Oxidoreductases, N-Demethylating
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Subject Areas on Research
- 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
- Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity.
- Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.
- DEET (N,N-diethyl-m-toluamide) alone and in combination with permethrin increased urinary excretion of 6beta-hydroxycortisol in rats, a marker of hepatic CYP3A induction.
- Effect of age and gender on the activity of human hepatic CYP3A.
- Effect of normal aging on the activity of human hepatic cytochrome P450IIE1.
- Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
- HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.
- Hepatic cytochrome P-4503A (CYP3A) activity in the elderly.
- Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
- Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes).
- Induction of cytochrome P450 isozymes by simultaneous inhalation exposure of hens to n-hexane and methyl iso-butyl ketone (MiBK).
- Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis.
- MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
- N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
- Opposing LSD1 complexes function in developmental gene activation and repression programmes.
- Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.
- Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture.
- Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor.
- The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients.
- Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene.
- trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.