Nitrogen Isotopes

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  Subject Areas on Research

  • (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein. 
  • 13N,15N isotope and kinetic evidence against hyponitrite as an intermediate in dentrification. 
  • 15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant. 
  • 15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. 
  • A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. 
  • A refocused and optimized HNCA: increased sensitivity and resolution in large macromolecules. 
  • Application of ¹⁵ N₂ -Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP. 
  • Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. 
  • Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. 
  • Benthic and pelagic pathways of methylmercury bioaccumulation in estuarine food webs of the northeast United States. 
  • Biological nitrogen fixation by alternative nitrogenases in boreal cyanolichens: importance of molybdenum availability and implications for current biological nitrogen fixation estimates. 
  • Changes in stable isotopic signatures of soil nitrogen and carbon during 40 years of forest development. 
  • Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. 
  • Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms. 
  • Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs. 
  • Crab regulation of cross-ecosystem resource transfer by marine foraging fire ants. 
  • Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange. 
  • Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags. 
  • High-level 2H/13C/15N labeling of proteins for NMR studies. 
  • Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange. 
  • Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR. 
  • Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance. 
  • Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Is there foul play in the leaf pocket? The metagenome of floating fern Azolla reveals endophytes that do not fix N2 but may denitrify. 
  • Maintenance of native-like protein dynamics may not be required for engineering functional proteins. 
  • Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. 
  • NMR studies of nucleic acid dynamics. 
  • Organic nitrogen uptake of Scots pine seedlings is independent of current carbohydrate supply. 
  • Plant nitrogen concentration and isotopic composition in residential lawns across seven US cities. 
  • Preparation, resonance assignment, and preliminary dynamics characterization of residue specific 13C/15N-labeled elongated DNA for the study of sequence-directed dynamics by NMR. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Rapid determination of protein folds using residual dipolar couplings. 
  • Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. 
  • Spatial distribution of bottlenose dolphins (Tursiops truncatus) inferred from stable isotopes and priority organic pollutants. 
  • Stable isotope analyses reveal previously unknown trophic mode diversity in the Hymenochaetales. 
  • Stable isotope ratios indicate diet and habitat use in New World monkeys. 
  • Terminal Diazirines Enable Reverse Polarization Transfer from ¹⁵ N₂ Singlets. 
  • The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis". 
  • Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II. 
  • Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange. 
  • Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings. 
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  Keywords of People

  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science