Oligopeptides

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  Subject Areas on Research

  • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. 
  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides. 
  • A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments. 
  • A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. 
  • A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway. 
  • A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma. 
  • A phase I study of ABT-510 plus bevacizumab in advanced solid tumors. 
  • A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. 
  • A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men. 
  • A single step purification for autolytic zinc proteinases. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • ALSUntangled No. 34: GM604. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Activin A and follistatin are dynamically regulated during human pregnancy. 
  • Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics. 
  • Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. 
  • Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. 
  • Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes. 
  • An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts. 
  • Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome. 
  • Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. 
  • Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Assembly of a chemically synthesized peptide of Escherichia coli type 1 fimbriae into fimbria-like antigenic structures. 
  • BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF). 
  • Biocompatible hydrogels by oxime Click chemistry. 
  • Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. 
  • CLT1 targets bladder cancer through integrin α5β1 and CLIC3. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. 
  • Cancer cachexia: Are we ready to take a step forward? 
  • Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Carfilzomib, pomalidomide, and dexamethasone for relapsed or refractory myeloma. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Cell migration through defined, synthetic ECM analogs. 
  • Cellular immune response to cryptic epitopes during therapeutic gene transfer. 
  • Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study. 
  • Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells. 
  • Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand. 
  • Chemoattractant receptor affinity reflects its ability to transduce different biological responses. 
  • Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers. 
  • Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line. 
  • Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. 
  • Clinical results in cachexia therapeutics. 
  • Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors. 
  • Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric Env protein boost in the SHIV rhesus macaque model. 
  • Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. 
  • Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells. 
  • Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration. 
  • Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells. 
  • Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. 
  • Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 
  • Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. 
  • D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Demonstration of a chemotactic factor receptor on macrophages. 
  • Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry. 
  • Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization. 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Diabetes mellitus and advanced liver fibrosis are risk factors for severe anaemia during telaprevir-based triple therapy. 
  • Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Do antagonists of pancreatic cholecystokinin receptors interact with central nervous system cholecystokinin receptors? 
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy. 
  • Dynamic seeding of perfusing human umbilical vein endothelial cells (HUVECs) onto dual-function cell adhesion ligands: Arg-Gly-Asp (RGD)-streptavidin and biotinylated fibronectin. 
  • Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. 
  • Economic evaluation of direct-acting antiviral therapy in chronic hepatitis C. 
  • Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. 
  • Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy. 
  • Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. 
  • Effect of streptavidin RGD mutant on the adhesion of endothelial cells. 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia. 
  • Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. 
  • Efficacy and tolerability of telaprevir for chronic hepatitis virus C genotype 1 infection: a meta-analysis. 
  • Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals. 
  • Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea. 
  • Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example. 
  • Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes. 
  • Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. 
  • Evaluation of a novel kallikrein inhibitor on hemostatic activation in vitro. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance. 
  • Evolving the use of peptides as components of biomaterials. 
  • Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. 
  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. 
  • Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. 
  • Extrinsic pathway proteolytic activity. 
  • False-Positive Pancreatic Uptake Detected on 68Ga-PSMA PET/CT: A Priority Changing Incidental Finding While Assessing the Need for a Prostate Biopsy. 
  • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Fluorescence studies on modes of cytochalasin B and phallotoxin action on cytoplasmic streaming in Chara. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Frequency of atazanavir-associated leukocyturia development and renal function decline. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. 
  • Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. 
  • Glycophase glass revisited: protein adsorption and cell growth on glass surfaces bearing immobilized glycerol monosaccharides. 
  • Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. 
  • H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. 
  • Hapten addition to an MHC class I-binding peptide causes substantial adjustments of the TCR structure of the responding CD8(+) T cells. 
  • Heparin oligosaccharides enhance tissue-type plasminogen activator: a correlation between oligosaccharide length and stimulation of plasminogen activation. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. 
  • IL28B in the era of direct-acting antivirals for hepatitis C. 
  • Identification and characterization of a galactosyl peptide mimetic. Implications for use in removing xenoreactive anti-A Gal antibodies. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of a 21 amino acid peptide conferring 3-hydroxypropionic acid stress-tolerance to Escherichia coli. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. 
  • Identification of two ancillary subunits of Escherichia coli type 1 fimbriae by using antibodies against synthetic oligopeptides of fim gene products. 
  • Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. 
  • Induction of selective biological responses to chemoattractants in a human monocyte-like cell line. 
  • Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. 
  • Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287. 
  • Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. 
  • Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance. 
  • Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms. 
  • Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program. 
  • Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase. 
  • Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. 
  • Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. 
  • Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue. 
  • Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization. 
  • Is renin a factor in the etiology of essential hypertension? 
  • Is the HCV pipeline heading in the right direction? 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection. 
  • Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers. 
  • Levels of p53 protein increase with maturation in human hematopoietic cells. 
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. 
  • Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide. 
  • Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. 
  • Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. 
  • Mechanisms of ischemic injury are different in the steatotic and normal rat liver. 
  • Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling. 
  • Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor. 
  • Microassay for the photometric quantitation of cell-associated plasminogen activator using a chromogenic tripeptide substrate. 
  • Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain. 
  • Molecular description of the LCST behavior of an elastin-like polypeptide. 
  • Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants. 
  • Multicenter, dose-ranging study of efegatran sulfate versus heparin with thrombolysis for acute myocardial infarction: The Promotion of Reperfusion in Myocardial Infarction Evolution (PRIME) trial. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multifunctional thermally transitioning oligopeptides prepared by ring-opening metathesis polymerization. 
  • Multiple myeloma, version 1.2013. 
  • Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module. 
  • N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis. 
  • Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies. 
  • Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II. 
  • Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. 
  • Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. 
  • Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis. 
  • Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide. 
  • Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. 
  • Optical coding of mammalian cells using semiconductor quantum dots. 
  • Optical sensor for the detection of caspase-9 activity in a single cell. 
  • Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay. 
  • Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. 
  • Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials. 
  • Peripheral T-cell lymphoma, NOS, and anaplastic large cell lymphoma. 
  • Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. 
  • Pharmacologic manipulation of leukocyte chemotaxis. Present knowledge and future trends. 
  • Phase II study of dolastatin-10 as first-line treatment for advanced colorectal cancer. 
  • Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers. 
  • Phospholipid methylation in macrophages is inhibited by chemotactic factors. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Photolithographic patterning of polyethylene glycol hydrogels. 
  • Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. 
  • Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. 
  • Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. 
  • Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR. 
  • Potent inhibition of HIV type 1 infection of mononuclear phagocytes by synthetic peptide analogs of HIV type 1 protease substrates. 
  • Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 
  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma. 
  • Prostate cancer: making the switch from LHRH antagonist to LHRH agonist. 
  • Protease-activated receptor-2 signaling triggers dendritic cell development. 
  • Purification and chemical characterization of melittin and acetylated derivatives. 
  • Quantification of in vitro endothelial cell adhesion to vascular graft material. 
  • Quantitation of dolastatin-10 using HPLC/electrospray ionization mass spectrometry: application in a phase I clinical trial. 
  • Quantum mechanics simulation of protein dynamics on long timescale. 
  • RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis. 
  • ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small-cell lung cancer (NSCLC) patients with cachexia. 
  • Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody. 
  • Rapid optimization of enzyme substrates using defined substrate mixtures. 
  • Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. 
  • Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. 
  • Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. 
  • Regulatory mechanisms of a chemoattractant receptor on leukocytes. 
  • Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF. 
  • Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. 
  • Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice. 
  • Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells. 
  • Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. 
  • Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET. 
  • Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation. 
  • Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands. 
  • Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates. 
  • Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans. 
  • Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. 
  • Specificity of peptide binding by the HLA-A2.1 molecule. 
  • Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice? 
  • Strongly binding cell-adhesive polypeptides of programmable valencies. 
  • Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold. 
  • Structural basis of the intrasteric regulation of myosin light chain kinases. 
  • Structural insights into inhibition of lipid I production in bacterial cell wall synthesis. 
  • Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone. 
  • Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Surface- and hydrogel-mediated delivery of nucleic acid nanoparticles. 
  • Sustained virologic response rates with telaprevir-based therapy in treatment-naive patients evaluated by race or ethnicity. 
  • Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery. 
  • Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. 
  • Synthetic peptide inhibitors of prorenin activation. 
  • Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. 
  • Telaprevir for previously treated chronic HCV infection. 
  • Telaprevir for previously untreated chronic hepatitis C virus infection. 
  • Telaprevir for the treatment of chronic hepatitis C infection. 
  • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • Testosterone administration suppresses adiponectin levels in men. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. 
  • The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. 
  • The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. 
  • The modulation of MSC integrin expression by RGD presentation. 
  • The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol. 
  • The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase. 
  • The role of melanin-concentrating hormone in conditioned reward learning. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. 
  • Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. 
  • Tissue plasminogen activator and thrombin generation measurements using the Thrombinoscope. 
  • Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis. 
  • Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. 
  • Treatment of rheumatoid arthritis with a DR4/1 peptide. 
  • Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. 
  • Twenty-five year evolution of medical hormonal therapy for prostate cancer. 
  • Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. 
  • Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. 
  • Utility of LHRH antagonists for advanced prostate cancer. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels. 
  • Val-ala-pro-gly, an elastin-derived non-integrin ligand: smooth muscle cell adhesion and specificity. 
  • Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. 
  • Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir. 
  • Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. 
  • [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)] 
  • [GIPC: a new target for therapy in pancreatic adenocarcinoma?] 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8). 
  • d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution. 
  • β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology