Osteogenesis

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  Subject Areas on Research

  • 'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? 
  • Aluminum deposition at the osteoid-bone interface. An epiphenomenon of the osteomalacic state in vitamin D-deficient dogs. 
  • An injectable method for noninvasive spine fusion. 
  • Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. 
  • Association between blood lead and the risk of amyotrophic lateral sclerosis. 
  • BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. 
  • BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. 
  • Bioactive surface modification of metal oxides via catechol-bearing modular peptides: multivalent-binding, surface retention, and peptide bioactivity. 
  • Biological basis of bone formation, remodeling, and repair-part III: biomechanical forces. 
  • Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling. 
  • Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro. 
  • Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling. 
  • Blood vessels engineered from human cells. 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone formation induced by BMP-2 in human osteosarcoma cells. 
  • Bone protection by inhibition of microRNA-182. 
  • Bone-associated gene evolution and the origin of flight in birds. 
  • CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. 
  • Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation. 
  • Cell-based gene therapy for repair of critical size defects in the rat fibula. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Comparative rates of development in Monodelphis and Didelphis. 
  • Comparative studies of prosthetic materials in the left atrium of the dog. 
  • Comparison of guided bone formation from periosteum and muscle fascia. 
  • Concentration-Dependent hMSC Differentiation on Orthogonal Concentration Gradients of GRGDS and BMP-2 Peptides. 
  • Congenital abnormalities of the thoracic and lumbar spine. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Cranial osteogenesis in Monodelphis domestica (Didelphidae) and Macropus eugenii (Macropodidae). 
  • Debridement, Curettage, and Bone Marrow Stimulation: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. 
  • Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. 
  • Differentiation of adipose stem cells. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. 
  • EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. 
  • Effect of age on biomaterial-mediated in situ bone tissue regeneration. 
  • Effect of porous orthopaedic implant material and structure on load sharing with simulated bone ingrowth: A finite element analysis comparing titanium and PEEK. 
  • Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies. 
  • Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis. 
  • Evaluation of pectus bar position and osseous bone formation. 
  • Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. 
  • Genetic engineering of mesenchymal stem cells and its application in human disease therapy. 
  • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells. 
  • In vivo evaluation of plasmid DNA encoding OP-1 protein for spine fusion. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Increased glutamine catabolism mediates bone anabolism in response to WNT signaling. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels. 
  • Influence of lead on mineralization during bone growth. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. 
  • Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. 
  • Metatarsal lengthening by distraction osteogenesis: a report of two cases. 
  • Mice lacking Bmp6 function. 
  • Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. 
  • OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells. 
  • Osteopenia and osteoporosis in pediatric patients after stem cell transplant. 
  • Ovine model for engineering bone segments. 
  • PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. 
  • PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia. 
  • Periosteum-guided prefabrication of vascularized bone of clinical shape and volume. 
  • Poly(alpha-hydroxy acids): carriers for bone morphogenetic proteins. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Porous PEEK improves the bone-implant interface compared to plasma-sprayed titanium coating on PEEK. 
  • Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. 
  • Proliferation and differentiation of human mesenchymal stem cell encapsulated in polyelectrolyte complexation fibrous scaffold. 
  • Regulation of chondrogenesis and chondrocyte differentiation by stress. 
  • Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs. 
  • Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • Scaffold-based rhBMP-2 therapy in a rat alveolar defect model: implications for human gingivoperiosteoplasty. 
  • Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. 
  • Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. 
  • Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture. 
  • Stereoselective synthesis and osteogenic activity of subglutinols A and B. 
  • Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. 
  • Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. 
  • T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. 
  • TCDD disrupts hypural skeletogenesis during medaka embryonic development. 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • The DVR gene family in embryonic development. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The development of the upper end of the femur, with special reference to its internal architecture. 
  • The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm. 
  • The viability of cells obtained using the Reamer-Irrigator-Aspirator system and in bone graft from the iliac crest. 
  • Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity. 
  • Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique. 
  • Titanium surface characteristics, including topography and wettability, alter macrophage activation. 
  • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. 
  • Use of a revascularized, tubed costal myoperiosteal graft for repair of circumferential, segmental tracheal defects. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Olson, Steven Arthur, Professor of Orthopaedic Surgery, Orthopaedics