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Subject Areas on Research
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A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
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A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).
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A framework to evaluate the economic impact of pharmacogenomics.
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A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
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A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.
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A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.
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A hub for bench-to-bedside pharmacogenomic-based research.
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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
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A penalized likelihood approach for investigating gene-drug interactions in pharmacogenetic studies.
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A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials.
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A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.
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A pharmacogenetic versus a clinical algorithm for warfarin dosing.
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A rationale for conducting parallel mechanistic studies in clinical trials of pharmacotherapy.
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A recent update of pharmacogenomics in drug-induced severe skin reactions.
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A stepwise approach to implementing pharmacogenetic testing in the primary care setting.
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ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.
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Adding pharmacogenetics information to drug labels: lessons learned.
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Advances in pharmacogenomic research and development.
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Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.
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Anesthesia: a discipline that incorporates clinical pharmacology across the DDRU continuum.
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Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
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Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.
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Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
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Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study.
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Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment.
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Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort.
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Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
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Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.
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Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients.
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Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
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Biomarkers for smoking cessation.
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Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial.
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Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure.
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CYP2C19 pharmacogenetics versus standard of care dosing for selecting antiplatelet therapy in patients with coronary artery disease: A meta-analysis of randomized clinical trials.
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CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.
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CYP3A4/5 and pharmacogenetics in patients with sarcoma - Authors' reply.
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Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.
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Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.
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Challenges to integrating pharmacogenetic testing into medication therapy management.
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Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
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Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
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Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
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Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing.
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Clinical Utilization of Pharmacogenetics in Psychiatry - Perspectives of Pharmacists, Genetic Counselors, Implementation Science, Clinicians, and Industry.
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Clinical application of cardiovascular pharmacogenetics.
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Clinical application of pharmacogenetics: focusing on practical issues.
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Clinical delivery of pharmacogenetic testing services: a proposed partnership between genetic counselors and pharmacists.
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Clinical interpretation and implications of whole-genome sequencing.
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Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
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Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms.
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Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
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Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.
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Community pharmacists' experience with pharmacogenetic testing.
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Comparison of delivery strategies for pharmacogenetic testing services.
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Connecting genetic risk to disease end points through the human blood plasma proteome.
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Consensus statement on transcultural issues in depression and anxiety from the International Consensus Group on Depression and Anxiety.
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Consideration of patient preferences and challenges in storage and access of pharmacogenetic test results.
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Considerations of pharmacogenetic testing in children.
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Cost-effectiveness of epidermal growth factor receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma of the lung.
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Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study.
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Delivering pharmacogenetic testing to the masses: an achievable goal?
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Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.
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Development of biomarkers to optimize pediatric patient management: what makes children different?
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Developmental pharmacogenomics.
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Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents.
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Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.
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Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease.
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Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
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Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response.
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Economic analysis of gene expression profile data to guide adjuvant treatment in women with early-stage breast cancer.
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Educating patients and providers through comprehensive pharmacogenetic test reports.
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Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.
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Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute myocardial infarction survivors treated with clopidogrel and aspirin.
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Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial.
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Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.
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Efficacy of the pharmacologic chaperone migalastat in a subset of male patients with the classic phenotype of Fabry disease and migalastat-amenable variants: data from the phase 3 randomized, multicenter, double-blind clinical trial and extension study.
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Enteric microbiome metabolites correlate with response to simvastatin treatment.
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Estimation of the warfarin dose with clinical and pharmacogenetic data.
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Evaluation of a pharmacogenetic educational toolkit for community pharmacists.
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Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays.
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Exploratory planning and implementation of a pilot pharmacogenetic program in a community pharmacy.
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Factors influencing uptake of pharmacogenetic testing in a diverse patient population.
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Future directions in pharmacogenomics discovery in cardiovascular disease.
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Gastric cancer pharmacogenetics: progress or old tripe?
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Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
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Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.
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Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer.
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Genetic and social environment interactions and their impact on health policy.
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Genetic lesions in diffuse large B-cell lymphomas.
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Genetic markers of suicidal ideation emerging during citalopram treatment of major depression.
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Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.
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Genetic profiling and tailored therapy in asthma: are we there yet?
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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
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Genetics in heart failure: practical incorporation of this new biologic dimension.
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Genetics. FDA races in wrong direction.
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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
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Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
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Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
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Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium.
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Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.
