Ovary

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  Subject Areas on Research

  • 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator. 
  • A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. 
  • Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants. 
  • Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 2. 
  • Alterations in luteal phase progesterone and estradiol production after leuprolide acetate therapy before ovarian stimulation for in vitro fertilization. 
  • Application of a modified 203Hg binding assay for metallothionein. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. 
  • BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells. 
  • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. 
  • Bioaccumulation and speciation of selenium in fish and insects collected from a mountaintop removal coal mining-impacted stream in West Virginia. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. 
  • Cellular and molecular pathways regulating mammalian sex determination. 
  • Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle. 
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells. 
  • Citation for the 1998 Gerald D. Aurbach Lecture Award of the Endocrine Society to Dr. JoAnne S. Richards. 
  • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. 
  • Common variants at 19p13 are associated with susceptibility to ovarian cancer. 
  • Comparison of the ultrasonic scalpel to CO2 laser and electrosurgery in terms of tissue injury and adhesion formation in a rabbit model. 
  • Compartmental ovarian steroidogenesis in polycystic ovary syndrome. 
  • Constitutive production of macrophage colony-stimulating factor and interleukin-6 by human ovarian surface epithelial cells. 
  • Coordinate expression of urinary-type plasminogen activator and its receptor accompanies malignant transformation of the ovarian surface epithelium. 
  • Cushing syndrome, sexual precocity, and polyostotic fibrous dysplasia (Albright syndrome) in infancy. 
  • DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells. 
  • Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta). 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 
  • Differential replication of satellite DNA in polyploid tissues of Drosophila virilis. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Dynamic reciprocity between cells and their microenvironment in reproduction. 
  • Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases. 
  • EFFECTS OF 6 ALPHA-METHYL-17-ACETOXYPROGESTERONE, 17 ALPHA-ETHYNYL-19-NORTESTOSTERONE, PROGESTERONE, AND TESTOSTERONE PROPIONATE ON THE ADRENALS, GONADS, AND BURSA OF FABRICIUS OF THE CHICKEN. 
  • ELECTROPHORETIC SEPARATION OF HYDROLYTIC ENZYMES OF THE FEMALE RAT REPRODUCTIVE TRACT. 
  • Effect of hysterectomy with ovarian preservation on ovarian function. 
  • Effects of charcoal-extracted follicular fluid on reproductive function in postpartum cows. 
  • Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. 
  • Embolic microspheres within ovarian arterial vasculature after uterine artery embolization. 
  • Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer. 
  • Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. II. Relationship between receptor expression and response to epidermal growth factor. 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Equivalency of human menopausal gonadotropin and follicle-stimulating hormone stimulation after gonadotropin-releasing hormone agonist suppression. 
  • Etiology of closure-related adhesion formation after wedge resection of the rabbit ovary. 
  • Eukaryotic gene transcription with purified components. 
  • Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. 
  • Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Further studies on the role of the gonads in determining the ontogeny of gonadotropin secretion in the guinea pig (Cavia porcelus). 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • Gene expression patterns that characterize advanced stage serous ovarian cancers. 
  • Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta). 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Gonad morphogenesis in vertebrates: divergent means to a convergent end. 
  • Growth inhibition and metallothionein induction in cadmium-resistant cells by essential and non-essential metals. 
  • Growth regulation and transformation of ovarian epithelium. 
  • Helicobacter infection decreases reproductive performance of IL10-deficient mice. 
  • High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. 
  • High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA. 
  • Human ovarian cancer of the surface epithelium. 
  • Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats. 
  • Identification of genes associated with ovarian cancer metastasis using microarray expression analysis. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis. 
  • Increased blood pressure in mice lacking cytochrome P450 2J5. 
  • Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. 
  • Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. 
  • Long-term results of therapy for stage C neuroblastoma. 
  • Male-to-female sex reversal in mice lacking fibroblast growth factor 9. 
  • Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. 
  • Measuring rates of sexual development in female Mongolian gerbils. 
  • Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. 
  • Mutation and overexpression of p53 in early-stage epithelial ovarian cancer. 
  • Non-functional ovarian cysts do not affect ipsilateral or contralateral ovarian performance during in-vitro fertilization. 
  • Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. 
  • Number of pregnancies and ovariectomy modify mammary carcinoma development in transgenic HER-2/neu female mice. 
  • Observations of tissue response to acoustic radiation force: opportunities for imaging. 
  • One tissue, two fates: molecular genetic events that underlie testis versus ovary development. 
  • Ovarian epithelium regeneration by Lgr5(+) cells. 
  • Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis. 
  • Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with polyangiitis (Wegener's). 
  • Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone. 
  • Ovarian stimulation for in vitro fertilization using pure follicle-stimulating hormone with and without gonadotropin-releasing hormone agonist in high-responder patients. 
  • Ovarian vein thrombosis in oncology patients: CT detection and clinical significance. 
  • Ovarian vein thrombosis: incidence of recurrent venous thromboembolism and survival. 
  • Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas. 
  • Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. 
  • Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. 
  • Predetermination of sexual fate in a turtle with temperature-dependent sex determination. 
  • Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin. 
  • Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. 
  • Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta. 
  • Prostaglandin F 2 alpha production by the human ovary. 
  • Prostaglandin F2alpha levels in human ovarian plasma in pregnancy and in a case of Halban's disease. 
  • Radiation synovectomy with 165Dy-FHMA: lymph node uptake and radiation dosimetry calculations. 
  • Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. 
  • Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. 
  • Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta. 
  • Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta. 
  • Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells. 
  • Results of in vitro fertilization attempts in patients with one or two ovaries. 
  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice. 
  • Role of placental lactogen and prolactin in human pregnancy. 
  • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. 
  • Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. 
  • Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination. 
  • Significance of basal follicle-stimulating hormone levels in women with one ovary in a program of in vitro fertilization. 
  • Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. 
  • Stimulation protocols for patients with "atypical response". 
  • Stress affects uterine receptivity through an ovarian-independent pathway. 
  • Stretching the surface epithelium. 
  • Subcellular localization of the human immunodeficiency virus trans-acting art gene product. 
  • Suppression and flare regimens of gonadotropin-releasing hormone agonist. Use in women with different basal gonadotropin values in an in vitro fertilization program. 
  • Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. 
  • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. 
  • Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus. 
  • Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The battle of the sexes. 
  • The effect of interferon gamma on epidermal growth factor receptor expression in normal and malignant ovarian epithelial cells. 
  • The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle. 
  • The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. 
  • The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. 
  • The value of basal serum follicle stimulating hormone, luteinizing hormone and oestradiol concentrations following pituitary down-regulation in predicting ovarian response to stimulation with highly purified follicle stimulating hormone. 
  • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. 
  • Time-resolved MR angiography as a useful sequence for assessment of ovarian vein reflux. 
  • Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. 
  • Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. 
  • Use of gonadotrophin-releasing hormone agonists in controlled ovarian hyperstimulation for in vitro fertilization. 
  • Uterine blood flow: periodic fluctuations of its rate during pregnancy. 
  • Virilization during pregnancy associated with polycystic ovary disease. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • [Krukenberg tumor: a clinical case report]. 
  • ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. 
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  Keywords of People

  • Allen, Nancy Bates, Professor of Medicine, Medicine, Rheumatology and Immunology
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute
  • Myers, Evan Robert, Walter L. Thomas Professor of Obstetrics and Gynecology in the School of Medicine, Obstetrics and Gynecology