Peutz-Jeghers Syndrome

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  Subject Areas on Research

  • Acute abdominal pain due to intussusception of the small intestine in a 17-year-old patient. 
  • Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. 
  • Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. 
  • Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. 
  • Morphologic characterization of syndromic gastric polyps. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Peutz-Jeghers syndrome: are "shaggy" villi part of the pathology? 
  • Report of a case combining solitary Peutz-Jeghers polyp, colitis cystica profunda, and high-grade dysplasia of the epithelium of the colon. 
  • Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome. 
  • mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.