Parathyroid Hormone

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  Subject Areas on Research

  • (1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers. 
  • 1,25-Dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. 
  • 25-Hydroxyvitamin D therapy in children with active juvenile rheumatoid arthritis: short-term effects on serum osteocalcin levels and bone mineral density. 
  • A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan. 
  • A Prospective Cohort Study of Mineral Metabolism After Kidney Transplantation. 
  • A quantitative histomorphometric comparison of 40 micron thick Paragon sections with 5 micron thick Goldner sections in the study of undecalcified bone. 
  • A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. 
  • Abnormal bone turnover in cystic fibrosis adults. 
  • Abnormal parathyroid function in the X-linked hypophosphatemic mouse. 
  • Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the hypophosphatemic mouse. Evidence for a generalized defect of vitamin D metabolism. 
  • Acid Load and Phosphorus Homeostasis in CKD. 
  • Activated injectable vitamin D and hemodialysis survival: a historical cohort study. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism. 
  • An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. 
  • An overview of calcium homeostasis in humans. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Association of parathyroid pathology with well-differentiated thyroid carcinoma. 
  • Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease. 
  • Biomarkers of Mineral and Bone Metabolism and 20-Year Risk of Hospitalization With Infection: The Atherosclerosis Risk in Communities Study. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia. 
  • Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects. 
  • Changes in protein-bound, complex-bound, and ionized calcium related to parathyroid hormone levels in healthy donors during plateletapheresis. 
  • Circadian rhythms for calcium, inorganic phosphorus, and parathyroid hormone in primary hyperparathyroidism: functional and practical considerations. 
  • Complementary nature of radiotracer parathyroid imaging and intraoperative parathyroid hormone assays in the surgical management of primary hyperparathyroid disease: case report and review. 
  • Concurrent sporadic parathyroid adenoma and carcinoma. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Correlation of intraoperative parathyroid hormone levels with parathyroid gland size. 
  • Correlations of serum concentrations of 1,25-dihydroxyvitamin D, phosphorus, and parathyroid hormone in tumoral calcinosis. 
  • Daily variability in mineral metabolites in CKD and effects of dietary calcium and calcitriol. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Determinants of 25-hydroxyvitamin D levels in African-American and Caucasian male veterans. 
  • Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. 
  • Disordered FGF23 and mineral metabolism in children with CKD. 
  • Diuretics, calciuria and secondary hyperparathyroidism in the Chronic Renal Insufficiency Cohort. 
  • Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion. 
  • Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs). 
  • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 
  • Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. 
  • Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. 
  • Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. 
  • Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials. 
  • Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. 
  • Effects of calcitriol and non-calcemic vitamin D analogs on secondary hyperparathyroidism. 
  • Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. 
  • Effects of phosphate binders in moderate CKD. 
  • Effects of short-term administration of glucocorticoids on bone metabolism in healthy elderly men. 
  • Effects of two models of hypercalcemia on renal acid base metabolism. 
  • Electrophysiological correlates of secretion in normal human parathyroid cells. 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality. 
  • Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia. 
  • Evidence basis for integrated management of mineral metabolism in patients with end-stage renal disease. 
  • Experimental cryopreservation and autotransplantation of parathyroid glands: technique and demonstration of function. 
  • Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells. 
  • FGF-23 levels in patients with AKI and risk of adverse outcomes. 
  • FGF23 or PTH: which comes first in CKD ? 
  • Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. 
  • Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. 
  • Fibroblast Growth Factor-23 and a Vegetarian Diet. 
  • Fibroblast growth factor 23 in patients undergoing peritoneal dialysis. 
  • Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. 
  • Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Forging forward with 10 burning questions on FGF23 in kidney disease. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • GFR-Specific versus GFR-Agnostic Cutoffs for Parathyroid Hormone and Fibroblast Growth Factor-23 in Advanced Chronic Kidney Disease. 
  • Genetic Variants Associated with Circulating Parathyroid Hormone. 
  • Healing of bone disease in X-linked hypophosphatemic rickets/osteomalacia. Induction and maintenance with phosphorus and calcitriol. 
  • Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage. 
  • Hypercalcemia following acute renal failure. 
  • Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure. 
  • Hypoparathyroidism after I-131 therapy with subsequent return of parathyroid function. 
  • Hypoparathyroidism: a possible cause of osteomalacia . 
  • Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. 
  • In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia. 
  • Incidence of multiglandular disease in primary hyperparathyroidism determined by parathyroid hormone secretion. 
  • Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. 
  • Influence of continuous infusion of citrate on responses of immunoreactive parathyroid hormone, calcium and magnesium components, and other electrolytes in normal adults during plateletapheresis. 
