Nociceptors

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  Subject Areas on Research

  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A craniofacial-specific monosynaptic circuit enables heightened affective pain. 
  • A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. 
  • Acid potentiation of the capsaicin receptor determined by a key extracellular site. 
  • Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury. 
  • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. 
  • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. 
  • Cell signaling and the genesis of neuropathic pain. 
  • Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist. 
  • Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Glial cells and chronic pain. 
  • Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. 
  • IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice. 
  • IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis. 
  • Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions. 
  • Intracellular signaling in primary sensory neurons and persistent pain. 
  • Ion channels in analgesia research. 
  • Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. 
  • MAP kinase and pain. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. 
  • Neuroanatomical relationships of substance P-immunoreactive intrapulmonary C-fibers and nicotinic cholinergic receptors. 
  • Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Nociceptors are interleukin-1beta sensors. 
  • OnabotulinumtoxinA effects on trigeminal nociceptors. 
  • Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain? 
  • Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. 
  • Pungent products from garlic activate the sensory ion channel TRPA1. 
  • Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. 
  • Recent progress in understanding the mechanisms of pain and itch. 
  • Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. 
  • Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Responses of monkey medullary dorsal horn neurons during the detection of noxious heat stimuli. 
  • Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays. 
  • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. 
  • Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. 
  • Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. 
  • Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. 
  • The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. 
  • The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. 
  • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. 
  • The role of thrombin and protease-activated receptors in pain mechanisms. 
  • The symptoms of osteoarthritis and the genesis of pain. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • [Induction of Fos-like protein in the rat spinal cord following electroacupuncture stimulation]. 
  • [Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain]. 
  • [Proto-oncogene and pain modulation]. 
  • miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
  • p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. 
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  Keywords of People

  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology