Phagocytosis

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  Subject Areas on Research

  • "Cannibalistic" phagocytosis in acute megakaryoblastic leukemia (AML M7) with t(10;17)(p15;q22). 
  • A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. 
  • Abnormalities of leukocyte chemotaxis in human disease. 
  • Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. 
  • Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. 
  • Acute toxicity of lead particulates on pulmonary alveolar macrophages. Ultrastructural and microanalytical studies. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Alterations in reticulo-endothelial functions as produced by the administration of bacterial toxins. 
  • Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. 
  • Antibody-DEPENDENT, FcγRI-mediated neutralization of HIV-1 in TZM-bl cells occurs independently of phagocytosis. 
  • Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. 
  • Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia. 
  • Asbestos body phagocytosis by human free alveolar macrophages. 
  • Aspiration of the asymptomatic metatarsophalangeal joint in gout patients and hyperuricemic controls. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Beyond Viral Neutralization. 
  • Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. 
  • Biology of vascular calcification in renal disease. 
  • CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. 
  • CD47 regulates the phagocytic clearance and replication of the Plasmodium yoelii malaria parasite. 
  • CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork. 
  • Chemotaxis of inflammatory cells. 
  • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Combined Atomic Force Microscope and Volumetric Light Sheet System for Correlative Force and Fluorescence Mechanobiology Studies. 
  • Comparative studies of erythrophagocytosis in the rabbit and human vitreous. 
  • Comparison of phagocytosis of uncoated versus coated asbestos fibers by cultured human pulmonary alveolar macrophages. 
  • Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis. 
  • Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. 
  • Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcosis: a model for the understanding of infectious diseases. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. 
  • Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. 
  • Disorders of leukocyte chemotaxis. 
  • Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors. 
  • Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. 
  • Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction. 
  • Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects. 
  • Does IVIg administration yield improved immune function in very premature neonates? 
  • EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 
  • Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. 
  • Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. 
  • Erythrocyte phagocytosis in the human trabecular meshwork. 
  • Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia. 
  • Erythrophagocytosis in Gaucher cells. 
  • Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion. 
  • Evaluation of a cytocentrifuge method for measuring neutrophil granulocyte chemotaxis. 
  • Fatal Rocky Mountain spotted fever. Hematologic and lymphoreticular observations. 
  • Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial. 
  • Fimbriae-mediated host-pathogen cross-talk. 
  • Function of microglia in organotypic slice cultures. 
  • Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Functional and anatomic correlation of splenic regeneration following embolization. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Further observations on the process of haemophagocytosis in the human outflow system. 
  • GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. 
  • Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines. 
  • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. 
  • HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. 
  • Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies. 
  • Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. 
  • Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. 
  • Immune function during intravenous administration of a soybean oil emulsion. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VI. Augmentation of antibody-dependent killing following quantitative and qualitative changes in host peritoneal cells. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • In vitro function of indium-111 oxine-labeled human monocytes. 
  • In vitro phagocytosis and intracellular fate of variously encapsulated strains of Cryptococcus neoformans. 
  • Induction of anti-myelin antibodies in EAE and their possible role in demyelination. 
  • Induction of apoptosis in circulating angiogenic cells by microparticles. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Infection of artificial air pouches in the connective tissue of mice with Neisseria gonorrhoeae. 
  • Inflammation and Infection in Pain and the Role of GPR37. 
  • Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. 
  • Intravascular coagulation--a source of possible error in carbon-clearance determinations. 
  • Killing of Cryptococcus neoformans by rat alveolar macrophages. 
  • Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. 
  • Kindlin-3 gives patrolling monocytes a strong grip. 
  • Leptin regulates proinflammatory immune responses. 
  • Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. 
  • Lysosomes and the skin. 
  • Lysosomes and the skin. 
  • M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1. 
  • MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. 
  • Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. 
  • Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases. 
  • Macrophage migratory dysfunction in cancer. A mechanism for subversion of surveillance. 
  • Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate. 
  • Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Macrophages and infertility: enhancement of human macrophage-mediated sperm killing by antisperm antibodies. 
  • Macrophages and infertility: oviductal macrophages as potential mediators of infertility. 
  • Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell phagocytosis of FimH-expressing enterobacteria. 
  • Mast cells and basophils in innate immunity. 
  • Mast cells as modulators of host defense in the lung. 
  • Mast cells in infection and immunity. 
  • Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. 
  • Mechanism of the luminol-dependent chemiluminescence of human neutrophils. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors. 
  • MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Microglia Sculpt Sex Differences in Social Behavior. 
  • Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma. 
  • Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1. 
  • Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. 
  • Neuroinflammation in Alzheimer's disease. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • Neuronal vulnerability and multilineage diversity in multiple sclerosis. 
  • Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles. 
  • Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. 
  • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. 
  • Non-erythroid effects of erythropoietin. 
  • Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure. 
  • Normal neutrophil function in cathepsin G-deficient mice. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. 
  • Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. 
  • Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum. 
  • Phagocytosis of Cryptococcus neoformans by rat alveolar macrophages. 
  • Phenotypic characterization of gamma interferon-induced human monocyte polykaryons. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Physiological mechanisms contributing to increased interleukin-1 secretion. 
  • Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. 
  • Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers. 
  • Production of superoxide anion by an NADPH-oxidase from rat pulmonary macrophages. 
  • Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide. 
  • Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles. 
  • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. 
  • Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 
  • Recombinant Pseudomonas Bionanoparticles Induce Protection against Pneumonic Pseudomonas aeruginosa Infection. 
  • Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. 
  • Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. 
  • Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. 
  • Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome. 
  • Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. 
  • Retinitis pigmentosa: clinical management based on current concepts. 
  • Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. 
  • Role of transmethylation reactions in cellular motility and phagocytosis. 
  • Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV. 
  • Scanning electron microscopic examination of human asbestos bodies. 
  • Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Sex differences in microglial appetites during development: Inferences and implications. 
  • Signal transduction in cells following binding of chemoattractants to membrane receptors. 
  • Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers. 
  • Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis. 
  • Sperm-macrophage interaction in the mouse: a quantitative assay in vitro using 111indium oxine-labeled sperm. 
  • Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Stress response of the trabecular meshwork. 
  • Studies on cellular autophagocytosis. A histochemical study on sequential alterations of mitochondria in the glucagon-induced autophagic vacuoles of rat liver. 
  • Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. 
  • Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro. 
  • Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. 
  • Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic. 
  • Systemic lupus erythematosus: a matter of life and death. 
  • Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation. 
  • Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study. 
  • The Effects of 16 Weeks of Exercise Training on Neutrophil Functions in Breast Cancer Survivors. 
  • The Trojan Horse of the microbiological arms race: phage-encoded toxins as a defence against eukaryotic predators. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The monocyte monolayer assay: a noninvasive technique for predicting the severity of in utero hemolysis. 
  • The release of microparticles by apoptotic cells and their effects on macrophages. 
  • The role of HMGB1 in efferocytosis: when the dead go unburied. Focus on "HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin". 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The structure of mononuclear phagocytes differentiating in vivo. III. The effect of particulate foreign substances. 
  • The use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous bone marrow transplantation. 
  • Transport of lysosomes decreases in the perinuclear region: Insights from changepoint analysis. 
  • Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis. 
  • Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity. 
  • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. 
  • Virus Control in Vaccinated Rhesus Macaques Is Associated with Neutralizing and Capturing Antibodies against the SHIV Challenge Virus but Not with V1V2 Vaccine-Induced Anti-V2 Antibodies Alone. 
  • Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis. 
  • Yeast-like organisms phagocytosed by circulating neutrophils: Evidence of disseminated histoplasmosis. 
  • [Metabolic changes in human leukocytes during phagocytosis]. 
  • [THE ENZYMES OF THE LEUKOCYTE]. 
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  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Shinohara, Mari L., Associate Professor of Immunology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Immunology