Nucleic Acids

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  Subject Areas on Research

  • A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens. 
  • Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics. 
  • Barnacle biology before, during and after settlement and metamorphosis: a study of the interface. 
  • Biosensors and biochips: advances in biological and medical diagnostics. 
  • Boranophosphate nucleic acids--a versatile DNA backbone. 
  • DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists. 
  • Developing aptamers into therapeutics. 
  • Development and application of aromatic [(13)C, (1)H] SOFAST-HMQC NMR experiment for nucleic acids. 
  • Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids. 
  • Editorial overview: Nucleic acids and their protein complexes: Progress in nucleic acid structural biology: new technologies and discoveries. 
  • Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes. 
  • Effects of maternal nicotine injections on brain development in the rat: ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions. 
  • Exploring molecular diversity with combinatorial shape libraries. 
  • Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. 
  • Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy. 
  • MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes. 
  • Mass spectrometry of nucleic acids: the promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry. 
  • Maximizing utilization of the donor pool by appropriate classification of hepatitis C antibody-positive donors. 
  • MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. 
  • MolProbity: all-atom structure validation for macromolecular crystallography. 
  • NMR studies of nucleic acid dynamics. 
  • New tools and data for improving structures, using all-atom contacts. 
  • Nucleic Acid Delivery from Granular Hydrogels. 
  • Nucleic acid aptamers as adjuncts to vaccine development. 
  • Nucleic acid scavengers inhibit thrombosis without increasing bleeding. 
  • Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Nucleic acid-binding polymers as anti-inflammatory agents: reducing the danger of nuclear attack. 
  • Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis. 
  • Plasmonic coupling interference (PCI) nanoprobes for nucleic acid detection. 
  • Polycationic Nanofibers for Nucleic Acid Scavenging. 
  • Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. 
  • Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways. 
  • Scavenging nucleic acid debris to combat autoimmunity and infectious disease. 
  • Steering electrons on moving pathways. 
  • Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver- a morphological and biochemical study. 
  • Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. 
  • Targeting DAMPs with nucleic acid scavengers to treat lupus. 
  • Test-of-Cure After Treatment of Pharyngeal Gonorrhea in Durham, North Carolina, 2021-2022. 
  • The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation. 
  • The central role of nucleic acids in the pathogenesis of systemic lupus erythematosus. 
  • The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction. 
  • The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. 
  • Therapeutic Aptamers: Evolving to Find their Clinical Niche. 
  • Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • Voltage-induced long-range coherent electron transfer through organic molecules. 
  • β-Cyclodextrin-containing polymer treatment of cutaneous lupus and influenza improves outcomes.