  • Initial experience with intraoperative PTH determinations in the surgical management of 130 consecutive cases of primary hyperparathyroidism. 
  • Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia. 
  • Intraoperative parathyroid hormone monitoring during parathyroidectomy for secondary hyperparathyroidism. 
  • Leontiasis ossea in secondary hyperparathyroidism. 
  • Long-term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation. 
  • Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. 
  • Mineral metabolites and CKD progression in African Americans. 
  • Newer knowledge of vitamin D and its metabolites in health and disease. 
  • Non-autonomy of parathyroid hormone secretion in acute primary hyperparathyroidism. 
  • Normal calcitonin stimulation of serum calcitriol in patients with X-linked hypophosphatemic rickets. 
  • Osteomalacia after parathyroidectomy in patients with uremia. 
  • Osteomalacia in chronic renal failure: a syndrome previously reported only with maintenance dialysis. 
  • PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. 
  • PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. 
  • Parathyroid Hormone and the Use of Diuretics and Calcium-Channel Blockers: The Multi-Ethnic Study of Atherosclerosis. 
  • Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. 
  • Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity. 
  • Parathyroid hormone independently predicts fracture, vascular events, and death in patients with stage 3 and 4 chronic kidney disease. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. 
  • Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas. 
  • Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro. 
  • Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study. 
  • Pivoting From PTH to FGF23 to Mend Breaking Hearts on Dialysis. 
  • Plant protein intake is associated with fibroblast growth factor 23 and serum bicarbonate levels in patients with chronic kidney disease: the Chronic Renal Insufficiency Cohort study. 
  • Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS). 
  • Plasma FGF23 levels increase rapidly after acute kidney injury. 
  • Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'? 
  • Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. 
  • Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD. 
  • Predictors of short-term changes in serum intact parathyroid hormone levels in hemodialysis patients: role of phosphorus, calcium, and gender. 
  • Primary hyperparathyroidism in dogs. 
  • Primary hyperparathyroidism. 
  • Primary hyperparathyroidism: a new experimental animal model. 
  • Progress in the operative management of sporadic primary hyperparathyroidism over 34 years. 
  • Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Pseudohypoparathyroidism type II: a possible defect in the reception of the cyclic AMP signal. 
  • Quantitative analysis of the calcium-sensing receptor messenger RNA in parathyroid adenomas. 
  • Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis. 
  • Racial differences in postprandial mineral ion handling in health and in chronic kidney disease. 
  • Rare Complication of Sclerochoroidal Calcifications. 
  • Regulation of calcium appetite in broiler chickens. 
  • Regulation of serum 1,25-dihydroxyvitamin D3 in lactating rats. 
  • Regulation of the renal Na+-H+ exchanger by protein phosphorylation. 
  • Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. 
  • Renal cyclic adenosine monophosphate: an accurate index of parathyroid function. 
  • Renal proximal tubule cells: power and finesse. 
  • Risk Factors for and Effects of Persistent and Severe Hypophosphatemia Following Ferric Carboxymaltose. 
  • Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women. 
  • Serum ionized calcium may be related to white matter lesion volumes in older adults: a pilot study. 
  • Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. 
  • Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users. 
  • Should activated vitamin D be used in patients with end-stage renal disease and low levels of parathyroid hormone? 
  • Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. 
  • Spontaneous hypercalcemia in patients undergoing dialysis. Etiologic and therapeutic considerations. 
  • Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. 
  • Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. 
  • The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. 
  • The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets. 
  • The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat. 
  • The effect of high-dose salmon calcitonin on bone mineral metabolism in the normal rat. 
  • The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia. 
  • The final intraoperative parathyroid hormone level: how low should it go? 
  • The metabolic effects of calcium supplementation in the elderly. 
  • The response of circulating parameters of bone mineral metabolism to ethanol- and EDTA-induced hypocalcemia in the rat. 
  • The response of parathyroid hormone to specific changes in either ionized calcium, ionized magnesium, or protein-bound calcium in humans. 
  • The role of circulating N-terminal parathyroid hormone fragments in the early postparathyroid adenomectomy period. 
  • The small abnormal parathyroid gland is increasingly common and heralds operative complexity. 
  • The syndrome of hyperostosis and hyperphosphatemia. 
  • Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis. 
  • Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. 
  • Transplantation of the parathyroid glands in man: clinical indications and results. 
  • Trends in Mineral Metabolism Treatment Strategies in Patients Receiving Hemodialysis in the United States. 
  • Tumor-induced osteomalacia masking primary hyperparathyroidism. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Vitamin D deficiency and anemia in early chronic kidney disease. 
  • Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. 
  • Vitamin D levels and early mortality among incident hemodialysis patients. 
  • cAMP and calcemia. 
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  Keywords of People

  • Cohen, Seth Morris, Professor of Head and Neck Surgery & Communication Sciences, Head and Neck Surgery & Communication Sciences
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics