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Subject Areas on Research
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2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism.
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57Fe and 1H electron-nuclear double resonance of three doubly reduced states Escherichia coli sulfite reductase.
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6-Methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity.
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A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
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A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii.
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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.
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Absence of hepatic molybdenum cofactor: an inborn error of metabolism leading to a combined deficiency of sulphite oxidase and xanthine dehydrogenase.
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Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1.
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Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1.
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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
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Activated conformers of Escherichia coli sulfite reductase heme protein subunit.
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Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
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Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.
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Alkaline low spin form of sulfite reductase hemeprotein subunit.
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Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices.
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Aminoanthracene is a mechanism-based inactivator of CYP1A in channel catfish hepatic tissue.
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An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides.
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An age-related difference in hyperoxia lethality: role of lung antioxidant defense mechanisms.
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An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases.
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Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.
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Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.
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Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'.
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Association of molybdopterin guanine dinucleotide with Escherichia coli dimethyl sulfoxide reductase: effect of tungstate and a mob mutation.
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Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.
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Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
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Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer.
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Ceramide synthase.
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Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment.
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Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin.
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Characterization of complexes between Escherichia coli sulfite reductase hemoprotein subunit and its substrates sulfite and nitrite.
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Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase.
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Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase.
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Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component.
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Chemistry and biology of the molybdenum cofactors.
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Chronic ethanol treatment induces H2O2 production selectively in pericentral regions of the liver lobule.
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Citrus CsACD2 Is a Target of Candidatus
Liberibacter Asiaticus in Huanglongbing Disease.
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Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
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Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans.
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Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells.
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Coordination environment for the type 3 copper center of tree laccase and CuB of cytochrome c oxidase as determined by electron nuclear double resonance.
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Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination.
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Crystallization and preliminary X-ray crystallographic studies of glutaredoxin 2 from Saccharomyces cerevisiae in different oxidation states.
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Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
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Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats.
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Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics.
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Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.
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Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.
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Domain interactions in oxidized and reduced forms of rat liver sulfite oxidase.
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Effect of conformation on the binding of flavins to flavoenzymes.
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Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.
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Effects of 2,4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish (Ictalurus punctatus).
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Effects of dietary pectin and cellulose on hepatic and intestinal mixed-function oxidations and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the rat.
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Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats.
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Efficacy of finasteride 1 mg in the treatment of androgenetic alopecia in men.
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Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands.
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Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and Fe4S4 prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit.
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Electron paramagnetic resonance of the tungsten derivative of rat liver sulfite oxidase.
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Electron-nuclear double resonance studies of oxidized Escherichia coli sulfite reductase: 1H, 14N, and 57Fe measurements.
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Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia.
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Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck.
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Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.
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Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes.
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Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.
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Evidence for siroheme-Fe4S4 interaction in spinach ferredoxin-sulfite reductase.
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Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome.
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Expression of nifH genes in natural microbial assemblages in Lake George, New York, detected by reverse transcriptase PCR.
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Flavin interaction in NADPH-sulfite reductase.
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Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements.
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Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.
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Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
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GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.
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Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis.
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Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.
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Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration.
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Glutaric aciduria type I: unusual biochemical presentation.
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Glutathione-dependent defense in channel catfish (Ictalurus punctatus) and brown bullhead (Ameriurus nebulosus).
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HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE.
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HEPATIC ALDEHYDE OXIDASE. II. DIFFERENTIAL INHIBITION OF ELECTRON TRANSFER TO VARIOUS ELECTRON ACCEPTORS.
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Heme-copper oxidases use tunneling pathways.
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Hepatic aldehyde oxidase. I. Purification and properties.
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Hepatic sulfite oxidase. Congruency in mitochondria of prosthetic groups and activity.
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Hepatic sulfite oxidase. Effect of anions on interaction with cytochrome c.
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Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide.
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Human sulfite oxidase deficiency. Characterization of the molecular defect in a multicomponent system.
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Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings.
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Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.
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Identification of quinone-binding and heme-ligating residues of the smallest membrane-anchoring subunit (QPs3) of bovine heart mitochondrial succinate:ubiquinone reductase.
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Identification of the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans as bis(molybdopterin guanine dinucleotide)molybdenum.
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In vitro reconstitution of demolybdosulfite oxidase by a molybdenum cofactor from rat liver and other sources.
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In vitro reconstitution of demolybdosulfite oxidase by molybdate.
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Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor.
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Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli.
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Interactions of oxygen radicals with airway epithelium.
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Isolation of -L-glutaminyl 4-hydroxybenzene and -L-glutaminyl 3,4-benzoquinone: a natural sulfhydryl reagent, from sporulating gill tissue of the mushroom Agaricus bisporus.
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Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
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Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase.
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L-carnitine therapy in isovaleric acidemia.
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Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone.
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MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma.
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Magnetization of the sulfite and nitrite complexes of oxidized sulfite and nitrite reductases: EPR silent spin S = 1/2 states.
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Mechanism of action of a respiratory inhibitor from the gill tissue of the sporulating common mushroom, Agaricus bisporus.
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Mechanism of assembly of the Bis(Molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase.
