Phagosomes

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  Subject Areas on Research

  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. 
  • Bi-modal regulation of a formin by srGAP2. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Characterization of lung inflammation and its impact on macrophage function in aging. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons. 
  • Dengue virus and autophagy. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1. 
  • Macrophage activation downregulates the degradative capacity of the phagosome. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth. 
  • Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. 
  • Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
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  Keywords of People

  • Taylor, Gregory Alan, Professor in Medicine, Immunology