Osteoclasts

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  Subject Areas on Research

  • 1,25-Dihydroxyvitamin D3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry. 
  • A quantitative histologic study of avian osteopetrotic bone demonstrating normal osteoclast numbers and increased osteoblastic activity. 
  • A quantitative histomorphometric comparison of 40 micron thick Paragon sections with 5 micron thick Goldner sections in the study of undecalcified bone. 
  • Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. 
  • Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts' coupling to osteoblasts. 
  • Bone loss, pain and inflammation: three faces of ACPA in RA pathogenesis. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response. 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. 
  • Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response. 
  • Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway. 
  • Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. 
  • Effects of Roux-en-Y Gastric Bypass on Osteoclast Activity and Bone Density in Morbidly Obese Patients with Type 2 Diabetes. 
  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. 
  • Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. 
  • Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. 
  • High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. 
  • Macrophage activation results in bone resorption. 
  • Medical management of Paget's disease of bone: indications for treatment and review of current therapies. 
  • NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. 
  • Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice. 
  • PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. 
  • Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. 
  • Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. 
  • Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. 
  • Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. 
  • Roles of autophagy in orthodontic tooth movement. 
  • STING suppresses bone cancer pain via immune and neuronal modulation. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? 
  • The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The origins and roles of osteoclasts in bone development, homeostasis and repair. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. 
  • p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. 
  • pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss. 
  • β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology