Oxidoreductases

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  Subject Areas on Research

  • 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism. 
  • 57Fe and 1H electron-nuclear double resonance of three doubly reduced states Escherichia coli sulfite reductase. 
  • 6-Methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Absence of hepatic molybdenum cofactor: an inborn error of metabolism leading to a combined deficiency of sulphite oxidase and xanthine dehydrogenase. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1. 
  • Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. 
  • Activated conformers of Escherichia coli sulfite reductase heme protein subunit. 
  • Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. 
  • Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide. 
  • Alkaline low spin form of sulfite reductase hemeprotein subunit. 
  • Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices. 
  • Aminoanthracene is a mechanism-based inactivator of CYP1A in channel catfish hepatic tissue. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An age-related difference in hyperoxia lethality: role of lung antioxidant defense mechanisms. 
  • An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. 
  • Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Association of molybdopterin guanine dinucleotide with Escherichia coli dimethyl sulfoxide reductase: effect of tungstate and a mob mutation. 
  • Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. 
  • Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss. 
  • Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. 
  • Ceramide synthase. 
  • Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment. 
  • Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. 
  • Characterization of complexes between Escherichia coli sulfite reductase hemoprotein subunit and its substrates sulfite and nitrite. 
  • Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase. 
  • Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase. 
  • Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component. 
  • Chemistry and biology of the molybdenum cofactors. 
  • Chronic ethanol treatment induces H2O2 production selectively in pericentral regions of the liver lobule. 
  • Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease. 
  • Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Coordination environment for the type 3 copper center of tree laccase and CuB of cytochrome c oxidase as determined by electron nuclear double resonance. 
  • Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. 
  • Crystallization and preliminary X-ray crystallographic studies of glutaredoxin 2 from Saccharomyces cerevisiae in different oxidation states. 
  • Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. 
  • Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats. 
  • Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics. 
  • Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics. 
  • Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. 
  • Domain interactions in oxidized and reduced forms of rat liver sulfite oxidase. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. 
  • Effects of 2,4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish (Ictalurus punctatus). 
  • Effects of dietary pectin and cellulose on hepatic and intestinal mixed-function oxidations and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the rat. 
  • Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats. 
  • Efficacy of finasteride 1 mg in the treatment of androgenetic alopecia in men. 
  • Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands. 
  • Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and Fe4S4 prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit. 
  • Electron paramagnetic resonance of the tungsten derivative of rat liver sulfite oxidase. 
  • Electron-nuclear double resonance studies of oxidized Escherichia coli sulfite reductase: 1H, 14N, and 57Fe measurements. 
  • Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia. 
  • Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck. 
  • Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. 
  • Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes. 
  • Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. 
  • Evidence for siroheme-Fe4S4 interaction in spinach ferredoxin-sulfite reductase. 
  • Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. 
  • Expression of nifH genes in natural microbial assemblages in Lake George, New York, detected by reverse transcriptase PCR. 
  • Flavin interaction in NADPH-sulfite reductase. 
  • Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements. 
  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. 
  • GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. 
  • Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. 
  • Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23. 
  • Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration. 
  • Glutaric aciduria type I: unusual biochemical presentation. 
  • Glutathione-dependent defense in channel catfish (Ictalurus punctatus) and brown bullhead (Ameriurus nebulosus). 
  • HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. 
  • HEPATIC ALDEHYDE OXIDASE. II. DIFFERENTIAL INHIBITION OF ELECTRON TRANSFER TO VARIOUS ELECTRON ACCEPTORS. 
  • Heme-copper oxidases use tunneling pathways. 
  • Hepatic aldehyde oxidase. I. Purification and properties. 
  • Hepatic sulfite oxidase. Congruency in mitochondria of prosthetic groups and activity. 
  • Hepatic sulfite oxidase. Effect of anions on interaction with cytochrome c. 
  • Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide. 
  • Human sulfite oxidase deficiency. Characterization of the molecular defect in a multicomponent system. 
  • Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings. 
  • Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. 
  • Identification of quinone-binding and heme-ligating residues of the smallest membrane-anchoring subunit (QPs3) of bovine heart mitochondrial succinate:ubiquinone reductase. 
  • Identification of the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans as bis(molybdopterin guanine dinucleotide)molybdenum. 
  • In vitro reconstitution of demolybdosulfite oxidase by a molybdenum cofactor from rat liver and other sources. 
  • In vitro reconstitution of demolybdosulfite oxidase by molybdate. 
  • Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. 
  • Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli. 
  • Interactions of oxygen radicals with airway epithelium. 
  • Isolation of -L-glutaminyl 4-hydroxybenzene and -L-glutaminyl 3,4-benzoquinone: a natural sulfhydryl reagent, from sporulating gill tissue of the mushroom Agaricus bisporus. 
  • Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. 
  • Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase. 
  • L-carnitine therapy in isovaleric acidemia. 
  • Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone. 
  • MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. 
  • Magnetization of the sulfite and nitrite complexes of oxidized sulfite and nitrite reductases: EPR silent spin S = 1/2 states. 
