Subject Areas on Research
- A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
- Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerases.
- Influenza research in the Soviet Union--1974.
- Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.
- Mutations of the bacteriophage T4 type II DNA topoisomerase that alter sensitivity to antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide and an antibacterial quinolone.