Notochord
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Subject Areas on Research
- BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.
- Changes in gravitational force induce alterations in gene expression that can be monitored in the live, developing zebrafish heart.
- Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo.
- Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.
- Development of a straight vertebrate body axis.
- Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
- Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat.
- Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements.
- Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33.
- Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
- Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.
- Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.
- Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis.
- Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.
- Spine Patterning Is Guided by Segmentation of the Notochord Sheath.
- The vacuole within: how cellular organization dictates notochord function.
- Tissue self-organization underlies morphogenesis of the notochord.
- Twist is an integrator of SHH, FGF, and BMP signaling.
- Why is female sex an independent predictor of shortened overall survival after proton/photon radiation therapy for skull base chordomas?
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Keywords of People
- Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology