Peptide Hydrolases

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  Subject Areas on Research

  • 3D traction stresses activate protease-dependent invasion of cancer cells. 
  • A cytotoxic proteinase isolated from human lymphocytes. 
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. 
  • A novel human disease with abnormal prion protein sensitive to protease. 
  • A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice. 
  • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. 
  • Amino acid abundance and proteolytic potential in North American soils. 
  • Antibody-induced release of cellular proteinases: loss of adhesion of human melanoma cells after binding of anti-melanoma antibody. 
  • Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. 
  • Assembly of proteolytically cleaved tubulin. 
  • Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants. 
  • Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Cellular serine proteinase induces chemotaxis by complement activation. 
  • Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes. 
  • Characterization of a chemotactic and cytotoxic proteinase from human skin. 
  • Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor. 
  • Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. 
  • Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. 
  • Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders. 
  • Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. 
  • D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. 
  • Degradation of proteoglycan in articular cartilage. 
  • Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. 
  • Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat. 
  • Effect of proximal transposition of the ileum on mucosal growth and enzyme activity in orally nourished rats. 
  • Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases. 
  • Emerging targets in neuroinflammation-driven chronic pain. 
  • Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. 
  • Fluorescent probes as a measure of conformational alterations induced by nucleophilic modification and proteolysis of bovine alpha 2-macroglobulin. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA. 
  • Functional selection of protease inhibitory antibodies. 
  • Growth factor-regulated proteases and extracellular matrix remodeling during mammalian development. 
  • Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. 
  • Hepatic lysosomal enzymes in young rats fed retinol. 
  • Hepatocyte receptors for antithrombin III-proteinase complexes. 
  • Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin. 
  • Human recombinant interleukin-1 alpha increases elastase-like enzyme in human uterine cervical fibroblasts. 
  • Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. 
  • Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. 
  • Immunological mechanisms of periodontal tissue destruction. 
  • In vitro proteolysis of a large subunit of Drosophila melanogaster RNA polymerase B. 
  • Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. 
  • Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control. 
  • Intestinal brush border peptidases: activities in normal and abnormal peroral intestinal biopsy specimens. 
  • Intracellular Action of a Secreted Peptide Required for Fungal Virulence. 
  • Is there a precursive, relatively procoagulant-inactive form of normal antihemophilic factor (factor VIII)? 
  • Isolation of the domain containing the molybdenum, iron-sulfur I, and iron-sulfur II centers of chicken liver xanthine dehydrogenase. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis. 
  • Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. 
  • Lysosomes and the skin. 
  • Lysosomes and the skin. 
  • Lyticase Facilitates Mycobiome Resolution Without Disrupting Microbiome Fidelity in Primates. 
  • Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth complement by macrophage proteinase. 
  • Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. 
  • Mechanism of action of inter-alpha-trypsin inhibitor. 
  • Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin. 
  • Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Neutral proteinase of rabbit skin: an enzyme capable of degrading skin protein and inducing an inflammatory response. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics. 
  • Oral immunogenicity of the plant proteinase bromelain. 
  • PLASMA ANGIOTENSINASE ACTIVITY IN NORMAL AND TOXEMIC PREGNANCY. 
  • PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo. 
  • Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade. 
  • Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein. 
  • Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. 
  • Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis. 
  • Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. 
  • Probing the stability of native and activated forms of alpha2-macroglobulin. 
  • Production and secretion of proteolytic enzymes by normal and neoplastic cells. 
  • Production of extracellular proteolytic enzymes by neoplastic and normal epithelial cells. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions 
  • Protease-activated quantum dot probes. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Proteases and cystic fibrosis. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. 
  • Proteinases of human epidermis; a possible mechanism for polymorphonuclear leukocyte chemotaxis. 
  • Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration. 
  • Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase. 
  • Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure. 
  • Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. 
  • Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. 
  • Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass. 
  • Regulation of apoptosis resistance and ontogeny of age-dependent diseases. 
  • Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. 
  • Sialic acid prevents loss of large von Willebrand factor multimers by protecting against amino-terminal proteolytic cleavage. 
  • Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. 
  • Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases. 
  • Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 
  • Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. 
  • Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins. 
  • Thrombin generation, inhibition and clinical outcomes in patients with acute myocardial infarction treated with thrombolytic therapy and heparin: results from the GUSTO-I Trial. GUSTO-I Hemostasis Substudy Group. Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries. 
  • Topology of the yeast plasma membrane proton-translocating ATPase. 
  • Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. 
  • Urticaria pigmentosum: nature's experiment in mast cell biology. 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. 
  • Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism. 
  • alpha(2)-Macroglobulin from rheumatoid arthritis synovial fluid: functional analysis defines a role for oxidation in inflammation. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology