. 
  • Genetic aspects of behavioral neurotoxicology. 
  • High-performance liquid chromatographic analysis on radial compression column of the neurotoxic tri-o-cresyl phosphate and metabolites. 
  • High-pressure liquid chromatography of neurotoxic phenylphosphonothioate esters and related compounds. 
  • IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD. 
  • Impairments in timing, temporal memory, and reversal learning linked to neurotoxic regimens of methamphetamine intoxication. 
  • In vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins is increased by glycidamide administration. 
  • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation. 
  • Involvement of cytoskeletal proteins in the mechanisms of organophosphorus ester-induced delayed neurotoxicity. 
  • Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? 
  • Kainic acid: neurophysiological and neurotoxic actions. 
  • Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery. 
  • Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats. 
  • Lipid diversity among botulinum neurotoxin-producing clostridia. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Modulation of avian muscarinic cholinergic high affinity binding sites by a neurotoxic organophosphate. 
  • Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. 
  • Molecular conformation of erabutoxin b; atomic coordinates at 2.5 A resolution. 
  • Morphometric analysis for early detection of changes in cellular structure in a toxicological experiment. 
  • Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. 
  • Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. 
  • Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum. 
  • Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. 
  • Neuroprotective and neurodestructive effects of nitric oxide and redox congeners. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. 
  • Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. 
  • Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Persisting behavioral consequences of prenatal domoic acid exposure in rats. 
  • Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol. 
  • Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy. 
  • Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. 
  • Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 
  • Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. 
  • Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism. 
  • Regulation of complex I by Engrailed is complex too. 
  • Requirement for superoxide in excitotoxic cell death. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. 
  • The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. 
  • The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse. 
  • The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. 
  • The neurotoxin quinolinic acid is increased in spinal cords of mice with herpes simplex virus encephalitis. 
  • The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. 
  • The sensorimotor striatum is necessary for serial order learning. 
  • The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. 
  • The use of zebrafish (Danio rerio) as a model system in neurobehavioral toxicology. 
  • Toward an implantable functional electrical stimulation device to correct strabismus. 
  • Toxicity of L-proline toward rat hippocampal neurons. 
  • Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. 
  • Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. 
  • Triphenyl phosphite neurotoxicity in the hen: inhibition of neurotoxic esterase and of prophylaxis by phenylmethylsulfonyl fluoride. 
  • Trophic control of the ornithine decarboxylase/polyamine system in neonatal rat brain regions: lesions caused by 6-hydroxydopamine produce effects selective for cerebellum. 
  • Use of excitatory amino acids to make axon-sparing lesions of hypothalamus. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • Ventral cochlear nucleus responses to contralateral sound are mediated by commissural and olivocochlear pathways. 
  • Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult. 
  • Zebrafish as a neurotoxicological model. 
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  Keywords of People

  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology