Oncogenes

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  Subject Areas on Research

  • A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. 
  • A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A neural survival factor is a candidate oncogene in breast cancer. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A systems biology view of cancer. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. 
  • Age- and sex-specific genomic profiles in non-small cell lung cancer. 
  • Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. 
  • Aggressive fibromatosis. 
  • Aging and neoplasia. 
  • Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells. 
  • An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. 
  • An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • Baculovirus expression of functional P210 BCR-ABL oncogene product. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Biomarkers in the endometrium. 
  • Biomarkers in the ovary. 
  • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. 
  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. 
  • CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping. 
  • Cancer as "rejuvenescence". 
  • Cancer genes disfavoring T cell immunity identified via integrated systems approach. 
  • Cancer's insatiable appetite. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Cellular and molecular studies in brain and nervous system oncology. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Circular ecDNA promotes accessible chromatin and high oncogene expression. 
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. 
  • Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements. 
  • Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. 
  • Current insights on the biology and clinical aspects of VEGF regulation. 
  • Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. 
  • Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation. 
  • Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. 
  • Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity. 
  • Evidence that SOX2 overexpression is oncogenic in the lung. 
  • Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL). 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Family matters: How MYC family oncogenes impact small cell lung cancer. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene therapy and pancreatic cancer. 
  • Gene therapy for lung cancer. 
  • Genetic alterations in prostate adenocarcinoma. 
  • Genetic heterogeneity of diffuse large B-cell lymphoma. 
  • Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. 
  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. 
  • Immortalized hypothalamic gonadotropin-releasing hormone neurons. 
  • Immunity to commensal papillomaviruses protects against skin cancer. 
  • Immunodiagnosis of human malignancy. 
  • Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. 
  • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. 
  • Induction of apoptosis by tumor suppressor genes and oncogenes. 
  • Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. 
  • Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. 
  • Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. 
  • Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. 
  • Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. 
  • Leveling the playing field. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. 
  • Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers. 
  • Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1. 
  • Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia. 
  • Molecular aspects of ovarian cancer. 
  • Molecular basis of endometrial cancer. 
  • Molecular biology of normal development, malignancy and its suppression. 
  • Molecular genetic features of ovarian cancer. 
  • Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. 
  • Molecular genetics: toward an understanding of childhood cancer. 
  • Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. 
  • NIEHS/EPA Workshops. Growth and differentiation factors. 
  • New tumor markers of testis cancer. 
  • Nitric oxide modulation of human leukemia cell differentiation and gene expression. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS. 
  • Oncogene amplification in pediatric brain tumors. 
  • Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. 
  • Oncogenes and anti-oncogenes in human central nervous system tumors. 
  • Oncogenes in ovarian cancer. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. 
  • Oncogenic pathway signatures in human cancers as a guide to targeted therapies. 
  • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. 
  • Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. 
  • PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. 
  • Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context. 
  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. 
  • Pan-cancer analysis of whole genomes. 
  • Pathogenesis of ovarian cancers. 
  • Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. 
  • Phosphatidylinositol kinase type I activity associates with various oncogene products. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype. 
  • Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. 
  • Relationship between gene amplification and chromosomal deviations in malignant human gliomas. 
  • Relationship of cancer and aging. 
  • Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Role of the ABL oncogene tyrosine kinase activity in human leukaemia. 
  • Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. 
  • SFPQ promotes an oncogenic transcriptomic state in melanoma. 
  • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. 
  • Sex differences in oncogenic mutational processes. 
  • Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival. 
  • Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. 
  • Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Suppressing oncogenic transcription with a little healthy competition. 
  • Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. 
  • Template for Reporting Results of Biomarker Testing of Specimens From Patients With Tumors of the Central Nervous System. 
  • The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. 
  • The biology of human lymphoid malignancies revealed by gene expression profiling. 
  • The biology of ovarian cancer. 
  • The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors. 
  • The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. 
  • The genetic attributable risk of breast and ovarian cancer. 
  • The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma. 
  • The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. 
  • The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • The whole-genome landscape of medulloblastoma subtypes. 
  • Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. 
  • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 
  • Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. 
  • Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. 
  • Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. 
  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. 
  • Viruses and oncogenes in brain tumors. 
  • Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. 
  • Wild-type p53: tumors can't stand it. 
  • miR-19 is a key oncogenic component of mir-17-92. 
  • mir-17-92: a polycistronic oncomir with pleiotropic functions. 
  • p53: a two-faced cancer gene. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology