Pancreatic Elastase
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Subject Areas on Research
- A multi-center, dose-escalation study of human type I pancreatic elastase (PRT-201) administered after arteriovenous fistula creation.
- Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.
- Age and functional correlations of markers of coagulation and inflammation in the elderly: functional implications of elevated crosslinked fibrin degradation products (D-dimers).
- Aging and dietary modulation of elastase and interleukin-1 beta secretion.
- Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation.
- An unusual specificity in the activation of neutrophil serine proteinase zymogens.
- Animal models in the research of abdominal aortic aneurysms development.
- Anti-inflammatory effects of pentoxifylline in claudication.
- Cell migration through defined, synthetic ECM analogs.
- Characteristics of the chemotactic activity of heparin cofactor II proteolysis products.
- Characterization of prorenin activation using a synthetic peptide substrate.
- Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade?
- Cleavage of membrane-bound C3b and C3bi by viable human neutrophils (PMN).
- Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
- Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes.
- Early changes of lung function and structure in an elastase model of emphysema—a hyperpolarized 3He MRI study
- Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein.
- Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential.
- Evidence that calpains and elastase do not produce the von Willebrand factor fragments present in normal plasma and IIA von Willebrand disease.
- Fibrinolysis and fibrinogenolysis by Val442-plasmin.
- Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity.
- Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.
- Human neutrophils release serine proteases capable of activating prorenin.
- In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors.
- Leukocyte chemoattractant peptides from the serpin heparin cofactor II.
- Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II).
- Molecular phenotype of airway side population cells.
- Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
- Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
- Pancreatitis: the acid test.
- Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.
- Pseudomonas aeruginosa elastase degrades surfactant proteins A and D.
- Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.
- Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB.
- Serum Calprotectin as a Novel Biomarker in Abdominal Aortic Aneurysm Pathogenesis and Progression: Preliminary Data from Experimental Model in Rats.
- The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels.
- The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin.
- The role of inter-alpha-trypsin inhibitor and other proteinase inhibitors in the plasma clearance of neutrophil elastase and plasmin.
- Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure.
- Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases.
- alpha-Macroglobulins: detection and characterization.