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Subject Areas on Research
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A closer inspection of tedizolid - authors' reply.
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A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome.
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
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Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240.
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Berninamycin. 2. Products of acidic hydrolysis, methanolysis, and acetolysis of berninamycin A1.
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Bimatoprost, prostamide activity, and conventional drainage.
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Casein kinase I in the mammalian circadian clock.
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Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B.
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Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH.
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Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids.
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Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.
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Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.
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Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex.
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Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.
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Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd-PHOX Catalyst.
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Enantioselective diene Cyclization/Hydrosilylation catalyzed by optically active palladium bisoxazoline and pyridine-oxazoline complexes.
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Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection.
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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
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Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy.
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Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
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High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma.
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Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.
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Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
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Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.
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Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
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Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.
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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
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N-methylated 5-alkenyloxazolium salt transformations.
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Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
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Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles.
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PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
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Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.
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Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
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Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
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Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
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Simultaneous stretching and contraction of stress fibers in vivo.
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Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.
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Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle.
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Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.
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Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.