Optic Nerve

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  Subject Areas on Research

  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • A hybrid framework for genome wide epistasis discovery. 
  • A murine model of congenital toxoplasmic retinochoroiditis. 
  • A tridomain model for potassium clearance in optic nerve of Necturus. 
  • ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder. 
  • Acquired bilateral myelinated retinal nerve fibers after unilateral optic nerve sheath fenestration in a child with idiopathic intracranial hypertension. 
  • An unusual presentation of isolated optic nerve sarcoidosis. 
  • Association of Pediatric Choroidal Neovascular Membranes at the Temporal Edge of Optic Nerve and Retinochoroidal Coloboma. 
  • At this junction…. 
  • Automatic detection of pathological myopia using variational level set. 
  • Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model. 
  • Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. 
  • Bilateral Optic Nerve Infiltration in High-Grade Systemic Lymphoma With Secondary Combined Central Retinal Artery and Vein Occlusions. 
  • Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia. 
  • CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • Calcineurin activation causes retinal ganglion cell degeneration. 
  • Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. 
  • Cell death and control of cell survival in the oligodendrocyte lineage. 
  • Cell death in the oligodendrocyte lineage. 
  • Central regulation of photosensitive membrane turnover in the lateral eye of Limulus. I. Octopamine primes the retina for daily transient rhabdom shedding. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Common genetic determinants of intraocular pressure and primary open-angle glaucoma. 
  • Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. 
  • Computed tomography of sarcoidosis of the optic nerve. 
  • Conformal radiation therapy treatment planning reduces the dose to the optic structures for patients with tumors of the paranasal sinuses. 
  • Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy. 
  • Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease. 
  • Correlated size variations in human visual cortex, lateral geniculate nucleus, and optic tract. 
  • Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disk disease. 
  • Delayed radiation necrosis of the optic nerve. 
  • Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. 
  • Design, methods, and conduct of the Optic Neuritis Treatment Trial. 
  • Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning. 
  • Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study. 
  • Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Diagnostic ability of optical coherence tomography with a normative database to detect band atrophy of the optic nerve. 
  • Differences in visual function and optic nerve structure between healthy eyes of blacks and whites. 
  • Diffusion tensor magnetic resonance imaging of the optic nerves in pediatric hydrocephalus. 
  • Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma. 
  • Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography. 
  • Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. 
  • Drusen of the optic disc. A histopathological study. 
  • Drusen of the optic disc. A retrospective study in cadaver eyes. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effects of anemia and hypotension on porcine optic nerve blood flow and oxygen delivery. 
  • Effects of hypothermia on the in vivo measurement of rapid axonal transport in the rat: a cautionary note. 
  • Effects of p-xylene inhalation on axonal transport in the rat retinal ganglion cells. 
  • Evaluation of optic nerve development in preterm and term infants using handheld spectral-domain optical coherence tomography. 
  • Fast acquisition and reconstruction of optical coherence tomography images via sparse representation. 
  • Formation of Macular Inner Nuclear Layer Cysts in Optic Atrophy. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. 
  • Giant cell arteritis mimicking infiltrative leptomeningeal disease of the optic nerves. 
  • Glaucoma care and conformance with preferred practice patterns. Examination of the private, community-based ophthalmologist. 
  • Glaucoma, apoptosis, and neuroprotection. 
  • HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS. 
  • Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. 
  • Idiopathic intracranial hypertension: a case report with optic nerve histopathology. 
  • Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat. 
  • Impact of Different Visual Field Testing Paradigms on Sample Size Requirements for Glaucoma Clinical Trials. 
  • In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure. 
  • Increased spontaneous unit activity and appearance of spontaneous negative potentials in the goldfish tectum during refinement of the optic projection. 
  • Influence of OCT signal strength on macular, optic nerve head, and retinal nerve fiber layer parameters. 
  • Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach. 
  • Kv3.1b is a novel component of CNS nodes. 
  • Macrophage infiltration in the human retina. 
  • Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects. 
  • Macular and nerve fiber layer thickness in amblyopia: the Sydney Childhood Eye Study. 
  • Magnetic resonance imaging of juxtapapillary plaques in cadaver eyes. 
  • Magnetic resonance imaging of optic gliomas. 
  • Measuring Optic Nerve Sheath Diameter as a Proxy for Intracranial Pressure. 
  • Medical backgrounders: glaucoma. 
  • Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. 
  • Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. 
  • Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones. 
  • Morphometric assessment of the central retinal artery and vein in the optic nerve head. 
  • N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration. 
  • Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma. 
  • Nogo receptor 1 is expressed by nearly all retinal ganglion cells. 
  • Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve. 
  • Observations on the effect of hypotonic solutions on the myelin sheath in the central nervous system. 
  • Ocular toxicity following high dose chemotherapy and autologous transplant. 
  • Ocular toxoplasmosis presenting with focal retinal nerve fiber atrophy simulating glaucoma. 
  • Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB-Mediated Autoinflammatory Disease with Retinal Dystrophy. 
  • Optic chiasm, optic nerve, and retinal involvement secondary to varicella-zoster virus. 
  • Optic nerve sheath decompression for progressive central retinal vein occlusion. 
  • Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading. 
  • Optic neuritis in Singapore. 
  • Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. 
  • Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association. 
  • Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation. 
  • Parallels in the visual afferent projections of the thalamus in the hedgehog (Paraechinus hypomelas) and the turtle (Pseudemys scripta). 
  • Pediatric optic nerve sheath decompression. 
  • Perioperative estimation of the intracranial pressure using the optic nerve sheath diameter during liver transplantation. 
  • Phosphorylated microtubule associated protein (MAP1B-Phos) in the retina during regeneration of the fish optic nerve. 
  • Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing. 
  • Point-of-Care Ultrasound Abnormalities in Late-Onset Severe Preeclampsia: Prevalence and Association With Serum Albumin and Brain Natriuretic Peptide. 
  • Posterior axial corneal malformation and uveoretinal angiodysgenesis--a neurocristopathy? 
  • Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. 
  • Posttraumatic venous obstructive retinopathy associated with enlarged optic nerve sheath. 
  • Predisciform senile macular degeneration. 
  • Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. 
  • Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. 
  • Racemose (cirsoid) hemangioma in rhesus monkey retina. 
  • Radial optic neurotomy as treatment for central retinal vein occlusion. 
  • Radial optic neurotomy as treatment for central retinal vein occlusion. 
  • Radial optic neurotomy in retinal vein occlusion. 
  • Radial optic neurotomy in the porcine eye without retinal vein occlusion. 
  • Radiation dose-volume effects of optic nerves and chiasm. 
  • Recurrence of astrocytoma of optic nerve after 48 years. 
  • Retinal Imaging of Infants on Spectral Domain Optical Coherence Tomography. 
  • Retinal ganglion cells and axons survive optic nerve transection. 
  • Retinal nerve fibre layer thickness measurements in patients using chloroquine. 
  • Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia. 
  • Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. 
  • Seesaw nystagmus following whole brain irradiation and intrathecal methotrexate. 
  • Silicone and blindness: computed tomography imaging. 
  • Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways. 
  • Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. 
  • Spontaneous retinal activity is tonic and does not drive tectal activity during activity-dependent refinement in regeneration. 
  • Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes. 
  • Subacute vision loss in a young, obese female. 
  • Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue. 
  • Swelling Superimposed on Atrophy Masks Optic Nerve Pathology. 
  • The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. 
  • The etiology and treatment of macular detachment associated with optic nerve pits and related anomalies. 
  • The isolated perfused frog eye: a useful preparation for the investigation of drug effects on retinal function. 
  • The normal organization of the lateral posterior nucleus in the golden hamster and its reorganization after neonatal superior colliculus lesions. 
  • The organization of afferents to the lateral posterior nucleus in the golden hamster after different combinations of neonatal lesions. 
  • The organization of the lateral posterior nucleus in neonatal golden hamsters. 
  • The phosphorylated isoform of microtubule associated protein 1B (MAP1B) is expressed in the visual system of the tench (Tinca tinca, L) during optic nerve regeneration. 
  • Thrombolytic Therapy for Acute Central Retinal Artery Occlusion. 
  • Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. 
  • Unexpected autopsy findings arising from postmortem ocular examination. 
  • Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics