Optic Nerve Diseases

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  Subject Areas on Research

  • "Other" neurologic complications after cardiac surgery. 
  • 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. 
  • A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population: The EPIC-Norfolk Eye Study. 
  • A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss From Optic Disc Photographs. 
  • A case of nodular fasciitis causing compressive optic neuropathy. 
  • A combined index of structure and function for staging glaucomatous damage. 
  • A comparison of cup-to-disc ratio estimates by fundus biomicroscopy and stereoscopic optic disc photography in the Tema Eye Survey. 
  • A comparison of the Marcus Gunn and alternating light tests for afferent pupillary defects. 
  • A hybrid framework for genome wide epistasis discovery. 
  • Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema. 
  • Acquired bilateral myelinated retinal nerve fibers after unilateral optic nerve sheath fenestration in a child with idiopathic intracranial hypertension. 
  • Acute visual loss and other disorders of the eyes. 
  • African Descent and Glaucoma Evaluation Study (ADAGES): II. Ancestry differences in optic disc, retinal nerve fiber layer, and macular structure in healthy subjects. 
  • African Descent and Glaucoma Evaluation Study (ADAGES): III. Ancestry differences in visual function in healthy eyes. 
  • Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population. 
  • Agreement among 3 optical imaging methods for the assessment of optic disc topography. 
  • Agreement between stereophotographic and confocal scanning laser ophthalmoscopy measurements of cup/disc ratio: effect on a predictive model for glaucoma development. 
  • Agreement for detecting glaucoma progression with the GDx guided progression analysis, automated perimetry, and optic disc photography. 
  • American Chinese glaucoma imaging study: a comparison of the optic disc and retinal nerve fiber layer in detecting glaucomatous damage. 
  • An objective structural and functional reference standard in glaucoma. 
  • An unusual presentation of isolated optic nerve sarcoidosis. 
  • Artifacts in spectral-domain optical coherence tomography measurements in glaucoma. 
  • Artificial neural network-based glaucoma diagnosis using retinal nerve fiber layer analysis. 
  • Atypical lymphocytic angiitis of the optic nerve and central nervous system. 
  • Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss. 
  • Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects. 
  • Baseline visual field characteristics in the ocular hypertension treatment study. 
  • Bayesian machine learning classifiers for combining structural and functional measurements to classify healthy and glaucomatous eyes. 
  • Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss. 
  • Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study. 
  • Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. 
  • CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. 
  • Can an inexperienced observer accurately plot disc contours using Heidelberg retinal Tomograph? 
  • Carboplatin treatment of progressive optic pathway gliomas to delay radiotherapy. 
  • Characteristics and appearance of the normal optic nerve head in 6-year-old children. 
  • Characterization of Artifacts Associated With Multicolor Confocal Scanning Laser Ophthalmoscopy. 
  • Chiasmal syndrome due to intrasellar abscess. 
  • Clarifying the role of ATOH7 in glaucoma endophenotypes. 
  • Clinical characteristics in 53 patients with cat scratch optic neuropathy. 
  • Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. 
  • Clinicians agreement in establishing glaucomatous progression using the Heidelberg retina tomograph. 
  • Combining structural and functional testing for detection of glaucoma. 
  • Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments. 
  • Comparing stereometric parameters between Heidelberg Retinal Tomography 2 and 3 in Asian eyes: the Singapore Malay Eye Study. 
  • Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. 
  • Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma. 
  • Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. 
  • Comparison of retinal nerve fiber layer and optic disc imaging for diagnosing glaucoma in patients suspected of having the disease. 
  • Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters. 
  • Comparison of scanning laser polarimetry using variable corneal compensation and retinal nerve fiber layer photography for detection of glaucoma. 
  • Computed tomography of sarcoidosis of the optic nerve. 
  • Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes. 
  • Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure. 
  • Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy. 
  • Correlation among retinal thickness, optic disc, and visual field in glaucoma patients and suspects: a pilot study. 
  • Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment. 
  • Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disk disease. 
  • Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss. 
  • Detecting Structural Progression in Glaucoma with Optical Coherence Tomography. 
  • Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning. 
  • Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation. 
  • Detection of progressive retinal nerve fiber layer thickness loss with optical coherence tomography using 4 criteria for functional progression. 
  • Determinants of agreement between the confocal scanning laser tomograph and standardized assessment of glaucomatous progression. 
  • Determinants of image quality of Heidelberg Retina Tomography II and its association with optic disc parameters in a population-based setting. 
  • Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study. 
  • Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES). 
  • Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography. 
  • Diagnosis of glaucoma and detection of glaucoma progression using spectral domain optical coherence tomography. 
  • Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection. 
  • Diagnostic ability of Heidelberg Retina Tomography in detecting glaucoma in a population setting: the Singapore Malay Eye Study. 
  • Diagnostic accuracy of the Heidelberg Retina Tomograph for glaucoma a population-based assessment. 
  • Diagnostic accuracy of the Matrix 24-2 and original N-30 frequency-doubling technology tests compared with standard automated perimetry. 
  • Diffuse glaucomatous structural and functional damage in the hemifield without significant pattern loss. 
  • Drusen of the optic disc. 
  • Drusen of the optic disc. A histopathological study. 
  • Drusen of the optic disc. A retrospective study in cadaver eyes. 
  • Effect of disease severity and optic disc size on diagnostic accuracy of RTVue spectral domain optical coherence tomograph in glaucoma. 
  • Efficient optic cup detection from intra-image learning with retinal structure priors. 
  • Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma. 
  • Eleven cases of sarcoidosis of the optic nerve. 
  • Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies. 
  • Estimated rates of retinal ganglion cell loss in glaucomatous eyes with and without optic disc hemorrhages. 
  • Estimating Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects. 
  • Estimating the rate of retinal ganglion cell loss in glaucoma. 
  • Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population. 
  • Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma. 
  • Fourier analysis of scanning laser polarimetry measurements with variable corneal compensation in glaucoma. 
  • Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study. 
  • Frequency of Testing to Detect Visual Field Progression Derived Using a Longitudinal Cohort of Glaucoma Patients. 
  • From Machine to Machine: An OCT-Trained Deep Learning Algorithm for Objective Quantification of Glaucomatous Damage in Fundus Photographs. 
  • Glaucomatous optic neuropathy evaluation project: a standardized internet system for assessing skills in optic disc examination. 
  • Gliomatosis cerebri presenting with optic nerve involvement: MRI. 
  • Gln368STOP myocilin mutation in families with late-onset primary open-angle glaucoma. 
  • Gray Optic Disc Crescent: Evaluation of Anatomic Correlate by Spectral-Domain OCT. 
  • Headaches, rapidly progressive visual loss, and bilateral disc edema. 
  • Human Versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs. 
  • Identifying glaucomatous vision loss with visual-function-specific perimetry in the diagnostic innovations in glaucoma study. 
  • Idiopathic intracranial hypertension: a case report with optic nerve histopathology. 
  • Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning. 
  • Impact of atypical retardation patterns on detection of glaucoma progression using the GDx with variable corneal compensation. 
  • Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians. 
  • Inconsistency of the published definition of ocular hypertension. 
  • Incorporating risk factors to improve the assessment of rates of glaucomatous progression. 
  • Infections and glaucoma. 
  • Influence of disease severity and optic disc size on the diagnostic performance of imaging instruments in glaucoma. 
  • Influence of refractive error on optic disc topographic parameters: the singapore malay eye study. 
  • Integrating event- and trend-based analyses to improve detection of glaucomatous visual field progression. 
  • Intereye spatial relationship of abnormal neuroretinal rim locations in glaucoma patients from the diagnostic innovations in glaucoma study. 
  • Intracranial metastatic adenocarcinoma of the prostate presenting as visual disturbance. 
  • Intracranial optic nerve enlargement in infantile Krabbe disease. 
  • Intravitreal triamcinolone acetonide for acute radiation papillopathy. 
  • Iron homeostasis and eye disease. 
  • Is scanning laser polarimetry ready for clinical practice? 
  • Likelihood ratios for glaucoma diagnosis using spectral-domain optical coherence tomography. 
  • Long-term intraocular pressure fluctuations and risk of conversion from ocular hypertension to glaucoma. 
  • Long-term variability of GDx VCC retinal nerve fiber layer thickness measurements. 
  • Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography. 
  • Magnetic Resonance Imaging Abnormalities of the Optic Nerve Sheath and Intracranial Internal Carotid Artery in Giant Cell Arteritis. 
  • Management of suprachoroidal hemorrhage. 
  • Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology. 
  • Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies. 
  • Mouse models of retinal ganglion cell death and glaucoma. 
  • Multi-trait genome-wide association study identifies new loci associated with optic disc parameters. 
  • Myopic Maculopathy and Optic Disc Changes in Highly Myopic Young Asian Eyes and Impact on Visual Acuity. 
  • Ocular conditions associated with peripapillary subretinal neovascularization, their relative frequencies, and associated outcomes. 
  • Ocular involvement in congenital leukemia. 
  • Optic chiasm, optic nerve, and retinal involvement secondary to varicella-zoster virus. 
  • Optic disc melanocytoma and glaucoma. 
  • Optic nerve compression in infantile malignant autosomal recessive osteopetrosis. 
  • Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain. 
  • Pathologic changes in highly myopic eyes of young males in Singapore. 
  • Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes. 
  • Performance of the Moorfields motion displacement test for identifying eyes with glaucoma. 
  • Periocular corticosteroids in diabetic papillopathy. 
  • Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: Methods and Screening Results. 
  • Positional independence of optic nerve head and retinal nerve fiber layer thickness measurements with spectral-domain optical coherence tomography. 
  • Prediction of functional loss in glaucoma from progressive optic disc damage. 
  • Primary optic nerve meningiomas in F344 rats. 
  • Progression of patterns (POP): a machine classifier algorithm to identify glaucoma progression in visual fields. 
  • Progressive normal-tension Glaucoma. 
  • Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency. 
  • Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes. 
  • Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods. 
  • Rates of progressive retinal nerve fiber layer loss in glaucoma measured by scanning laser polarimetry. 
  • Rats! Hyperglycemia protects against glaucoma! 
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells. 
  • Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients. 
  • Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula. 
  • Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements. 
  • Relationship of SITA and full-threshold standard perimetry to frequency-doubling technology perimetry in glaucoma. 
  • Relationship of central corneal thickness with optic disc parameters: the Singapore Malay Eye Study. 
  • Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. 
  • Relationship of retinal vascular tortuosity with the neuroretinal rim: the singapore malay eye study. 
  • Relationship of the 24-hour pattern of intraocular pressure with optic disc appearance in primary open-angle glaucoma. 
  • Relevance vector machine and support vector machine classifier analysis of scanning laser polarimetry retinal nerve fiber layer measurements. 
  • Reliability of brightness comparison testing in predicting afferent pupillary defects. 
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  • Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements. 
  • Reproducibility of visual field end point criteria for standard automated perimetry, full-threshold, and Swedish interactive thresholding algorithm strategies: diagnostic innovations in glaucoma study. 
  • Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc. 
  • Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression. 
  • Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma. 
  • Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss. 
  • Retinal nerve fiber layer thickness measurements: uveitis, a major confounding factor. 
  • Retinal vascular caliber between eyes with asymmetric glaucoma. 
  • Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study. 
  • Retinopathy and optic neuropathy after transplantation. 
  • Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. 
  • Reversal of Cupping in an Infant, Shown by Optical Coherence Tomography. 
  • Reversal of retinal ganglion cell dysfunction after surgical reduction of intraocular pressure. 
  • Short-wavelength automated perimetry can predict glaucomatous standard visual field loss by ten years. 
  • Structure-function relationship in glaucoma using spectral-domain optical coherence tomography. 
  • Successful management of orbital cellulitis and temporary visual loss after blepharoplasty. 
  • The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data. 
  • The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects. 
  • The Effect of Age on Increasing Susceptibility to Retinal Nerve Fiber Layer Loss in Glaucoma. 
  • The Ocular Hypertension Treatment Study: design and baseline description of the participants. 
  • The Ocular Hypertension Treatment Study: reproducibility of cup/disk ratio measurements over time at an optic disc reading center. 
  • The Relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma. 
  • The case of the gray optic disc! 
  • The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma. 
  • The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation. 
  • The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg Retina Tomograph Glaucoma Probability Score. 
  • The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral-domain optical coherence tomography. 
  • The effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma. 
  • The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation. 
  • The rate of structural change: the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study. 
  • The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells. 
  • The relationship between intraocular pressure reduction and rates of progressive visual field loss in eyes with optic disc hemorrhage. 
  • The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change. 
  • Three-dimensional nature of retinal nerve fiber layer defects. 
  • Unanticipated vision loss after pars plana vitrectomy. 
  • Unexpected autopsy findings arising from postmortem ocular examination. 
  • Unilateral optic neuropathy following vincristine chemotherapy. 
  • Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields. 
  • Use of intraocular video endoscopic examination in the preoperative evaluation of keratoprosthesis surgery to assess visual potential. 
  • Use of progressive glaucomatous optic disk change as the reference standard for evaluation of diagnostic tests in glaucoma. 
  • Validity of a new optic disc grading software for use in clinical and epidemiological research. 
  • Visual Crowding in Glaucoma. 
  • Visual field progression. 
  • Wavelength independence and interdevice variability of optical coherence tomography. 
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  Keywords of People

  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics