Phagocytosis

• 

  Subject Areas on Research

  • "Cannibalistic" phagocytosis in acute megakaryoblastic leukemia (AML M7) with t(10;17)(p15;q22). 
  • A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. 
  • A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia. 
  • A quantitative fluorescent method for measurement of bacterial adherence and phagocytosis. 
  • AML-loaded DC generate Th1-type cellular immune responses in vitro. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Abnormalities of leukocyte chemotaxis in human disease. 
  • Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. 
  • Activation of the C3b receptor: effect of diacylglycerols and calcium mobilization. 
  • Activity and activation of the granulocyte superoxide-generating system. 
  • Acute toxicity of lead particulates on pulmonary alveolar macrophages. Ultrastructural and microanalytical studies. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Alterations in reticulo-endothelial functions as produced by the administration of bacterial toxins. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. 
  • Annihilating host defense. 
  • Antibody-DEPENDENT, FcγRI-mediated neutralization of HIV-1 in TZM-bl cells occurs independently of phagocytosis. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Availability of complement bound to Staphylococcus aureus to interact with membrane complement receptors influences efficiency of phagocytosis. 
  • Bacillus anthracis spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Bactericidal and opsonic properties of C4-deficient guinea pig serum. 
  • Beyond Viral Neutralization. 
  • Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. 
  • C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. 
  • C1q enhances the phagocytosis of Cryptococcus neoformans blastospores by human monocytes. 
  • C3d receptors are expressed on human monocytes after in vitro cultivation. 
  • CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. 
  • CR1-receptor recycling in phorbol ester-activated polymorphonuclear leucocytes. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Chemotaxis of inflammatory cells. 
  • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Complement and bacteria: chemistry and biology in host defense. 
  • Complement receptors and histamine degradation. 
  • Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcosis: a model for the understanding of infectious diseases. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Defensins impair phagocytic killing by neutrophils in biomaterial-related infection. 
  • Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. 
  • Disorders of leukocyte chemotaxis. 
  • Disorders of respiratory burst termination. 
  • Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. 
  • Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line. 
  • Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction. 
  • Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects. 
  • Does IVIg administration yield improved immune function in very premature neonates? 
  • EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils. 
  • Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes. 
  • Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. 
  • Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia. 
  • Erythrophagocytosis in Gaucher cells. 
  • Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion. 
  • Evaluation of a cytocentrifuge method for measuring neutrophil granulocyte chemotaxis. 
  • Fatal Rocky Mountain spotted fever. Hematologic and lymphoreticular observations. 
  • Fimbriae-mediated host-pathogen cross-talk. 
  • Function of microglia in organotypic slice cultures. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Functional and anatomic correlation of splenic regeneration following embolization. 
  • Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. 
  • HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. 
  • Human eosinophil adherence to serum-treated sepharose: granule-associated enzyme release and requirement for activation of the alternative complement pathway. 
  • Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. 
  • Immune function during intravenous administration of a soybean oil emulsion. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VI. Augmentation of antibody-dependent killing following quantitative and qualitative changes in host peritoneal cells. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • In vitro function of indium-111 oxine-labeled human monocytes. 
  • In vitro phagocytosis and intracellular fate of variously encapsulated strains of Cryptococcus neoformans. 
  • Increased sensitivity to H2O2 in glutathione peroxidase-deficient rat granulocytes. 
  • Induction of anti-myelin antibodies in EAE and their possible role in demyelination. 
  • Induction of apoptosis in circulating angiogenic cells by microparticles. 
  • Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Infection of artificial air pouches in the connective tissue of mice with Neisseria gonorrhoeae. 
  • Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Interaction of Neisseria gonorrhoeae with classical complement components, C1-inhibitor, and a monoclonal antibody directed against the Neisserial H.8 antigen. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. 
  • Killing of Cryptococcus neoformans by rat alveolar macrophages. 
  • Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. 
  • Leptin regulates proinflammatory immune responses. 
  • Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. 
  • Lysosomes and the skin. 
  • Lysosomes and the skin. 
  • MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. 
  • Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases. 
  • Macrophage migratory dysfunction in cancer. A mechanism for subversion of surveillance. 
  • Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate. 
  • Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Macrophages and infertility: enhancement of human macrophage-mediated sperm killing by antisperm antibodies. 
  • Macrophages and infertility: oviductal macrophages as potential mediators of infertility. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell phagocytosis of FimH-expressing enterobacteria. 
  • Mast cells and basophils in innate immunity. 
  • Mast cells as modulators of host defense in the lung. 
  • Mast cells in infection and immunity. 
  • Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors. 
  • MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function. 
  • Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of rapamycin inhibition. 
  • NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes. 
  • Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. 
  • Neuroinflammation in Alzheimer's disease. 
  • Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. 
  • New developments in immunopathology with special reference to complement and immune complexes. 
  • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. 
  • Non-erythroid effects of erythropoietin. 
  • Normal neutrophil function in cathepsin G-deficient mice. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. 
  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. 
  • Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. 
  • Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum. 
  • Phagocytosis of Cryptococcus neoformans by rat alveolar macrophages. 
  • Phagocytosis of target particles bearing C3b-IgG covalent complexes by human monocytes and polymorphonuclear leucocytes. 
  • Phenotypic characterization of gamma interferon-induced human monocyte polykaryons. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Physiological mechanisms contributing to increased interleukin-1 secretion. 
  • Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. 
  • Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. 
  • Production of superoxide anion by an NADPH-oxidase from rat pulmonary macrophages. 
  • Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide. 
  • Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. 
  • Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. 
  • Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. 
  • Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome. 
  • Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. 
  • Reticuloendothelial clearance of radiolabelled pneumococci in experimental bacteremia: correlation of changes in clearance rates, sequestration patterns, and opsonization requirements at different phases of the bacterial growth cycle. 
  • Retinitis pigmentosa: clinical management based on current concepts. 
  • Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. 
  • Role of transmethylation reactions in cellular motility and phagocytosis. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Signal transduction in cells following binding of chemoattractants to membrane receptors. 
  • Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis. 
  • Sperm-macrophage interaction in the mouse: a quantitative assay in vitro using 111indium oxine-labeled sperm. 
  • Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Stress response of the trabecular meshwork. 
  • Structural and functional properties of the "hairy" cells of leukemic reticuloendotheliosis. 
  • Studies of phagocytosis in chronic granulomatous disease. 
  • Studies on cellular autophagocytosis. A histochemical study on sequential alterations of mitochondria in the glucagon-induced autophagic vacuoles of rat liver. 
  • Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. 
  • Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro. 
  • Studies on phagocytosis in patients with acute bacterial infections. 
  • Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization. 
  • Superoxide production by digitonin-stimulated guinea pig granulocytes. The effects of N-ethyl maleimide, divalent cations; and glycolytic and mitochondrial inhibitors on the activation of the superoxide generating system. 
  • Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia. 
  • Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. 
  • Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic. 
  • Systemic lupus erythematosus: a matter of life and death. 
  • Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. 
  • The complement fragment C3d facilitates phagocytosis by monocytes. 
  • The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor necrosis factor. 
  • The effects of intravenous immune globulin on complement-dependent immune damage of cells and tissues. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The monocyte monolayer assay: a noninvasive technique for predicting the severity of in utero hemolysis. 
  • The nature of allergy. 
  • The release of microparticles by apoptotic cells and their effects on macrophages. 
  • The reticuloendothelial system and autoimmune disease in man. 
  • The role of HMGB1 in efferocytosis: when the dead go unburied. Focus on "HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin". 
  • The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream. 
  • The role of complement in inflammation and phagocytosis. 
  • The role of glutathione reductase in maintaining human granulocyte function and sensitivity to exogenous H2O2. 
  • The role of late complement components and the alternate complement pathway in experimental cryptococcosis. 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. 
  • The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The structure of mononuclear phagocytes differentiating in vivo. III. The effect of particulate foreign substances. 
  • The use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous bone marrow transplantation. 
  • Transcription factor p53 influences microglial activation phenotype. 
  • Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism. 
  • Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. 
  • [Metabolic changes in human leukocytes during phagocytosis]. 
  • [THE ENZYMES OF THE LEUKOCYTE]. 
• 

  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Sanchez-Perez, Luis Ariel, Assistant Professor of Neurosurgery, Neurosurgery
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology