Nucleotides

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  Subject Areas on Research

  • A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. 
  • ADPase activity of recombinantly expressed thermotolerant ATPases may be caused by copurification of adenylate kinase of Escherichia coli. 
  • Actin regulation and surface catalysis. 
  • Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes. 
  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. 
  • Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant. 
  • An improved method of isolation and determination of cordycepin. 
  • Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. 
  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. 
  • Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. 
  • Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. 
  • Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. 
  • Breaking symmetry in multimeric ATPase motors. 
  • Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. 
  • Characterization of nucleotide binding sites on chloroplast coupling factor 1. 
  • Characterization of the usage of the serine metabolic network in human cancer. 
  • Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. 
  • Chemistry and biology of the molybdenum cofactors. 
  • Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. 
  • Comparison of the Euglena chloroplast protein synthesizing system with those of prokaryotes and eukaryotes. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Creatine kinase: essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry. 
  • Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. 
  • Developmental Biology: Embryos Need to Control Their Nucleotides Just Right. 
  • Differential labelling of UDP-N-acetylglucosamine in Huntington's-chorea fibroblasts. 
  • Dissociation between early recovery of regional function and purine nucleotide content in postischaemic myocardium in the conscious dog. 
  • Effects of fatty acid composition on the sensitivity of membrane functions to ethanol in Escherichia coli. 
  • Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. 
  • Elongation by Drosophila RNA polymerase II. Transcription of 3'-extended DNA templates. 
  • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. 
  • Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase. 
  • For Embryos, Mother Can Only Take You So Far. 
  • GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. 
  • Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hepatitis B surface antigen (HBsAg) decrease and serum interferon-inducible protein-10 levels as predictive markers for HBsAg loss during treatment with nucleoside/nucleotide analogues. 
  • Homocitrullylaminoadenosine, a nucleoside isolated from Cordyceps militaris. 
  • Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. 
  • Improved method for high energy nucleotide analysis of canine cardiac muscle using reversed-phase high-performance liquid chromatography. 
  • In vitro synthesis of phi-X-174 single-stranded DNA. 
  • Inhibition of Ehrlich mouse ascites tumor growth by cordycepin. 
  • Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design. 
  • Investigation of nucleotide binding sites on chloroplast coupling factor 1 with 3'O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. 
  • Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells. 
  • Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. 
  • Motor proteins 1: kinesins. 
  • Multilocus patterns of nucleotide diversity, population structure and linkage disequilibrium in Boechera stricta, a wild relative of Arabidopsis. 
  • Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone. 
  • Multiple and specific initiation of T4 DNA replication. 
  • Multiple effects of guanine nucleotides on human platelet adenylated cyclase. 
  • Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22. 
  • Nucleotide pool in pho regulon mutants and alkaline phosphatase synthesis in Escherichia coli. 
  • Nucleotide-induced asymmetry within ATPase activator ring drives σ54-RNAP interaction and ATP hydrolysis. 
  • Nutritional support in critically ill patients. 
  • Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Phylogenetic relationships of the liverworts (Hepaticae), a basal embryophyte lineage, inferred from nucleotide sequence data of the chloroplast gene rbcL. 
  • Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. 
  • Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations. 
  • Prolonged myocardial nucleotide depletion after brief ischemia in the open-chest dog. 
  • Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes. 
  • Pseudobond parameters for QM/MM studies involving nucleosides, nucleotides, and their analogs. 
  • Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate. 
  • RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. 
  • Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. 
  • Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection. 
  • Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme. 
  • Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. 
  • Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. 
  • Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. 
  • Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales. 
  • Simple step gradient elution of the major high-energy compounds and their catabolites in cardiac muscle using high-performance liquid chromatography. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Structural mapping of chloroplast coupling factor. 
  • Structural mapping of nucleotide binding sites on chloroplast coupling factor. 
  • Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction. 
  • Structures of mismatch replication errors observed in a DNA polymerase. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • Studies on the biosynthesis of cordycepin. 
  • Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct. 
  • Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase. 
  • Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. 
  • Synthesis of new classes of boron-containing nucleotides. 
  • Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. 
  • Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage. 
  • Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. 
  • Terminal sequences of vesicular stomatitis virus RNA are both complementary and conserved. 
  • The Closing Mechanism of DNA Polymerase I at Atomic Resolution. 
  • The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo. 
  • The effects of nucleotide substitution model assumptions on estimates of nonparametric bootstrap support. 
  • The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation. 
  • Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development.