Nitric Oxide

• 

  Subject Areas on Research

  • (S)NO signals: translocation, regulation, and a consensus motif. 
  • 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model. 
  • A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. 
  • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. 
  • A genetic analysis of nitrosative stress. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. 
  • A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. 
  • A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. 
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. 
  • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. 
  • A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway. 
  • A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. 
  • A protein microarray-based analysis of S-nitrosylation. 
  • A role for the thromboxane receptor in L-NAME hypertension. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus. 
  • Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. 
  • Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Acute reductions in haematocrit increase flow-mediated dilatation independent of resting nitric oxide bioavailability in humans. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. 
  • Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin. 
  • Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens. 
  • Antioxidant therapy for atherosclerotic vascular disease: the promise and the pitfalls. 
  • Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Apolipoprotein-E allele-specific regulation of nitric oxide production. 
  • Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Ascaris suum, an intestinal parasite, produces morphine. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Assessment of ischemia and reperfusion injury. 
  • Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers. 
  • Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. 
  • Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. 
  • Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. 
  • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. 
  • Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. 
  • Biaxial strain effects on cells from the inner and outer regions of the meniscus. 
  • Bicarbonate-dependent superoxide release and pulmonary artery tone. 
  • Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. 
  • Biochemistry of soluble guanylate cyclase. 
  • Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets. 
  • Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy. 
  • Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. 
  • Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. 
  • Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria. 
  • Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. 
  • C-nitroso donors of nitric oxide. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L. 
  • Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells. 
  • Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Cardioprotective role of S-nitrosylated hemoglobin from rbc. 
  • Cellular and physiological effects of arginine. 
  • Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation. 
  • Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. 
  • Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. 
  • Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway. 
  • Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. 
  • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. 
  • Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. 
  • Commentaries on Viewpoint: Anemia contributes to cardiovascular disease through reductions in nitric oxide. 
  • Compartmentalized nitrosation and nitration in mitochondria. 
  • Concerted nitric oxide/oxygen delivery by hemoglobin. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 
  • Consumption of biogenic nitric oxide in hydrated soil. 
  • Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. 
  • Controlled release of anti-inflammatory agent alpha-MSH from neural implants. 
  • Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin. 
  • Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. 
  • Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. 
  • Current Controversies in Caring for the Critically Ill Pulmonary Embolism Patient. 
  • Cyclic loading alters biomechanical properties and secretion of PGE2 and NO from tendon explants. 
  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. 
  • Cyclosporine increases hepatocyte synthesis of the immunosuppressive free radical nitric oxide. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity. 
  • Cytokinins can act as suppressors of nitric oxide in Arabidopsis. 
  • Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness 
  • Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. 
  • Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. 
  • Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. 
  • Design, synthesis and evaluation of ¹⁵ N- and ¹³ C-labeled molecular probes as hyperpolarized nitric oxide sensors. 
  • Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. 
  • Detection of protein S-nitrosylation with the biotin-switch technique. 
  • Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults. 
  • Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro. 
  • Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training. 
  • Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells. 
  • Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells. 
  • Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. 
  • Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model. 
  • Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. 
  • Discovery of the aquaporins and development of the field. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Dual action antimicrobials: nitric oxide release from quaternary ammonium-functionalized silica nanoparticles. 
  • Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1. 
  • Effect of a nitric oxide donor on microcirculation of acutely denervated skeletal muscle during reperfusion. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of denervation on endothelium-derived relaxing factor-dependent relaxation in the rat cremaster muscle. 
  • Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. 
  • Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis. 
  • Effect of lipopolysaccharide administration on the number, phenotype and content of nuclear molecules in blood microparticles of normal human subjects. 
  • Effects of S-nitroso- N-acetylcysteine on contractile function of reperfused skeletal muscle. 
  • Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children. 
  • Effects of arginase isoforms on NO Production by nNOS. 
  • Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery. 
  • Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. 
  • Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. 
  • Effects of nitric oxide after cardiac transplantation in the setting of recipient pulmonary hypertension. 
  • Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m). 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia. 
  • Efficacy of Nitric Oxide Administration During Neonatal Cardiopulmonary Bypass. 
  • Electrochemical activation of electrodes for amperometric detection of nitric oxide. 
  • Electrochemical detection of nitric oxide in biological fluids. 
  • Electrochemical detection of physiological nitric oxide: materials and methods. 
  • Electrode materials for nitric oxide detection. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Emissions of nitric oxide from 79 plant species in response to simulated nitrogen deposition. 
  • Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. 
  • Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide. 
  • Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. 
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. 
  • Enhancement of gemcitabine cytotoxicity in pancreatic adenocarcinoma through controlled release of nitric oxide. 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. 
  • Epithelial invasion by Escherichia coli bearing Dr fimbriae is controlled by nitric oxide-regulated expression of CD55. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. 
  • Ethanol induced changes in superoxide anion and nitric oxide in cultured microglia. 
  • Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis. 
  • Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. 
  • Exhaled nitric oxide (NO), NO synthase activity, and regulation of nuclear factor (NF)-kappaB. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction. 
  • Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. 
  • Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin. 
  • Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. 
  • Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. 
  • Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators. 
  • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Genetic polymorphisms associated with priapism in sickle cell disease. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. 
  • Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. 
  • HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction. 
  • Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. 
  • Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension. 
  • Hemoglobin and nitric oxide. 
  • Hemoglobin and nitric oxide. 
  • Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. 
  • Hepatic haemodynamic changes following inhibition of endothelium-derived relaxing and hyperpolarising factors in anaesthetised miniature pigs. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. 
  • Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. 
  • How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm. 
  • How do red blood cells dilate blood vessels? 
  • Human Vascular Microphysiological System for in vitro Drug Screening. 
  • Hurricane-loaded soil: effects on nitric oxide emissions from soil. 
  • Hyperbaric oxygen reduces cerebral blood flow by inactivating nitric oxide. 
  • Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury. 
  • Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung. 
  • Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. 
  • Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity. 
  • In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency. 
  • In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. 
  • Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. 
  • Increased in vivo glucose recovery via nitric oxide release. 
  • Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. 
  • Increased nitric oxide production and protection from malaria. 
  • Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. 
  • Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Induction of superoxide anion and nitric oxide production in cultured microglia. 
  • Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics. 
  • Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed. 
  • Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. 
  • Influence of scaffold size on bactericidal activity of nitric oxide-releasing silica nanoparticles. 
  • Inhaled Nitric Oxide (iNO) and Inhaled Epoprostenol (iPGI2) Use in Cardiothoracic Surgical Patients: Is there Sufficient Evidence for Evidence-Based Recommendations? 
  • Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial. 
  • Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. 
  • Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. 
  • Inhaled nitric oxide after left ventricular assist device implantation: a prospective, randomized, double-blind, multicenter, placebo-controlled trial. 
  • Inhaled nitric oxide selectively dilates pulmonary vasculature in adult patients with pulmonary hypertension, irrespective of etiology. 
  • Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. 
  • Inhaled nitric oxide, right ventricular efficiency, and pulmonary vascular mechanics: selective vasodilation of small pulmonary vessels during hypoxic pulmonary vasoconstriction. 
  • Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. 
  • Inhibition of implant-associated infections via nitric oxide release. 
  • Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides. 
  • Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides. 
  • Inhibition of nitric oxide synthase by cobalamins and cobinamides. 
  • Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. 
  • Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. 
  • Inhibition of the inositol triphosphate receptor increases endotoxin-mediated nitric oxide synthesis in macrophages. 
  • Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo. 
  • Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes. 
  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. 
  • Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. 
  • Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes. 
  • Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. 
  • Just say NO to NLRP3. 
  • Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide. 
  • L-Citrulline increases nitric oxide and improves control in obese asthmatics. 
  • L-Met Activates Arabidopsis GLR Ca²⁺ Channels Upstream of ROS Production and Regulates Stomatal Movement. 
  • L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. 
  • L-arginine enhances injury in the isolated rabbit lung during hyperoxia. 
  • L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. 
  • L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake. 
  • Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. 
  • Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model. 
  • Location-dependent artifact for no measurement using multiwell plates. 
  • Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality. 
  • Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. 
  • Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury. 
  • Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. 
  • Management Practice and Mortality for Infants with Congenital Diaphragmatic Hernia. 
  • Management of Pulmonary Arterial Hypertension in the Pediatric Patient. 
  • Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple. 
  • Measuring nitric oxide production in human clinical studies. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mechanical ventilation strategies in the management of congenital diaphragmatic hernia. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Mechanisms of activation of the RAW264.7 macrophage cell line by transfected mammalian DNA. 
  • Mechanisms of cell death governed by the balance between nitrosative and oxidative stress. 
  • Mechanisms of the antioxidant effects of nitric oxide. 
  • Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. 
  • Methodologies for the characterization, identification and quantification of S-nitrosylated proteins. 
  • Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat. 
  • Microglial contribution to oxidative stress in Alzheimer's disease. 
  • Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. 
  • Mitochondria and nitric oxide. 
  • Mitochondrial Quality Control as a Therapeutic Target. 
  • Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. 
  • Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. 
  • Modeling early stage atherosclerosis in a primary human vascular microphysiological system. 
  • Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI. 
  • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. 
  • Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. 
  • Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. 
  • Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR). 
  • Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. 
  • Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs. 
  • N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. 
  • N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • NO inhibits hyperoxia-induced NF-κB activation in neonatal pulmonary microvascular endothelial cells. 
  • NO waiting to exhale in asthma. 
  • NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65. 
  • NOS2 regulation of NF-kappaB by S-nitrosylation of p65. 
  • Nasally Inhaled Nitric Oxide for Sudden Right-Sided Heart Failure in the Intensive Care Unit: NO Time Like the Present. 
  • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. 
  • Neural control of urethral outlet activity in vivo: role of nitric oxide. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • Neurotransmitter identity doubt. 
  • New insights into protein S-nitrosylation. Mitochondria as a model system. 
  • Nitrate levels in malaria. 
  • Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease. 
  • Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. 
  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy. 
  • Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. 
  • Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. 
  • Nitric oxide and redox mechanisms in the immune response. 
  • Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis. 
  • Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits. 
  • Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. 
  • Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes. 
  • Nitric oxide enhances salt secretion and Na+ sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H+-ATPase and Na+/H+ antiporter under high salinity 
  • Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. 
  • Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. 
  • Nitric oxide in brain death related cardiovascular dysfunction. 
  • Nitric oxide in glutamate-induced compound action potential threshold shifts. 
  • Nitric oxide in the human respiratory cycle. 
  • Nitric oxide inhibition of human sperm motility. 
  • Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages. 
  • Nitric oxide interactions with cobalamins: biochemical and functional consequences. 
  • Nitric oxide involvement in reperfusion injury of denervated muscle. 
  • Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. 
  • Nitric oxide is fundamental to neurovascular coupling in humans. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo. 
  • Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. 
  • Nitric oxide modulates branching morphogenesis in fetal rat lung explants. 
  • Nitric oxide modulates synaptic vesicle docking fusion reactions. 
  • Nitric oxide modulation of human leukemia cell differentiation and gene expression. 
  • Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. 
  • Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. 
  • Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. 
  • Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia. 
  • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitric oxide represses the Arabidopsis floral transition. 
  • Nitric oxide signaling: no longer simply on or off. 
  • Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. 
  • Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Nitric oxide synthase is an active enzyme in the spiral ganglion cells of the rat cochlea. 
  • Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. 
  • Nitric oxide synthase: role in the genesis of vascular disease. 
  • Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. 
  • Nitric oxide--friend or foe in arthritis? 
  • Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event. 
  • Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. 
  • Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity. 
  • Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. 
  • Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. 
  • Nitric oxide-producing polyurethanes. 
  • Nitric oxide-releasing polymeric microspheres improve diabetes-related erectile dysfunction. 
  • Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. 
  • Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth. 
  • Nitric oxide-releasing silica nanoparticle-doped polyurethane electrospun fibers. 
  • Nitric oxide: physiology and pharmacology. 
  • Nitrosation and oxidation in the regulation of gene expression. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. 
  • Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study. 
  • Nitrosylation of blood hemoglobin and renal nonheme proteins in autoimmune MRL-lpr/lpr mice. 
  • Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African Americans. 
  • O=O NO: it's CO. 
  • Obesity's effect on asthma extends to diagnostic criteria. 
  • Organ uptake and release of inorganic nitrate and nitrite in the pig. 
  • Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. 
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. 
  • Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. 
  • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. 
  • Oxidative stress, antioxidant defenses and nitric oxide production following hyperoxic exposures. 
  • Oxygen binding to partially nitrosylated hemoglobin. 
  • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. 
  • Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide. 
  • Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases. 
  • Oxygen, nitric oxide and articular cartilage. 
  • PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. 
  • Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. 
  • Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration. 
  • Perinatal factors associated with poor neurocognitive outcome in early school age congenital diaphragmatic hernia survivors. 
  • Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation. 
  • Pharmacological regulation of outflow resistance distal to Schlemm's canal. 
  • Pharmacological strategies for improving diastolic dysfunction in the setting of chronic pulmonary hypertension. 
  • Phenotypic characteristics and asthma severity in an East African cohort of adults and adolescents with asthma: findings from the African severe asthma project. 
  • Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. 
  • Plant Immunity Requires Conformational Changes of NPR1 via S-Nitrosylation and Thioredoxins 
  • Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. 
  • Pleural macrophage recruitment and activation in asbestos-induced pleural injury. 
  • Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination. 
  • Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages. 
  • Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. 
  • Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus. 
  • Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Protection from nitrosative stress by yeast flavohemoglobin. 
  • Protection from nitrosative stress: a central role for microbial flavohemoglobin. 
  • Protein S-nitrosylation in health and disease: a current perspective. 
  • Protein S-nitrosylation: purview and parameters. 
  • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. 
  • Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care. 
  • Pulmonary Delivery of Therapeutic and Diagnostic Gases. 
  • Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. 
  • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. 
  • Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. 
  • RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. 
  • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Redox regulation of mitochondrial biogenesis. 
  • Reduced foreign body response at nitric oxide-releasing subcutaneous implants. 
  • Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression. 
  • Regulation of HIF-1alpha stability through S-nitrosylation. 
  • Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. 
  • Regulation of cellular processes by S-nitrosylation. Preface. 
  • Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide. 
  • Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. 
  • Regulation of mitochondrial processes by protein S-nitrosylation. 
  • Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. 
  • Regulation of the brain's vascular responses to oxygen. 
  • Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. 
  • Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. 
  • Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death. 
  • Response to inhaled nitric oxide predicts survival in patients with pulmonary hypertension. 
  • Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. 
  • RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling. 
  • Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Role of circulating S-nitrosothiols in control of blood pressure. 
  • Role of nitric oxide in murine conventional outflow physiology. 
  • Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions. 
  • Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. 
  • Role of nonenzymatically generated prostanoid, 8-iso-PGF2 alpha, in pulmonary oxygen toxicity. 
  • Role of oxidants in microbial pathophysiology. 
  • Role of size and shape on biofilm eradication for nitric oxide-releasing silica nanoparticles. 
  • Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides. 
  • Round versus flat: bone cell morphology, elasticity, and mechanosensing. 
  • S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates. 
  • S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. 
  • S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. 
  • S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. 
  • S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action. 
  • S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. 
  • S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. 
  • S-nitrosylation TRiPs a calcium switch. 
  • S-nitrosylation in health and disease. 
  • S-nitrosylation in the regulation of gene transcription. 
  • S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures. 
  • S-nitrosylation of Ras in breast cancer. 
  • SNO-hemoglobin and hypoxic vasodilation. 
  • Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. 
  • Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Serial monitoring of exhaled nitric oxide in lung transplant recipients. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures. 
  • Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors. 
  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. 
  • Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. 
  • Shear stress-triggered nitric oxide release from Schlemm's canal cells. 
  • Sickness response symptoms among healthy volunteers after controlled exposures to diesel exhaust and psychological stress. 
  • Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. 
  • Smoking is associated with an age-related decline in exhaled nitric oxide. 
  • Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. 
  • Soluble guanylate cyclase: a potential therapeutic target for heart failure. 
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. 
  • Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis. 
  • Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. 
  • Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure. 
  • Structure and regulation of soluble guanylate cyclase. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Surface projections of titanium substrates increase antithrombotic endothelial function in response to shear stress. 
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. 
  • Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 
  • Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. 
  • TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. 
  • Tailoring nitric oxide release with additive manufacturing to create antimicrobial surfaces. 
  • Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. 
  • The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. 
  • The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants. 
  • The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry. 
  • The changes of nitric oxide production during the growth of Microcystis aerugrinosa. 
  • The chemical biology of nitric oxide: implications in cellular signaling. 
  • The decomposition of thionitrites. 
  • The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. 
  • The effects of adipokines on cartilage and meniscus catabolism. 
  • The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. 
  • The emerging multifaceted roles of nitric oxide. 
  • The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. 
  • The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. 
  • The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. 
  • The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines. 
  • The kidney and hypertension: novel insights from transgenic models. 
  • The multifaceted roles of nitric oxide in cancer. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use. 
  • The response to repeated nitric oxide inhalation is inconsistent in patients with acute respiratory distress syndrome. 
  • The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. 
  • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The systemic inflammatory response to cardiopulmonary bypass: pathophysiological, therapeutic, and pharmacological considerations. 
  • The use of supplemental hydrocortisone in the management of persistent pulmonary hypertension of the newborn. 
  • The vital role for nitric oxide in intraocular pressure homeostasis. 
  • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. 
  • Therapeutic potential of nitric oxide synthase gene manipulation. 
  • Therapies for refractory hypoxemia in acute respiratory distress syndrome. 
  • Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. 
  • Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. 
  • Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation. 
  • Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. 
  • Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. 
  • Treatment-related biomarkers in pulmonary hypertension patients on oral therapies. 
  • Treatment-related biomarkers in pulmonary hypertension. 
  • Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
  • Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. 
  • Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. 
  • Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline. 
  • Utilization of inhaled nitric oxide after surgical repair of truncus arteriosus: A multicenter analysis. 
  • Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. 
  • Vascular biology: the past 50 years. 
  • Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. 
  • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. 
  • Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications. 
  • Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. 
  • [Management of the acute respiratory distress syndrome]. 
  • [Recent advances in atherothrombotic diseases]. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. 
  • l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
• 

  Keywords of People

  • Bush, Margaret, Clinical Professor in the School of Nursing, School of Nursing
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Moon, Richard Edward, Professor of Anesthesiology, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Pastva, Amy Martha, Professor in Orthopaedic Surgery, Cell Biology