  • Mechanism of action of a respiratory inhibitor from the gill tissue of the sporulating common mushroom, Agaricus bisporus. 
  • Mechanism of assembly of the Bis(Molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase. 
  • Mechanisms of inactivation of molybdoenzymes by cyanide. 
  • Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. 
  • Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio. 
  • Molecular basis of the biological function of molybdenum. Developmental patterns of sulfite oxidase and xanthine oxidase in the rat. 
  • Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats. 
  • Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2. 
  • Molecular cloning of dimethyl sulfoxide reductase from Rhodobacter sphaeroides. 
  • Molybdopterin guanine dinucleotide: a modified form of molybdopterin identified in the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides forma specialis denitrificans. 
  • Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD. 
  • Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex. 
  • Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. 
  • Mössbauer studies of Escherichia coli sulfite reductase complexes with carbon monoxide and cyanide. Exchange coupling and intrinsic properties of the [4Fe-4S] cluster. 
  • N. plumbaginifolia zeaxanthin epoxidase transgenic lines have unaltered baseline ABA accumulations in roots and xylem sap, but contrasting sensitivities of ABA accumulation to water deficit. 
  • New nitrogen-fixing microorganisms detected in oligotrophic oceans by amplification of Nitrogenase (nifH) genes. 
  • Nitroglycerine: relief from the heartache of decompression sickness? 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • Observation of 17O effects on MoV EPR spectra in sulfite oxidase, xanthine dehydrogenase, and MoO(SC6H5)4-. 
  • Oxidant, mixed-function oxidase and peroxisomal responses in channel catfish exposed to a bleached kraft mill effluent. 
  • Oxidase Activity of the Barnacle Adhesive Interface Involves Peroxide-Dependent Catechol Oxidase and Lysyl Oxidase Enzymes. 
  • Oxidation of phenazine methosulfate by hepatic aldehyde oxidase. 
  • Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. 
  • Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. 
  • Pigment production from tryptophan by an Achromobacter species. 
  • Preliminary X-ray diffraction studies on the hemoprotein subunit of Escherichia coli sulfite reductase. 
  • Pulsed EPR studies of the exchangeable proton at the molybdenum center of dimethyl sulfoxide reductase. 
  • Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources. 
  • Purification and properties of sulfite oxidase from human liver. 
  • Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. 
  • Rat liver L-glutamate dehydrogenase, malate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, and sulfite oxidase are each synthesized as larger precursors by cytoplasmic free polysomes. 
  • Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. V. Studies with the Escherichia coli hemoflavoprotein depleted of flavin mononucleotide: distinct roles for the flavin adenine dinucleotide and flavin mononucleotide prosthetic groups in catalysis. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme. 
  • Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. 
  • Regulation of the cyanide-resistant alternative oxidase of plant mitochondria. Identification of the cysteine residue involved in alpha-keto acid stimulation and intersubunit disulfide bond formation. 
  • Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort. 
  • Resonance Raman characterization of biotin sulfoxide reductase. Comparing oxomolybdenum enzymes in the ME(2)SO reductase family. 
  • Resonance Raman spectroscopic characterization of the molybdopterin active site of DMSO reductase. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 2. Fe4S4 cluster vibrational modes. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. 
  • Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. 
  • Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. 
  • STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS. 
  • Sequence basis of Barnacle Cement Nanostructure is Defined by Proteins with Silk Homology. 
  • Significance of bound glutarate in the diagnosis of glutaric aciduria type I. 
  • Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Siroheme: a new prosthetic group participating in six-electron reduction reactions catalyzed by both sulfite and nitrite reductases. 
  • Sirohydrochlorin. Prosthetic group of a sulfite reductase enzyme and its role in the biosynthesis of vitamin B12. 
  • Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration. 
  • Spectroscopic studies of the molybdenum-containing dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans. 
  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Spinach siroheme enzymes: Isolation and characterization of ferredoxin-sulfite reductase and comparison of properties with ferredoxin-nitrite reductase. 
  • Structural and metabolic relationship between the molybdenum cofactor and urothione. 
  • Structural studies of the heme domain of sulfite oxidase: CNBr fragments. 
  • Structure of the molybdenum site of Rhodobacter sphaeroides biotin sulfoxide reductase. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing. 
  • Studies of vanadium toxicity in the rat. Lack of correlation with molybdenum utilization. 
  • Sulfite oxidase deficiency. 
  • Sulfite oxidase deficiency. Biochemical and clinical investigations of a hereditary metabolic disorder in sulfur metabolism. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Superoxidized states of Escherichia coli sulfite reductase heme protein subunit. 
  • Sutterella wadsworthensis gen. nov., sp. nov., bile-resistant microaerophilic Campylobacter gracilis-like clinical isolates. 
  • T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis. 
  • THE ABSORPTION SPECTRA OF IRON-FLAVOPROTEINS. 
  • Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. 
  • The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. 
  • The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase. 
  • The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria. 
  • The role of duodenal cytochrome b in intestinal iron absorption remains unclear. 
  • The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol. 
  • The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. 
  • The state of reduction of molybdopterin in xanthine oxidase and sulfite oxidase. 
  • The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase. 
  • Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains. 
  • Two crystal forms of bovine superoxide dismutase. 
  • Vitamin A and biochemical development. II. Effect of postnatal excess vitamin-A administration on the activity of pyridine nucleotide-linked dehydrogenases. 
  • Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase. 
  • [Value of the determination of lactic dehydrase in the etiological diagnosis of serous effusions]. 
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  Keywords of People

  • Beratan, David N., R.J. Reynolds Distinguished Professor of Chemistry, Nicholas Institute-Energy Initiative