Organ Specificity

• 

  Subject Areas on Research

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces organ- specific differential gene expression in male Japanese medaka (Oryzias latipes). 
  • A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells. 
  • A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. 
  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. 
  • A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. 
  • A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. 
  • A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A distal enhancer and an ultraconserved exon are derived from a novel retroposon. 
  • A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. 
  • A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function. 
  • A kinetic study of embryonic cell adhesion. 
  • A multimodal cell census and atlas of the mammalian primary motor cortex. 
  • A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. 
  • A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. 
  • A pipeline to determine RT-PCR control genes for evolutionary studies: application to primate gene expression across multiple tissues 
  • A recombination-based assay demonstrates that the fragile X sequence is transcribed widely during development. 
  • A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans. 
  • A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex. 
  • AAEE minimonograph #25: Single-fiber electromyography in myasthenia gravis. 
  • ATM activation in normal human tissues and testicular cancer. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. 
  • Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. 
  • Airway-specific inducible transgene expression using aerosolized doxycycline. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Allotransplantation of insulinoma into the testis of diabetic rats. 
  • An active role for basement membrane assembly and modification in tissue sculpting. 
  • An antibody to human thymic Hassall's body epithelium recognizes a subset of blood group A antigens. 
  • An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 
  • Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. 
  • Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Applications of a rat multiple tissue gene expression data set. 
  • Architecture of the human regulatory network derived from ENCODE data. 
  • Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. 
  • Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. 
  • Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. 
  • Autopsy findings in late-onset Pompe disease: a case report and systematic review of the literature. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Beta-adrenergic receptor kinase: primary structure delineates a multigene family. 
  • Biochemical and immunological properties of dog brain isorenin. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • Bombesin-like peptide mediates lung injury in a baboon model of bronchopulmonary dysplasia. 
  • Brain-specific polyA- transcripts are detected in polyA+ RNA: do complex polyA- brain RNAs really exist? 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Capturing the primordial Kras mutation initiating urethane carcinogenesis. 
  • Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. 
  • Catecholaminergic innervation of the hippocampus in the cynomolgus monkey. 
  • Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell-specific constraints to the lateral diffusion of a membrane glycoprotein. 
  • Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. 
  • Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of human CD7 transgenic mice. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Clinical aspects of MuSK antibody positive seronegative MG. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Cloning and developmental expression of the chick type II and type III TGF beta receptors. 
  • Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. 
  • Cloning, expression, and cellular localization of a human prenylcysteine lyase. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. 
  • Comparative cellular analysis of motor cortex in human, marmoset and mouse. 
  • Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. 
  • Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Conservation and diversification of SCARECROW in maize. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016. 
  • Contact focusing multimodal microprobes for ultraprecise laser tissue surgery. 
  • Cooperation and functional diversification of two closely related galactolipase genes for jasmonate biosynthesis. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Copper-chelatin: isolation from various eucaryotic sources. 
  • Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. 
  • DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • Degradation of spectrin and ankyrin in the ischemic rat kidney. 
  • Determining organ dose: the holy grail. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation. 
  • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. 
  • Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. 
  • Differential expression of VEGF isoforms in mouse during development and in the adult. 
  • Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differential screening of a subtracted cDNA library: a method to search for genes preferentially expressed in multiple tissues. 
  • Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. 
  • Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy. 
  • Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. 
  • Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. 
  • Distribution of proteasomes and of the five proteolytic activities in rat tissues. 
  • Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. 
  • Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. 
  • Downregulation of a unique photoreceptor protein correlates with improper outer segment assembly. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. 
  • EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. 
  • Ecology drives a global network of gene exchange connecting the human microbiome. 
  • Editorial: Selectivity in beta-adrenergic responses: clinical implications. 
  • Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats. 
  • Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats. 
  • Effect of maternal ethanol ingestion on neonatal rat brain and heart ornithine decarboxylase. 
  • Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses. 
  • Effects of premature termination codon polymorphisms in the Drosophila pseudoobscura subclade. 
  • Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. 
  • Elastic image mapping for 4-D dose estimation in thoracic radiotherapy. 
  • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. 
  • Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity. 
  • Equations for predicting diver regional skin temperatures as a function of mean skin temperature. 
  • Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. 
  • Estimation of tissue resistivities from multiple-electrode impedance measurements. 
  • Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent. 
  • Exploiting expression patterns across multiple tissues to map expression quantitative trait loci. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract. 
  • Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. 
  • Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences. 
  • From breast to the brain: unraveling the puzzle of metastasis organotropism. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Further defining housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues". 
  • Galphaq-dependent signaling cascades stimulate water-seeking behavior. 
  • Gene expression and adaptive noncoding changes during human evolution. 
  • Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. 
  • Gene therapy for glycogen storage diseases. 
  • Generation of a Magoh conditional allele in mice. 
  • Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. 
  • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. 
  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide identification and predictive modeling of tissue-specific alternative polyadenylation. 
  • Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). 
  • Genome-wide survey and expression analysis of the OSCA gene family in rice. 
  • Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • Gz, a guanine nucleotide-binding protein with unique biochemical properties. 
  • High-Throughput Tissue Bioenergetics Analysis Reveals Identical Metabolic Allometric Scaling for Teleost Hearts and Whole Organisms. 
  • High-resolution experimental and computational profiling of tissue-specific known and novel miRNAs in Arabidopsis. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Hormonal control of oviduct growth and differentiation. 
  • Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. 
  • Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants. 
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. 
  • Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. 
  • Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma. 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. 
  • Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. 
  • Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene. 
  • Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. 
  • Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunological and Pathological Landscape of Dengue Serotypes 1-4 Infections in Immune-Competent Mice. 
  • Immunometabolism: From basic mechanisms to translation. 
  • Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. 
  • Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation. 
  • Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. 
  • In vivo magnetic resonance imaging of the blue crab, Callinectes sapidus: effect of cadmium accumulation in tissues on proton relaxation properties. 
  • Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice. 
  • Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. 
  • Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition. 
  • Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation. 
  • Intensity-modulated radiotherapy optimization with gEUD-guided dose-volume objectives. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. 
  • Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity. 
  • Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription. 
  • Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Isolation and nucleotide sequence of human liver glycogen debranching enzyme mRNA: identification of multiple tissue-specific isoforms. 
  • Isorenin in dog brain and other tissues. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers. 
  • Leukocyte migration is regulated by L-selectin endoproteolytic release. 
  • Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Mapping eQTL by leveraging multiple tissues and DNA methylation. 
  • Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. 
  • Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. 
  • Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia. 
  • Mechanism of action of angiotensin-converting enzyme (ACE) inhibitors in hypertension and heart failure. Role of plasma versus tissue ACE. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. Relations to the mode of activation by hormones. 
  • Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. 
  • Metastatic prostate cancer in a transgenic mouse. 
  • Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. 
  • Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape. 
  • Migration of human dendritic cells after injection in patients with metastatic malignancies. 
  • Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. 
  • Mitochondrial biogenesis in striated muscles: rapid induction of citrate synthase mRNA by nerve stimulation. 
  • Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. 
  • Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. 
  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. 
  • Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. 
  • Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. 
  • Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Mouse model of glycogen storage disease type III. 
  • Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. 
  • Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. 
  • Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4. 
  • Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. 
  • Murine CD7 shares antigenic cross-reactivity with HSP-60. 
  • Mutational fingerprints of aging. 
  • Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene. 
  • Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. 
  • Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy. 
  • Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. 
  • Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat. 
  • Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. 
  • Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. 
  • New tools for studying microglia in the mouse and human CNS. 
  • Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Observations on the effect of hypotonic solutions on the myelin sheath in the central nervous system. 
  • Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. 
  • Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues. 
  • Organ-specific radiation dose rates and effective dose rates during percutaneous nephrolithotomy. 
  • Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. 
  • P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. 
  • PET/CT mediastinal and liver FDG uptake: effects of biological and procedural factors. 
  • PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. 
  • Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. 
  • Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. 
  • Perinatal dietary supplementation with a soy lecithin preparation: effects on development of central catecholaminergic neurotransmitter systems. 
  • Pharmacologic manipulation of ob expression in a dietary model of obesity. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Placental transfer of metals of coal fly ash into various fetal organs of rat. 
  • Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. 
  • Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. 
  • Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. 
  • Potential role of omega-3-derived resolution mediators in metabolic inflammation. 
  • Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Predicting the sites of metastases from lung cancer using molecular biologic markers. 
  • Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. 
  • Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. 
  • Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. 
  • Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL. 
  • Pros and cons of organ shielding for CT imaging. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Quantification of prostate and seminal vesicle interfraction variation during IMRT. 
  • Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis. 
  • Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values. 
  • Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes. 
  • R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. 
  • RCA2: a scalable supervised clustering algorithm that reduces batch effects in scRNA-seq data. 
  • Radiotoxicity of systemically administered 211At-labeled human/mouse chimeric monoclonal antibody: a long-term survival study with histologic analysis. 
  • Realistic reference adult and paediatric phantom series for internal and external dosimetry. 
  • Receptor binding sites for atrial natriuretic factor are expressed by brown adipose tissue. 
  • Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. 
  • Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle. 
  • Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome. 
  • Regional cerebral blood flow in normal blood circulated and perfluorocarbon transfused rats. 
  • Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. 
  • Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of expression of transcobalamin II receptor in the rat. 
  • Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. 
  • Regulatory elements governing transcription in specialized myofiber subtypes. 
  • Renal and hepatic lysosomal catabolism of luteinizing hormone. 
  • Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. 
  • Repetitive transcranial magnetic stimulation activates specific regions in rat brain. 
  • Respiration triggered magnetic drug targeting in the lungs. 
  • Restoration of p53 function leads to tumour regression in vivo. 
  • Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning. 
  • Retina-specifically expressed novel subtypes of bovine cyclophilin. 
  • Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. 
  • Selection and validation of endogenous reference genes using a high throughput approach. 
  • Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox. 
  • Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. 
  • Serious toxicity associated with annular microwave array induction of whole-body hyperthermia in normal dogs. 
  • Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. 
  • Site-specific retinoic acid production in the brain of adult songbirds. 
  • Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. 
  • Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. 
  • Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. 
  • Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets. 
  • Staging non-small cell carcinoma of the lung using technetium-99m-labeled monoclonal antibodies. 
  • Statin intolerance in a referral lipid clinic. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. 
  • Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex. 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility. 
  • Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers. 
  • The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. 
  • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Populus holobiont: dissecting the effects of plant niches and genotype on the microbiome. 
  • The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. 
  • The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The gene encoding vitamin K-dependent anticoagulant protein S is expressed in multiple rabbit organs as demonstrated by northern blotting, in situ hybridization, and immunohistochemistry. 
  • The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. 
  • The human plasminogen activator inhibitor type I gene promoter targets to kidney. 
  • The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. 
  • The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. 
  • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. 
  • The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. 
  • The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. 
  • The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. 
  • The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. 
  • The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. 
  • The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells. 
  • The triple threat of cryptococcosis: it's the body site, the strain, and/or the host. 
  • The unique identity of rat hepatoma phenylalanine hydroxylase. 
  • The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia. 
  • Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. 
  • Tissue distribution and thyroid hormone effects on mRNA abundance for membrane transporters Mct8, Mct10, and organic anion-transporting polypeptides (Oatps) in a teleost fish. 
  • Tissue factor in brain is not saturated with factor VIIa: implications for factor VIIa dosing in intracerebral hemorrhage. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. 
  • Tissue-specific expression of kallikrein-related genes in the rat. 
  • Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development. 
  • Tissue-specific expression of the mammalian bombesin gene. 
  • Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice. 
  • Tissue-specific genetic control of splicing: implications for the study of complex traits. 
  • Tissue-specific inactivation of murine M6P/IGF2R. 
  • Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. 
  • Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Turnover rates of amino acid neurotransmitters in regions of rat cerebellum. 
  • Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. 
  • Use of recombinant adenovirus for metabolic engineering of mammalian cells. 
  • Use of the lesion model for examining toxicant effects on cognitive behavior. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. 
  • Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus. 
  • VirtualDose: a software for reporting organ doses from CT for adult and pediatric patients. 
  • Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. 
  • Wilms' tumor suppressor gene expression in rat and human mesothelioma. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • [Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • mir-17-92: a polycistronic oncomir with pleiotropic functions. 
  • p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology