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Subject Areas on Research
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A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing.
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A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.
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Actin regulation and surface catalysis.
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Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.
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Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase.
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Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant.
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Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents.
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Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity.
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Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae.
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Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons.
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Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
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Characterization of nucleotide binding sites on chloroplast coupling factor 1.
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Characterization of the usage of the serine metabolic network in human cancer.
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Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.
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Chemistry and biology of the molybdenum cofactors.
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Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site.
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Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine.
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Creatine kinase: essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry.
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Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment.
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Developmental Biology: Embryos Need to Control Their Nucleotides Just Right.
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Differential labelling of UDP-N-acetylglucosamine in Huntington's-chorea fibroblasts.
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Dissociation between early recovery of regional function and purine nucleotide content in postischaemic myocardium in the conscious dog.
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Effects of fatty acid composition on the sensitivity of membrane functions to ethanol in Escherichia coli.
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Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy.
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Elongation by Drosophila RNA polymerase II. Transcription of 3'-extended DNA templates.
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Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.
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Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.
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Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase.
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Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1.
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Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
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For Embryos, Mother Can Only Take You So Far.
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GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability.
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Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.
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Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.
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Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.
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Hypolipidemic activity of boronated nucleosides and nucleotides in rodents.
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In vitro synthesis of phi-X-174 single-stranded DNA.
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Investigation of nucleotide binding sites on chloroplast coupling factor 1 with 3'O-(4-benzoyl)benzoyl adenosine 5'-triphosphate.
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Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations.
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Kinesin: switch I & II and the motor mechanism.
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Mapping of copper/hydrogen peroxide-induced DNA damage at nucleotide resolution in human genomic DNA by ligation-mediated polymerase chain reaction.
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Mapping oxidative DNA damage at nucleotide level.
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Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells.
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Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.
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Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.
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Motor proteins 1: kinesins.
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Multilocus patterns of nucleotide diversity, population structure and linkage disequilibrium in Boechera stricta, a wild relative of Arabidopsis.
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Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone.
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Multiple and specific initiation of T4 DNA replication.
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Multiple effects of guanine nucleotides on human platelet adenylated cyclase.
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NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.
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Non-canonical genomic driver mutations of urethane carcinogenesis.
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Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22.
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Nucleotide pool in pho regulon mutants and alkaline phosphatase synthesis in Escherichia coli.
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Nutritional support in critically ill patients.
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Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases.
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Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide.
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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.
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Phylogenetic relationships of the liverworts (Hepaticae), a basal embryophyte lineage, inferred from nucleotide sequence data of the chloroplast gene rbcL.
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Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid.
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Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations.
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Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes.
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Pseudobond parameters for QM/MM studies involving nucleosides, nucleotides, and their analogs.
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Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate.
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RIPK3: Beyond Necroptosis.
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RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme.
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Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA.
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Regulation of cation channels in liver cells by intracellular calcium and protein kinase C.
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Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins.
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Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection.
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Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme.
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Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis.
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Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.
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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.
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Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Structural mapping of chloroplast coupling factor.
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Structural mapping of nucleotide binding sites on chloroplast coupling factor.
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Structures of mismatch replication errors observed in a DNA polymerase.
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Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold.
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Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct.
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Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase.
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Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.
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Synthesis of new classes of boron-containing nucleotides.
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Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.
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Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.
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Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.
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Terminal sequences of vesicular stomatitis virus RNA are both complementary and conserved.
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The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
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The Closing Mechanism of DNA Polymerase I at Atomic Resolution.
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The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.
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The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.
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The effects of nucleotide substitution model assumptions on estimates of nonparametric bootstrap support.
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The identification and characterization of a G4-DNA resolvase activity.
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Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics.
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V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development.
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Widespread false gene gains caused by duplication errors in genome assemblies.