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Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
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Genomic and personalized medicine: foundations and applications.
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Genomic medicine: a decade of successes, challenges, and opportunities.
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Genomic medicine: bringing biomarkers to clinical medicine.
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Genomic signatures to guide the use of chemotherapeutics.
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Grassroots marketing in a global era: more lessons from BiDil.
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Horizon Scan Of Clinical Laboratories Offering Pharmacogenetic Testing.
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Human leukocyte antigens and drug hypersensitivity.
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Identifying genomic and developmental causes of adverse drug reactions in children.
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Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction.
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Implementation of a pharmacogenomics service in a community pharmacy.
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Implementing genome-driven personalized cardiology in clinical practice.
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Implications of pharmacogenomics for drug development and clinical practice.
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Incorporation of pharmacogenetic testing into medication therapy management.
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Individualizing pharmacogenomic test results in the context of the microbiome.
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Influence of CYP2C19*2 and *3 loss-of-function alleles on the pharmacodynamic effects of standard- and high-dose clopidogrel in East Asians undergoing percutaneous coronary intervention: the results of the ACCEL-DOUBLE-2N3 study.
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Influence of genetic polymorphisms on platelet function, response to antiplatelet drugs and clinical outcomes in patients with coronary artery disease.
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Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care.
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Integration of pharmacometabolomic and pharmacogenomic approaches reveals novel insights into antiplatelet therapy.
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Is genetic testing for cytochrome P450 polymorphisms ready for implementation?
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Is primary care ready for pharmacogenetics?
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Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.
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Learning from product labels and label changes: how to build pharmacogenomics into drug-development programs.
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Managing Increased Accessibility to Pharmacogenomic Data.
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Medical genomics: Gather and use genetic data in health care.
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Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
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Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine.
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Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.
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Methadone pharmacogenetics in vitro and in vivo: Metabolism by CYP2B6 polymorphic variants and genetic variability in paediatric disposition.
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MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.
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Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
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Mutations linked to drug resistance, human immunodeficiency virus type 1 biologic phenotype and their association with disease progression in children receiving nucleoside reverse transcriptase inhibitors.
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New applications of disease genetics and pharmacogenetics to drug development.
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New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.
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North Carolina's multi-institutional pharmacogenomics efforts with the North Carolina Precision Health Collaborative.
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Nurses' communication of pharmacogenetic test results as part of discharge care.
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O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
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On assessing bioequivalence using genomic data with model misspecification.
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies.
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Optimization of pediatric rheumatology therapeutics.
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Pancreatic cancer: translating lessons from mouse models.
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Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance).
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Patient characteristics, experiences and perceived value of pharmacogenetic testing from a single testing laboratory.
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Personalized medicine: progress and promise.
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Personalized medicine: revolutionizing drug discovery and patient care.
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Pharmacogenetic challenges for the health care system.
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Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.
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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
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Pharmacogenetic testing in the face of unclear clinical efficacy: lessons from cytochrome P450 2D6 for tamoxifen.
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Pharmacogenetic testing: not as simple as it seems.
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Pharmacogenetics and safety parameters for platelet P2Y12 receptor antagonists.
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Pharmacogenetics goes 3D.
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Pharmacogenetics in heart failure trials.
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Pharmacogenetics of Clopidogrel: An Unresolved Issue.
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Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
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Pharmacogenetics of methylphenidate response in preschoolers with ADHD.
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Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.
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Pharmacogenetics studies in STAR*D: strengths, limitations, and results.
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Pharmacogenetics: Ethical Issues and Policy Options
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Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.
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Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.
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Pharmacogenomics courses in pharmacy school curricula.
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Pharmacogenomics for personalized pain medicine.
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Pharmacogenomics in cancer therapy: is host genome variability important?
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Pharmacogenomics in childhood rheumatic disorders: a foundation for future individualized therapy.
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Pharmacogenomics in pediatric rheumatology.
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Pharmacogenomics in the nursing literature: an integrative review.
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Pharmacogenomics of Bucindolol in Atrial Fibrillation and Heart Failure.
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Pharmacogenomics of adverse drug reactions: implementing personalized medicine.
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Pharmacogenomics of β-blockers and statins: possible implications for perioperative cardiac complications.
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Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.
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Pharmacometabolomics reveals racial differences in response to atenolol treatment.
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Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting.
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Pipeline pharmacogenetics: a novel approach to integrating pharmaco-genetics into drug development.
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Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma.
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Potential applications of pharmacogenomics to heart failure therapies.
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Potential use of auxiliary labels to promote patient awareness of pharmacogenetic testing.
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Practical ethics: establishing a pathway to benefit for complex pharmacogenomic tests.
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Precision Medicine: Towards Individualized Dosing in Pediatric Rheumatology.
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Precision medicine in addiction research: where has the time gone?
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Predictors of consent to pharmacogenomics testing in the IDEAL study.
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Primary care physicians' knowledge of and experience with pharmacogenetic testing.
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Professional perspectives about pharmacogenetic testing and managing ancillary findings.
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Proposal for a pharmacogenetics certificate program for pharmacists.
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Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype.
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Prospects for personalized cardiovascular medicine: the impact of genomics.
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Public attitudes toward ancillary information revealed by pharmacogenetic testing under limited information conditions.
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Public perspectives about pharmacogenetic testing and managing ancillary findings.
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Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.
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Recent developments in clopidogrel pharmacology and their relation to clinical outcomes.
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Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
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Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
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Role of genotype-based personalized antiplatelet therapy in the era of potent P2Y₁₂ receptor inhibitors.
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Sleep Pharmacogenetics: The Promise of Precision Medicine.
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Some aspects of analysis of gene array data.
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Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.
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Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.
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Stevens-Johnson syndrome induced by the cross-reactivity between teicoplanin and vancomycin.
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Striking a balance in communicating pharmacogenetic test results: promoting comprehension and minimizing adverse psychological and behavioral response.
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Survey of US public attitudes toward pharmacogenetic testing.
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Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing.
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Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer.
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TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics.
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Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
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Targeted therapies for cancer 2004.
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Testing gene-treatment interactions in pharmacogenetic studies.
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
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The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.
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The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.
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The Personalized Medicine Coalition: goals and strategies.
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The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.
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The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
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The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.
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The convergence of herb pharmacodynamics and herb-drug interactions on hemostasis.
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The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients.
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The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
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The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.
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The influence of CYP2C19 polymorphisms on the pharmacokinetics, pharmacodynamics, and clinical effectiveness of P2Y(12) inhibitors.
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The integration of molecular diagnostics with therapeutics. Implications for drug development and pathology practice.
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The long and winding road to warfarin pharmacogenetic testing.
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The path to personalized medicine.
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The pharmacogenetics of antiplatelet agents: towards personalized therapy?
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The pharmacogenetics of coumarin therapy.
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The potential impact of pharmacogenetic testing on medication adherence.
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The potential of a placebo/nocebo effect in pharmacogenetics.
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The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
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The use of single-nucleotide polymorphism maps in pharmacogenomics.
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The worry about clopidogrel "nonresponsiveness": identification and treatment in the post-percutaneous coronary intervention patient.
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Toward a Definition of "No Meaningful Benefit" From Antidepressant Treatment: An Equipercentile Analysis With Cross-Trial Validation Across Multiple Rating Scales.
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Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.
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Translating genomic biomarkers into clinically useful diagnostics.
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Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system.
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United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.
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Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease.
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Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.
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Use of pharmacogenetics to guide warfarin therapy.
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Using Stepwise Pharmacogenomics and Proteomics to Predict Hepatitis C Treatment Response in Difficult to Treat Patient Populations.
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Using pharmacogenetics to improve drug safety and efficacy.
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VKORC1 haplotypes in five East-Asian populations and Indians.
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What is the role of pharmacogenetics in clinical psychiatry?
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Where the rubber meets the road in pharmacogenetics: assessment of gene-environment interactions.
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Keywords of People
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Allen LaPointe, Nancy Marie,
Adjunct Associate Professor in the Department of Medicine,
Medicine, Cardiology
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Cho, Alex Han,
Associate Professor of Medicine,
Medicine, General Internal Medicine
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James, Michael Lucas,
Professor of Anesthesiology,
Anesthesiology
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Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
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O'Connor, Christopher Michael,
Adjunct Professor in the Department of Medicine,
Medicine, Clinical Pharmacology
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Orlando, Lori Ann,
Professor of Medicine,
Medicine, General Internal Medicine
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Voora, Deepak,
Associate Professor of Medicine,
Medicine, Cardiology