Organophosphorus Compounds

• 

  Subject Areas on Research

  • A study of the binding of thiamine diphosphate and thiochrome diphosphate to the pyruvate dehydrogenase multienzyme complex. 
  • ALSUntangled No. 29: MitoQ. 
  • An in vitro comparison of rat and chicken brain neurotoxic esterase. 
  • Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry. 
  • Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. 
  • Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels. 
  • Biochemical and morphological validation of a rodent model of organophosphorus-induced delayed neuropathy. 
  • Biochemical and neuropathological assessment of triphenyl phosphite in rats. 
  • Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG. 
  • Boranophosphate nucleic acids--a versatile DNA backbone. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • Cardiovascular disease risk stratification with stress single-photon emission computed tomography technetium-99m tetrofosmin imaging in patients with the metabolic syndrome and diabetes mellitus. 
  • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. 
  • Chromatographic characterization of neurotoxic esterase. 
  • Common mechanism of toxicity: a case study of organophosphorus pesticides. 
  • Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. 
  • Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. 
  • Complete remission seven years after treatment for metastatic malignant melanoma. 
  • Crystal structure of the transcription activator BmrR bound to DNA and a drug. 
  • Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort. 
  • Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. 
  • Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. 
  • Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model. 
  • Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. 
  • Detection of organophosphate flame retardants in furniture foam and U.S. house dust. 
  • Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. 
  • Differentiation and classification of RNA motifs using small molecule-based pattern recognition. 
  • Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus. 
  • Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure. 
  • Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain. 
  • Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex. 
  • Effects of organophosphates on the visual system of rats. 
  • Efficiency comparison between 99m Tc-tetrofosmin and 99m Tc-sestamibi myocardial perfusion studies. 
  • Epithelioid Hyalinizing Sarcoma With MGA-NUTM1 Fusion. 
  • Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. 
  • Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. 
  • Exposures, mechanisms, and impacts of endocrine-active flame retardants. 
  • Flame retardant associations between children's handwipes and house dust. 
  • Fluorescent derivatives of the pyruvate dehydrogenase component of the Escherichia coli pyruvate dehydrogenase complex. 
  • Fotemustine (S 10036) in the intra-arterial treatment of liver metastasis from malignant melanoma. A phase II Study. 
  • Fotemustine, dacarbazine, vindesine combination chemotherapy in advanced malignant melanoma: a phase II study of 43 patients. 
  • Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young. 
  • GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. 
  • GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo. 
  • Gated 99mTc-tetrofosmin and 18F-FDG studies: a comparison of single-acquisition and separate-acquisition protocols. 
  • Gating provides improved accuracy for differentiating artifacts from true lesions in equivocal fixed defects on technetium 99m tetrofosmin perfusion SPECT. 
  • Glutamate as transmitter of hippocampal perforant path. 
  • Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. 
  • HIV pre-exposure prophylaxis. 
  • High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. 
  • In vitro synthesis of molybdopterin from precursor Z using purified converting factor. Role of protein-bound sulfur in formation of the dithiolene. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Induced plant defense responses against chewing insects. Ethylene signaling reduces resistance of Arabidopsis against Egyptian cotton worm but not diamondback moth. 
  • Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. 
  • Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates. 
  • Internally administered isotopes in the treatment of solid malignancy. 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis. 
  • Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai. 
  • Mammotomography with pinhole incomplete circular orbit SPECT. 
  • Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations. 
  • Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. 
  • Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. 
  • Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. 
  • Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. 
  • Monitoring indoor exposure to organophosphate flame retardants: hand wipes and house dust. 
  • Murine susceptibility to organophosphorus-induced delayed neuropathy (OPIDN). 
  • Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial. 
  • Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. 
  • Newer treatments for HIV in children. 
  • Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. 
  • Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). 
  • Outcome prediction in patients at high risk for coronary artery disease: comparison between 99mTc tetrofosmin and 99mTc sestamibi. 
  • Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure. 
  • Phenylmethylsulfonyl fluoride alters sensitivity to organophosphorus-induced delayed neurotoxicity in developing animals. 
  • Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. 
  • Phosphorus-based SAHA analogues as histone deacetylase inhibitors. 
  • Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate. 
  • Prediction of mortality in patients with coronary artery disease undergoing vasodilator stress testing: a comparison between 99mTc-tetrofosmin and 99mTc-sestamibi. 
  • Preliminary Clinical and Molecular Analysis Results From a Single-Arm Phase 2 Trial of Brigatinib in Patients With Disease Progression After Next-Generation ALK Tyrosine Kinase Inhibitors in Advanced ALK+ NSCLC. 
  • Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis. 
  • Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study. 
  • Prenatal organophosphorus pesticide exposure and executive function in preschool-aged children in the Norwegian Mother, Father and Child Cohort Study (MoBa). 
  • Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients. 
  • Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride. 
  • Radical Breakthroughs in Natural Product and Cofactor Biosynthesis. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Regulatory and research issues related to cholinesterase inhibition. 
  • Relationship of neuropathy target esterase inhibition to neuropathology and ataxia in hens given organophosphorus esters. 
  • Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial. 
  • Safety and Immunogenicity of a Randomized Phase 1 Prime-Boost Trial With ALVAC-HIV (vCP205) and Oligomeric Glycoprotein 160 From HIV-1 Strains MN and LAI-2 Adjuvanted in Alum or Polyphosphazene. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. 
  • Structural characterization of a molybdopterin precursor. 
  • Structural mapping of aspartate transcarbamoylase by fluorescence energy-transfer measurements: determination of the distance between catalytic sites of different subunits. 
  • Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. 
  • Surface-enhanced Raman spectrometry of organophosphorus chemical agents. 
  • The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo. 
  • The organophosphate insecticide diazinon and aging: Neurobehavioral and mitochondrial effects in zebrafish exposed as embryos or during aging. 
  • The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. 
  • The role of neurotoxic esterase (NTE) in the prevention and potentiation of organophosphorus-induced delayed neurotoxicity (OPIDN). 
  • Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. 
  • Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine. 
  • Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Triphenyl phosphite: in vivo and in vitro inhibition of rat neurotoxic esterase. 
  • Tris(1,3-dichloro-2-propyl)phosphate Induces Genome-Wide Hypomethylation within Early Zebrafish Embryos. 
  • Urinary biomarkers of flame retardant exposure among collegiate U.S. gymnasts. 
  • Urinary metabolites of organophosphate flame retardants and their variability in pregnant women. 
  • Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. 
  • Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. 
• 

  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology