Permeability

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  Subject Areas on Research

  • A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. 
  • A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries. 
  • A metamaterial absorber for the terahertz regime: design, fabrication and characterization. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. 
  • Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Asymmetrical electrically induced injury of rabbit ventricular myocytes. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Can glutamine turn off the motor that drives systemic inflammation? 
  • Cellular and molecular biology of the aquaporin water channels. 
  • Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings. 
  • Characteristics of GTP-mediated microsomal Ca2+ release. 
  • Characterization of liposomes containing iodine-125-labeled radiographic contrast agents. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. 
  • Comparative permeability of different glioma models to horseradish peroxidase. 
  • Continuous-flow determination of dialyzable calcium in serum. 
  • Countercurrent multiplication may not explain the axial osmolality gradient in the outer medulla of the rat kidney. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Dabigatran abrogates brain endothelial cell permeability in response to thrombin. 
  • Depression and benign intracranial hypertension. 
  • Depth of water penetration into lipid bilayers. 
  • Development of luminescence procedures to evaluate permeation of multi-ring polyaromatic compounds through protective materials. 
  • Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. 
  • Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response. 
  • Discovery of the aquaporins and development of the field. 
  • Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. 
  • Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy. 
  • E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer. 
  • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. 
  • Effect of AQP1 expression level on Co(2) permeability in bovine corneal endothelium. 
  • Effect of allergic bronchoconstriction on airways epithelial permeability to large polar solutes in the guinea pig. 
  • Effect of fluid shear stress on the permeability of the arterial endothelium. 
  • Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayers. 
  • Effect of tubular inhomogeneities on filter properties of thick ascending limb of Henle's loop. 
  • Effects of colchicine and cytochalasin B on hypertonicity-induced changes in toad urinary bladder. 
  • Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. 
  • Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. 
  • Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. 
  • Factors influencing flux decline during nanofiltration of solutions containing dyes and salts. 
  • Factors influencing nonoxynol-9 permeation and bioactivity in cervical mucus. 
  • Fate of antidiuretic hormone water channel proteins after retrieval from apical membrane. 
  • Feasibility of vitrification as a storage method for tissue-engineered blood vessels. 
  • Flow permeation analysis of bovine cervical mucus. 
  • Fluorescence imaging of blood-brain barrier disruption. 
  • Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. 
  • Functional and structural characterization of endosomes from toad bladder epithelial cells. 
  • Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Glucose recovery with bare and hydrogel-coated microdialysis probes: experiment and simulation of temporal effects. 
  • Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. 
  • Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. 
  • In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. 
  • Incorporation of Cellulose Nanocrystals (CNCs) into the Polyamide Layer of Thin-Film Composite (TFC) Nanofiltration Membranes for Enhanced Separation Performance and Antifouling Properties. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. 
  • Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study. 
  • Investigations into pulsed high-intensity focused ultrasound-enhanced delivery: preliminary evidence for a novel mechanism. 
  • K channel gating by an affinity-switching selectivity filter. 
  • Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. 
  • Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. 
  • Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin 
  • Measurement of endothelial permeability to 125I-low density lipoproteins in rabbit arteries by use of en face preparations. 
  • Mechanistic analysis of electroporation-induced cellular uptake of macromolecules. 
  • Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores. 
  • Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus. 
  • Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold. 
  • Mitochondria in apoptosis and human disease. 
  • Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow. 
  • Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. 
  • Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock. 
  • Peripheral nerve repair with collagen conduits. 
  • Permeability criteria for effective function of passive countercurrent multiplier. 
  • Permeability of four disposable protective-clothing materials to seven antineoplastic drugs. 
  • Permeability of latex and polyvinyl chloride gloves to 20 antineoplastic drugs. 
  • Permeability of latex and polyvinyl chloride gloves to carmustine. 
  • Permeability properties of rat renal lysosomes. 
  • Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans. 
  • Quantum-dot-decorated robust transductable bioluminescent nanocapsules 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Release of cytochrome c from liver mitochondria during permeability transition. 
  • Remobilization of residual non-aqueous phase liquid in porous media by freeze-thaw cycles. 
  • Robotically handled whole-tissue culture system for the screening of oral drug formulations. 
  • Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. 
  • Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay. 
  • Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177). 
  • Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407. 
  • Solubility of carbon dioxide in lipid bilayer membranes and organic solvents. 
  • Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • The dielectric constant of phospholipid bilayers and the permeability of membranes to ions. 
  • The permeability of the outer layers of limbus and anterior sclera. 
  • The role of blood-brain barrier permeability in brain tumor imaging and therapeutics. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs. 
  • Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. 
  • Urine concentrating mechanism in the inner medulla: function of the thin limbs of Henle’s loops 
  • Use of liposomes as carriers for radiation synovectomy. 
  • Vagal nerve stimulation modulates gut injury and lung permeability in trauma-hemorrhagic shock. 
  • Water movement during apoptosis: a role for aquaporins in the apoptotic volume decrease (AVD). 
  • Water permeability and mechanical strength of polyunsaturated lipid bilayers. 
  • Water permeability of an ovarian antral follicle is predominantly transcellular and mediated by aquaporins. 
  • Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. 
  • Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering