Nucleus Accumbens

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  Subject Areas on Research

  • A genetically defined insula-brainstem circuit selectively controls motivational vigor. 
  • A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans. 
  • A role for ΔFosB in calorie restriction-induced metabolic changes. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Activity patterns in mesolimbic regions in rats during operant tasks for reward. 
  • Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. 
  • Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction. 
  • Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat. 
  • Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. 
  • Antidepressant actions of histone deacetylase inhibitors. 
  • Appetitive changes during salt deprivation are paralleled by widespread neuronal adaptations in nucleus accumbens, lateral hypothalamus, and central amygdala. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Behavioral, but not reward, risk modulates activation of prefrontal, parietal, and insular cortices. 
  • Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studies. 
  • Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. 
  • Cocaine increases stimulated dopamine release more in periadolescent than adult rats. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Cocaine shapes chromatin landscapes via Tet1. 
  • Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. 
  • Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. 
  • Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy. 
  • Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior. 
  • Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior. 
  • Early nurture epigenetically tunes the oxytocin receptor. 
  • Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. 
  • Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. 
  • Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus. 
  • FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration. 
  • Feedback-Based Learning in Aging: Contributions and Trajectories of Change in Striatal and Hippocampal Systems. 
  • Food reward in the absence of taste receptor signaling. 
  • Genetic Risk for Rheumatoid Arthritis is Associated with Increased Striatal Volume in Healthy Young Adults. 
  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression. 
  • Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls. 
  • Impact of acute nicotine exposure on monoaminergic systems in adolescent and adult male and female rats. 
  • Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. 
  • LTP in the mouse nucleus accumbens is developmentally regulated. 
  • Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. 
  • MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. 
  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. 
  • Morphine exposure alters Fos expression in a sex-, age-, and brain region-specific manner during adolescence. 
  • Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. 
  • Multimodal characterization of the human nucleus accumbens. 
  • Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • Neurotensin interacts with dopaminergic neurons in rat brain. 
  • Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens. 
  • Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats. 
  • Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. 
  • Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. 
  • Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. 
  • Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. 
  • Prefrontal cortex output circuits guide reward seeking through divergent cue encoding. 
  • Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring. 
  • ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. 
  • Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. 
  • Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice. 
  • Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. 
  • Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. 
  • Reward-motivated learning: mesolimbic activation precedes memory formation. 
  • Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions. 
  • Subcortical shape in pediatric and adult obsessive-compulsive disorder. 
  • Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder. 
  • Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. 
  • Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. 
  • The neural underpinnings of how reward associations can both guide and misguide attention. 
  • The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history. 
  • Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates. 
  • Transitions between sleep and feeding states in rat ventral striatum neurons. 
  • TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine. 
  • Variability in nucleus accumbens activity mediates age-related suboptimal financial risk taking. 
  • White-Matter Tract Connecting Anterior Insula to Nucleus Accumbens Correlates with Reduced Preference for Positively Skewed Gambles. 
  • Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. 
  • fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder. 
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  Keywords of People

  • Huettel, Scott, Professor in the Department of Psychology and Neuroscience, Duke Science & Society