Oxidoreductases, N-Demethylating
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Subject Areas on Research
- 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
- Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity.
- Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.
- Biotransformation of sevoflurane.
- Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog.
- Clinical enflurane metabolism by cytochrome P450 2E1.
- Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.
- Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.
- Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.
- Effect of age and gender on the activity of human hepatic CYP3A.
- Effect of normal aging on the activity of human hepatic cytochrome P450IIE1.
- Effects of carbon tetrachloride on adrenocortical structure and function in guinea pigs.
- Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
- Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
- HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.
- Hepatic cytochrome P-4503A (CYP3A) activity in the elderly.
- Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes).
- Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
- Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
- Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.
- Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes).
- Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
- Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
- Mechanism of autoinduction of methadone N-demethylation in human hepatocytes.
- Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.
- Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
- Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
- Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.
- Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.
- MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
- Molecular characterization of CYP2B6 substrates.
- N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
- Opposing LSD1 complexes function in developmental gene activation and repression programmes.
- Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.
- Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.
- Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture.
- Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor.
- Role of CYP2B6 in stereoselective human methadone metabolism.
- Role of cytochrome P4502B6 in methadone metabolism and clearance.
- Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
- Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.
- Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
- Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
- Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
- Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.
- Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.
- The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients.
- Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
- Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1.
- trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.