Pentobarbital

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  Subject Areas on Research

  • A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. 
  • Barbiturate and GABA receptors coupled to benzodiazepine receptors in rat hippocampal formation: a radiohistochemical study. 
  • Barbiturate effects on acetylcholine-activated channels in Aplysia neurons. 
  • Barbiturate enhancement of spike frequency adaptation in Aplysia giant neurons. 
  • Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. 
  • Barbiturate-induced slow outward currents in Aplysia neurones. 
  • Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes. 
  • Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding. 
  • Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. 
  • Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling. 
  • Depression of sustained evoked potentials and glial depolarization in the spinal cord by barbiturates and by diphenylhydantoin. 
  • Differential effects of phenobarbital and pentobarbital on stimulus train-induced bursting in the hippocampal slice. 
  • Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. 
  • Dynamic patterns of brain cell assemblies. IV. Mixed systems. Steady states and their shifts. Spinal cord studies. 
  • Effect of ethanol dependence on GABAA antagonist-induced seizures and agonist-stimulated chloride uptake. 
  • Effect of ozone on drug-induced sleeping time in mice pretreated with mixed-function oxidase inducers and inhibitors. 
  • Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia. 
  • Effects of isoflurane, pentobarbital, and urethane on apoptosis and apoptotic signal transduction in rat kidney. 
  • Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. 
  • Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia. 
  • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. 
  • Ethanol-induced hydrolysis of brain sialoglycoconjugates in the rat: effect of sialic acid in antagonizing ethanol intoxication. 
  • Factors modulating the sensitivity of the GABA receptor-gated chloride ion channel. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures. 
  • Helium: absence of antiarrhythmic effect in anesthetized dogs. 
  • Hippocampal afterdischarges and their post-ictal sequelae in rats: a potential tool for assessment of CNS neurotoxicity. 
  • Hypotensive effect of clonidine is not mediated by enhanced baroreflex gain in rats. 
  • Influence of ozone on pentobarbital pharmacokinetics in mice. 
  • Influence of ozone on pentobarbital-induced sleeping time in mice, rats, and hamsters. 
  • Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). 
  • Maturation of central nervous system control of growth hormone secretion in rats. 
  • Moderate sedation for MRI in young children with autism. 
  • Pharmacologic studies of the nature of the sympathetic nerves of the urinary bladder. 
  • Rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbitone sodium. 
  • Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. 
  • Regional myocardial blood flow in awake dogs. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital. 
  • Sustained evoked potential changes of the spinal cord. 
  • The dose-related effects of nitric oxide synthase inhibition on cerebral blood flow during isoflurane and pentobarbital anesthesia. 
  • The effect of pentobarbital anesthesia on the autonomic nervous system control of heart rate during baroreceptor activation. 
  • The influence of halothane, isoflurane, and pentobarbital on cerebral plasma volume in hypocapnic and normocapnic rats. 
  • The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypothermia, pentobarbital, and isoflurane. 
  • Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. 
  • Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion. 
  • gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel. 
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  Keywords of People

  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology