Osteoblasts

• 

  Subject Areas on Research

  • A bioactive titanium foam scaffold for bone repair. 
  • A comparative histologic study of rapid three-dimensional zygomatic suture expansion osteogenesis. 
  • A quantitative histologic study of avian osteopetrotic bone demonstrating normal osteoclast numbers and increased osteoblastic activity. 
  • A quantitative histomorphometric comparison of 40 micron thick Paragon sections with 5 micron thick Goldner sections in the study of undecalcified bone. 
  • APPOSITIONAL BONE FORMATION IN CANINE BONE: A QUANTITATIVE MICROSCOPIC STUDY USING TETRACYCLINE MARKERS. 
  • Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. 
  • Alteration in osteoblast activity and nutritional vitamin-D deficiency in non-hypercalcemic malignancy. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis. 
  • Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. 
  • Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts' coupling to osteoblasts. 
  • Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro. 
  • Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling. 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Cellular response to phase-separated blends of tyrosine-derived polycarbonates. 
  • Change in surface roughness by dynamic shape-memory acrylate networks enhances osteoblast differentiation. 
  • Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Concentration-Dependent hMSC Differentiation on Orthogonal Concentration Gradients of GRGDS and BMP-2 Peptides. 
  • Control of osteoblast regeneration by a train of Erk activity waves. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. 
  • Effects of titanium particle size on osteoblast functions in vitro and in vivo. 
  • Electronic cigarette liquid exposure induces flavor-dependent osteotoxicity and increases expression of a key bone marker, collagen type I. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Fine needle aspiration of osteogenic sarcoma metastatic to the lung. A report of four cases. 
  • Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. 
  • Heal thyself: using endogenous regeneration to repair bone. 
  • High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. 
  • Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. 
  • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. 
  • Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. 
  • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. 
  • Impact of polymer-bound iodine on fibronectin adsorption and osteoblast cell morphology in radiopaque medical polymers: tyrosine-derived polycarbonate blends as a model system. 
  • Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD. 
  • In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. 
  • Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. 
  • Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. 
  • Lowering circulating apolipoprotein E levels improves aged bone fracture healing. 
  • Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. 
  • Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis. 
  • Mathematical modeling of Erk activity waves in regenerating zebrafish scales. 
  • Mathematical modeling of spatio-temporal dynamics of a single bone multicellular unit. 
  • Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. 
  • Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes. 
  • Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. 
  • Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. 
  • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. 
  • Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. 
  • Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. 
  • Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. 
  • Osteoprotegerin in bone metastases: mathematical solution to the puzzle. 
  • PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Pharmacologic targeting of β-catenin improves fracture healing in old mice. 
  • Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. 
  • Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. 
  • Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation. 
  • Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro. 
  • Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells. 
  • Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. 
  • Regeneration of amputated zebrafish fin rays from de novo osteoblasts. 
  • Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts. 
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • SLC1A5 provides glutamine and asparagine necessary for bone development in mice. 
  • SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation. 
  • Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Spine Patterning Is Guided by Segmentation of the Notochord Sheath. 
  • Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. 
  • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. 
  • Surface protein characterization of human adipose tissue-derived stromal cells. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The dependence of MG63 osteoblast responses to (meth)acrylate-based networks on chemical structure and stiffness. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. 
  • The role of Meteorin-like in skeletal development and bone fracture healing. 
  • The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. 
  • Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity. 
  • Titanium with aligned, elongated pores for orthopedic tissue engineering applications. 
  • Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. 
  • Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. 
  • Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. 
  • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. 
  • Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. 
• 

  Keywords of People

  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Gall, Ken, Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology