Phenylephrine

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  Subject Areas on Research

  • A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. 
  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. 
  • A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. 
  • A survey of the management of spinal-induced hypotension for scheduled cesarean delivery. 
  • Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels. 
  • Alpha 1-adrenoceptor activity in arterial smooth muscle following congestive heart failure. 
  • Assessment of the Frank-Starling relationship by two-dimensional echocardiography. 
  • Baroreflex regulation of regional blood flow in congestive heart failure. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Calcium ion fluxes induced by the action of alpha-adrenergic agonists in perfused rat liver. 
  • Cardiac output by impedance cardiography: two alternative methodologies compared with thermodilution. 
  • Cell-free hemoglobin reverses the endotoxin-mediated hyporesponsivity of rat aortic rings to alpha-adrenergic agents. 
  • Cryosurgical denervation of the heart: acute and chronic effects. 
  • Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. 
  • Defining end systole for end-systolic pressure-volume ratio. 
  • Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis. 
  • Diabetic urethropathy compounds the effects of diabetic cystopathy. 
  • Effect of pharmacologic increases in afterload on left ventricular rotation and strain in a rabbit model. 
  • Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction. 
  • Effects of arterial hypertension on myocardial recovery after ischemic injury. 
  • Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion. 
  • Endothelium-dependent relaxations in canine coronary arteries are enhanced in early heart failure and persist in recovery. 
  • Ethacrynic acid: acute hemodynamic effects and influence on the in vivo and in vitro response to nitroglycerin in the dog. 
  • Evaluation of several methods for computing stroke volume from central aortic pressure. 
  • Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction. 
  • Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro. 
  • Hemodynamic impact of dexmedetomidine administration in 15,656 noncardiac surgical cases. 
  • Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. 
  • Hostility, social support, and adrenergic receptor responsiveness among African-American and white men and women. 
  • Human Vascular Microphysiological System for in vitro Drug Screening. 
  • Hypothermia: role of alpha 1- and alpha 2-noradrenergic receptors in the hypothalamus of the cat. 
  • Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults. 
  • Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting. 
  • Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Intrahepatic glucose: a requirement for neonatal ODC induction by specific hormones. 
  • Intraoperative hypoxemic spells in tetralogy of Fallot. An echocardiographic analysis of diagnosis and treatment. 
  • Intraoperative management of penile erection with intracorporeal phenylephrine during endoscopic surgery. 
  • Investigations into the role of sulfhydryl groups in the mechanism of action of the nitrates. 
  • Is routine pupil dilation safe among asian patients with diabetes? 
  • Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. 
  • Means for load variation during echocardiographic assessment of the Frank-Starling relationship. 
  • Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation. 
  • Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. 
  • Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. 
  • Noninvasive assessment of baroreflex control in borderline hypertension. Comparison with the phenylephrine method. 
  • Ocular oxygenation: the effect of phenylephrine on anterior chamber oxygen tension. 
  • Phenylephrine induces delayed cardioprotection against necrosis without amelioration of stunning. 
  • Phenylephrine infusion impact on surgical site infections after lower extremity bypass surgery. 
  • Phenylephrine versus ephedrine for the management of hypotension in the obstetric patient; do we have an updated answer? 
  • Phenylephrine-induced anterior chamber hypoxia. 
  • Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography. 
  • Prolonged Cardiac Dysfunction After Intraparenchymal Hemorrhage and Neurogenic Stunned Myocardium. 
  • Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure. 
  • Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure. 
  • Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. 
  • Respiratory effects of pressor and depressor agents in conscious rats. 
  • Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men. 
  • Retrospective comparison of ephedrine and phenylephrine for the treatment of spinal anesthesia induced hypotension in pre-eclamptic patients. 
  • S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. 
  • Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. 
  • Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors. 
  • Shunt dynamics in experimental atrial septal defects. 
  • Specific PGF(2alpha) receptor (FP) antagonism and human uterine contractility in vitro. 
  • Spinal-induced hypotension: Incidence, mechanisms, prophylaxis, and management: Summarizing 20 years of research. 
  • Stimulation by alpha-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • The action of alpha-adrenergic agonists on plasma-membrane calcium fluxes in perfused rat liver. 
  • The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver. 
  • The effect of ionophore A23187 on calcium ion fluxes and alpha-adrenergic-agonist action in perfused rat liver. 
  • The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts. 
  • The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps. 
  • The prosurvival protein BAG3: a new participant in vascular homeostasis. 
  • The role of sinoaortic and cardiopulmonary baroreceptor reflex arcs in nociception and stress-induced analgesia. 
  • Toxic effects of catecholamines on skin. 
  • Up-down determination of the 90% effective dose of phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery. 
  • Vascular smooth muscle responsiveness to noradrenaline and phenylephrine following experimental heart failure in dogs. 
  • Ventilatory effects of angiotensin and vasopressin in conscious rats. 
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  Keywords of People

  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology