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Subject Areas on Research
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2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
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68Ga-PSMA PET/CT and PET/MRI in high-risk prostate cancer patients.
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A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Rett Syndrome.
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A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.
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A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides.
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A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.
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A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.
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A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway.
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A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma.
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A phase I study of ABT-510 plus bevacizumab in advanced solid tumors.
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A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer.
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A single step purification for autolytic zinc proteinases.
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A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.
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ALSUntangled No. 34: GM604.
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Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
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Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.
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Activin A and follistatin are dynamically regulated during human pregnancy.
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Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics.
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Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis.
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Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants.
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Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death.
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Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes.
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An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts.
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Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials.
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Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy.
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Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.
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Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients.
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Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH.
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Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
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Assembly of a chemically synthesized peptide of Escherichia coli type 1 fimbriae into fimbria-like antigenic structures.
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BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth.
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Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin.
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Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF).
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Binding site on human immunoglobulin G for the affinity ligand HWRGWV.
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Biocompatible hydrogels by oxime Click chemistry
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Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism.
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Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation.
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CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.
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CLT1 targets bladder cancer through integrin α5β1 and CLIC3.
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CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.
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Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.
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Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.
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Cancer cachexia: Are we ready to take a step forward?
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Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface.
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Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial.
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Carfilzomib, pomalidomide, and dexamethasone for relapsed or refractory myeloma.
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Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture.
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Cascading "Triclick" functionalization of poly(caprolactone) thin films quantified via a quartz crystal microbalance.
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Cell migration through defined, synthetic ECM analogs.
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Cell-Compatible, Site-Specific Covalent Modification of Hydrogel Scaffolds Enables User-Defined Control over Cell-Material Interactions.
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Cellular immune response to cryptic epitopes during therapeutic gene transfer.
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Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study.
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Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation.
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Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells.
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Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand.
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Chemically Orthogonal Protein Ligation Domains for Independent Control of Hydrogel Modification with Adhesive Ligands and Growth Factors.
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Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.
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Chemoattractant receptor affinity reflects its ability to transduce different biological responses.
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Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
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Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line.
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Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.
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Clinical results in cachexia therapeutics.
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Clustered Arg–Gly–Asp peptides enhances tumor targeting of nonviral vectors
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Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric Env protein boost in the SHIV rhesus macaque model.
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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
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Concentration-Dependent hMSC Differentiation on Orthogonal Concentration Gradients of GRGDS and BMP-2 Peptides.
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Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.
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Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells.
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Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration.
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Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells.
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Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels.
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Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.
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Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes.
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D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination.
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Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis.
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Demonstration of a chemotactic factor receptor on macrophages.
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Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry.
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Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization.
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Development of bioactive photocrosslinkable fibrous hydrogels.
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Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity.
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Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines.
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Diabetes mellitus and advanced liver fibrosis are risk factors for severe anaemia during telaprevir-based triple therapy.
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Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity.
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Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide.
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Directed intermixing in multicomponent self-assembling biomaterials.
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Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
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Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.
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Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.
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Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice.
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Dynamic seeding of perfusing human umbilical vein endothelial cells (HUVECs) onto dual-function cell adhesion ligands: Arg-Gly-Asp (RGD)-streptavidin and biotinylated fibronectin.
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Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
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Economic evaluation of direct-acting antiviral therapy in chronic hepatitis C.
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Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
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Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy.
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Effect of receptor-ligand affinity on the strength of endothelial cell adhesion.
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Effect of streptavidin RGD mutant on the adhesion of endothelial cells.
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Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion.
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Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia.
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Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.
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Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia.
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Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals.
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Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
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Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats.
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Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.
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Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea.
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Engineering clustered ligand binding into nonviral vectors: αvβ3 targeting as an example
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Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.
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Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes.
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Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
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Evaluation of a novel kallikrein inhibitor on hemostatic activation in vitro.
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Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK.
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Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.
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Evolving the use of peptides as components of biomaterials
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Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.
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Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
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Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer.
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Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.
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Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering.
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Extrinsic pathway proteolytic activity.
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FSH suppression and tumour control in patients with prostate cancer during androgen deprivation with a GnRH agonist or antagonist.
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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB.
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Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung.
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Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma.
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Fluorescence studies on modes of cytochalasin B and phallotoxin action on cytoplasmic streaming in Chara.
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Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.
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Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.
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Frequency of atazanavir-associated leukocyturia development and renal function decline.
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G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
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GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.
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Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.
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Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses.
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Glycophase glass revisited: protein adsorption and cell growth on glass surfaces bearing immobilized glycerol monosaccharides.
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Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study.
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Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.
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H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.
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Heparin oligosaccharides enhance tissue-type plasminogen activator: a correlation between oligosaccharide length and stimulation of plasminogen activation.
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High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays.
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Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.
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Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.
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Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation
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IL28B in the era of direct-acting antivirals for hepatitis C.
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Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic.
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Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
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Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.
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Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase.
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Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.
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Identification of two ancillary subunits of Escherichia coli type 1 fimbriae by using antibodies against synthetic oligopeptides of fim gene products.
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Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.
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In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.
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Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.
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Induction of selective biological responses to chemoattractants in a human monocyte-like cell line.
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Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels.
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Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.
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Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus.
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Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
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Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases.
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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
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Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287.
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Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
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Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance.
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Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms.
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Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program.
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Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase.
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Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels.
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Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction.
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Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue.
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Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.
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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
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Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
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Is renin a factor in the etiology of essential hypertension?
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Is the HCV pipeline heading in the right direction?
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Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.
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Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.
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Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection.
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Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers.
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Levels of p53 protein increase with maturation in human hematopoietic cells.
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Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
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Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.
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Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
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Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels.
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Mechanisms of ischemic injury are different in the steatotic and normal rat liver.
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Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.
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Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor.
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Microassay for the photometric quantitation of cell-associated plasminogen activator using a chromogenic tripeptide substrate.
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Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses.
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Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis.
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Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
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Microsomal membranes contain a high affinity binding site for prenylated peptides.
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Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations.
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Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain.
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Molecular description of the LCST behavior of an elastin-like polypeptide.
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Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants.
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Multicenter, dose-ranging study of efegatran sulfate versus heparin with thrombolysis for acute myocardial infarction: The Promotion of Reperfusion in Myocardial Infarction Evolution (PRIME) trial.
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Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling.
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Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
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Multifunctional thermally transitioning oligopeptides prepared by ring-opening metathesis polymerization.
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Multiple myeloma, version 1.2013.
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Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages.
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N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis.
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N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
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Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies.
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Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II.
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Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.
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Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion.
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Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.
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Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.
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Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors.
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Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients.
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Optical coding of mammalian cells using semiconductor quantum dots.
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Optical sensor for the detection of caspase-9 activity in a single cell.
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Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.
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Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells.
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Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells.
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury.
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PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.
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Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials.
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Peripheral T-cell lymphoma, NOS, and anaplastic large cell lymphoma.
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Pharmacologic manipulation of leukocyte chemotaxis. Present knowledge and future trends.
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Phase 1 study of PSMA ADC, an antibody-drug conjugate targeting prostate-specific membrane antigen, in chemotherapy-refractory prostate cancer.
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Phase 1 trial of ibrutinib and carfilzomib combination therapy for relapsed or relapsed and refractory multiple myeloma.
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Phase II study of dolastatin-10 as first-line treatment for advanced colorectal cancer.
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Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers.
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Phospholipid methylation in macrophages is inhibited by chemotactic factors.
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Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
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Photolithographic patterning of polyethylene glycol hydrogels.
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Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.
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Population pharmacokinetics of NNZ-2566 in healthy subjects.
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Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR.
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Postfabrication Tethering of Molecular Gradients on Aligned Nanofibers of Functional Poly(ε-caprolactone)s.
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Potent inhibition of HIV type 1 infection of mononuclear phagocytes by synthetic peptide analogs of HIV type 1 protease substrates.
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Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.
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Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.
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Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.
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Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.
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Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient.
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Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
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Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma.
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Prostate cancer: making the switch from LHRH antagonist to LHRH agonist.
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Protease-activated receptor-2 signaling triggers dendritic cell development.
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Purification and chemical characterization of melittin and acetylated derivatives.
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Quantification of in vitro endothelial cell adhesion to vascular graft material.
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Quantitation of dolastatin-10 using HPLC/electrospray ionization mass spectrometry: application in a phase I clinical trial.
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Quantum mechanics simulation of protein dynamics on long timescale.
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RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis.
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RGD-Functionalized Nanofibers Increase Early GFAP Expression during Neural Differentiation of Mouse Embryonic Stem Cells.
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Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody.
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Rapid optimization of enzyme substrates using defined substrate mixtures.
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Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
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Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors.
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Regulatory mechanisms of a chemoattractant receptor on leukocytes.
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Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF.
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Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.
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Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.
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Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells.
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Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response.
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SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques.
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Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET.
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Section Editor's Notebook: Prostate Cancer Theranosis in Clinical Practice and in Clinical Trials-68Ga-Prostate-Specific Member Antigen (PSMA)-11 PET/CT and 177Lu-PSMA-617 Therapy.
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Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation.
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Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope.
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Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies.
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Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands.
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Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates.
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Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.
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Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
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Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold.
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Structural basis of the intrasteric regulation of myosin light chain kinases.
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Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
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Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
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Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.
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Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.
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Superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone.
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Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.
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Surface-and hydrogel-mediated delivery of nucleic acid nanoparticles
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Sustained virologic response rates with telaprevir-based therapy in treatment-naive patients evaluated by race or ethnicity.
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Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.
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Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery
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Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.
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Synthetic peptide inhibitors of prorenin activation.
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Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.
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Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.
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Telaprevir for previously treated chronic HCV infection.
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Telaprevir for previously untreated chronic hepatitis C virus infection.
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Telaprevir for the treatment of chronic hepatitis C infection.
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Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection.
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Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling.
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The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
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The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
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The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.
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The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.
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The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy.
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The modulation of MSC integrin expression by RGD presentation
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The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates.
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The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol.
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The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase.
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The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation.
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The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels
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Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.
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Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
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Tissue plasminogen activator and thrombin generation measurements using the Thrombinoscope.
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Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.
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Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
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Treatment of rheumatoid arthritis with a DR4/1 peptide.
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Treatment patterns, health care resource utilization, and costs in U.S. patients diagnosed with chronic hepatitis C infection who received telaprevir or boceprevir.
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Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.
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Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer.
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Twenty-five year evolution of medical hormonal therapy for prostate cancer.
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Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli.
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Urolithiasis under atazanavir boosted and tenofovir therapy: a case report.
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Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.
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Utility of LHRH antagonists for advanced prostate cancer.
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Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.
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Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
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Val-ala-pro-gly, an elastin-derived non-integrin ligand: smooth muscle cell adhesion and specificity.
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Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir.
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Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.
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Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury.
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[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
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[GIPC: a new target for therapy in pancreatic adenocarcinoma?].
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alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.
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cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8).
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d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution.
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β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Chitneni, Satish K.,
Associate Professor in Radiology,
Radiology
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Cianciolo, George James,
Associate Professor Emeritus of Pathology,
Pathology
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Erickson, Harold Paul,
James B. Duke Distinguished Professor Emeritus,
Cell Biology
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Taylor, Gregory Alan,
Professor in Medicine,
Integrative Immunobiology
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Zennadi, Rahima,
Associate Professor in Medicine,
Pathology