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Mechanisms of inactivation of molybdoenzymes by cyanide.
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Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy.
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Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.
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Molecular basis of the biological function of molybdenum. Developmental patterns of sulfite oxidase and xanthine oxidase in the rat.
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Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat.
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Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats.
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Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2.
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Molecular cloning of dimethyl sulfoxide reductase from Rhodobacter sphaeroides.
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Molybdopterin guanine dinucleotide: a modified form of molybdopterin identified in the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides forma specialis denitrificans.
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Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD.
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Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex.
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Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups.
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Mössbauer studies of Escherichia coli sulfite reductase complexes with carbon monoxide and cyanide. Exchange coupling and intrinsic properties of the [4Fe-4S] cluster.
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N. plumbaginifolia zeaxanthin epoxidase transgenic lines have unaltered baseline ABA accumulations in roots and xylem sap, but contrasting sensitivities of ABA accumulation to water deficit.
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New nitrogen-fixing microorganisms detected in oligotrophic oceans by amplification of Nitrogenase (nifH) genes.
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Nitroglycerine: relief from the heartache of decompression sickness?
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Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
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Observation of 17O effects on MoV EPR spectra in sulfite oxidase, xanthine dehydrogenase, and MoO(SC6H5)4-.
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Oxidant, mixed-function oxidase and peroxisomal responses in channel catfish exposed to a bleached kraft mill effluent.
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Oxidase Activity of the Barnacle Adhesive Interface Involves Peroxide-Dependent Catechol Oxidase and Lysyl Oxidase Enzymes.
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Oxidation of phenazine methosulfate by hepatic aldehyde oxidase.
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Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies.
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Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma.
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Pigment production from tryptophan by an Achromobacter species.
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Preliminary X-ray diffraction studies on the hemoprotein subunit of Escherichia coli sulfite reductase.
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Pulsed EPR studies of the exchangeable proton at the molybdenum center of dimethyl sulfoxide reductase.
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Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources.
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Purification and properties of sulfite oxidase from human liver.
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Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.
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Rat liver L-glutamate dehydrogenase, malate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, and sulfite oxidase are each synthesized as larger precursors by cytoplasmic free polysomes.
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Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. V. Studies with the Escherichia coli hemoflavoprotein depleted of flavin mononucleotide: distinct roles for the flavin adenine dinucleotide and flavin mononucleotide prosthetic groups in catalysis.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme.
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Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption.
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Regulation of the cyanide-resistant alternative oxidase of plant mitochondria. Identification of the cysteine residue involved in alpha-keto acid stimulation and intersubunit disulfide bond formation.
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Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.
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Resonance Raman characterization of biotin sulfoxide reductase. Comparing oxomolybdenum enzymes in the ME(2)SO reductase family.
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Resonance Raman spectroscopic characterization of the molybdopterin active site of DMSO reductase.
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Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes.
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Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 2. Fe4S4 cluster vibrational modes.
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Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes.
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Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.
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Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.
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STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS.
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Sequence basis of Barnacle Cement Nanostructure is Defined by Proteins with Silk Homology.
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Significance of bound glutarate in the diagnosis of glutaric aciduria type I.
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Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases.
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Siroheme: a new prosthetic group participating in six-electron reduction reactions catalyzed by both sulfite and nitrite reductases.
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Sirohydrochlorin. Prosthetic group of a sulfite reductase enzyme and its role in the biosynthesis of vitamin B12.
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Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration.
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Spectroscopic studies of the molybdenum-containing dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans.
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Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
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Spinach siroheme enzymes: Isolation and characterization of ferredoxin-sulfite reductase and comparison of properties with ferredoxin-nitrite reductase.
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Structural and metabolic relationship between the molybdenum cofactor and urothione.
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Structural studies of the heme domain of sulfite oxidase: CNBr fragments.
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Structure of the molybdenum site of Rhodobacter sphaeroides biotin sulfoxide reductase.
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Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states.
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Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing.
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Studies of vanadium toxicity in the rat. Lack of correlation with molybdenum utilization.
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Sulfite oxidase deficiency.
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Sulfite oxidase deficiency. Biochemical and clinical investigations of a hereditary metabolic disorder in sulfur metabolism.
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Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme.
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Superoxidized states of Escherichia coli sulfite reductase heme protein subunit.
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Sutterella wadsworthensis gen. nov., sp. nov., bile-resistant microaerophilic Campylobacter gracilis-like clinical isolates.
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T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.
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THE ABSORPTION SPECTRA OF IRON-FLAVOPROTEINS.
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Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
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The domains of rat liver sulfite oxidase. Proteolytic separation and characterization.
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The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase.
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The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria.
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The role of duodenal cytochrome b in intestinal iron absorption remains unclear.
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The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol.
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The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain.
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The state of reduction of molybdopterin in xanthine oxidase and sulfite oxidase.
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The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase.
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Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains.
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Two crystal forms of bovine superoxide dismutase.
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Vitamin A and biochemical development. II. Effect of postnatal excess vitamin-A administration on the activity of pyridine nucleotide-linked dehydrogenases.
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Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase.
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[Value of the determination of lactic dehydrase in the etiological diagnosis of serous effusions].
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