Phosphatidylcholines

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  Subject Areas on Research

  • "Prediction is very hard, especially about the future": new biomarkers for type 2 diabetes? 
  • 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway. 
  • A calorimetric and monolayer investigation of the influence of ions on the thermodynamic properties of phosphatidylcholine. 
  • A new helper phospholipid for gene delivery. 
  • A new monofluorinated phosphatidylcholine forms interdigitated bilayers. 
  • A novel micropipet method for measuring the bending modulus of vesicle membranes. 
  • A nuclear magnetic resonance study of the interaction of L-epinephrine with phospholipid vesicles. 
  • A synthetic lecithin containing branched-chain fatty acids: physical properties and membrane studies. 
  • A thermodynamic study of the partition of n-hexane into phosphatidylcholine and phosphatidylcholine-cholesterol bilayers. 
  • Abnormal lipid composition of the red cell membrane in congenital dyserythropoietic anemia type II (HEMPAS). 
  • Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants. 
  • Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study. 
  • Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. 
  • An electron spin resonance study of cholestane spin label in aqueous mixtures of biliary lipids. 
  • Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. 
  • Application of the temperature-jump technique to the study of phospholipid dispersions. 
  • Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation. 
  • Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion. 
  • Bombesin increases fetal lung growth and maturation in utero and in organ culture. 
  • Bombesin-like peptide and receptors in lung injury models: diverse gene expression, similar function. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • Calcium binding by monosulfate esters of taurochenodeoxycholate. 
  • Can regular solution theory be applied to lipid bilayer membranes? 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan. 
  • Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. 
  • Cholesterol modifies the short-range repulsive interactions between phosphatidylcholine membranes. 
  • Chromogenic assay for phospholipase C from Bacillus cereus. 
  • Comparative incorporation of P32 into lung phosphatidyl choline in mammals with different metabolic and pulmonary morphologic characteristics. 
  • Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients. 
  • Contributions of hydration and steric (entropic) pressures to the interactions between phosphatidylcholine bilayers: experiments with the subgel phase. 
  • Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. 
  • Correlated x-ray diffraction and freeze-fracture studies on membrane model systems. Perturbations induced by freeze-fracture preparative procedures. 
  • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • DIACYLGLYCEROL ACYLTRANSFERASE1 Contributes to Freezing Tolerance. 
  • Determination of the depth of bromine atoms in bilayers formed from bromolipid probes. 
  • Direct electrochemistry of hemoglobin in egg-phosphatidylcholine films and its catalysis to H(2)O(2). 
  • Dual-wavelength ratiometric fluorescence measurement of the membrane dipole potential. 
  • Effect of chain length and unsaturation on elasticity of lipid bilayers. 
  • Effect of gamma irradiation and cystamine on kidney lipids of rats. 
  • Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat. 
  • Effect of retinol and retinoic acid on liver lipids of rats fed different levels of protein. 
  • Effect of retinol on the molecular species of hepatic phosphatidyl choline in young rats. 
  • Effect of whole body gamma irradiation on fatty acid composition of liver lipids of female rats and radioprotection by cystamine. 
  • Effects of phenylamide herbicides on the physical properties of phosphatidylcholine membranes. 
  • Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats. 
  • Efficacy of provitamin A carotenoids in reversing vitamin A deficiency induced lesions in brain lipids of chicks. 
  • Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility. 
  • Electrostatic control of phospholipid polymorphism. 
  • Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. 
  • Evaluation of biosynthetic pathways of phosphatidyl choline in liver of rats given phenobarbital: a study on molecular species of phosphatidyl choline. 
  • Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride. 
  • Evaluation of synthetic phospholipid ultrasound contrast agents. 
  • Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. 
  • Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. 
  • Extrinsic pathway proteolytic activity. 
  • Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease. 
  • Fat digestion in patients with bile acid malabsorption but minimal steatorrhea. 
  • Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. 
  • Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion. 
  • Hydration and steric pressures between phospholipid bilayers. 
  • Hydration force and bilayer deformation: a reevaluation. 
  • Hydration properties of lamellar and non-lamellar phases of phosphatidylcholine and phosphatidylethanolamine. 
  • Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. 
  • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). 
  • Impaired plasmalogens in patients with schizophrenia. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • In vivo acylation of triglycerides and phosphoglycerides of liver subcellular fractions with palmitate-1-14C in rats fed vitamin A. 
  • Incorporation of palmitate-1-14C into liver lipids of rats fed millet (Sorghum vulgarie) at different protein levels. 
  • Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia. 
  • Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid. 
  • Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins. 
  • Induction of phosphatidylcholine biosynthesis via CDPcholine pathway in lung and liver of rats following intratracheal administration of DDT and endosulfan. 
  • Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells. 
  • Influence of lipid composition on physical properties and peg-mediated fusion of curved and uncurved model membrane vesicles: "nature's own" fusogenic lipid bilayer. 
  • Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats. 
  • Interaction of K7Fe3+P2W17O62H2 with supported bilayer lipid membranes on platinum electrode. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Interaction of halothane with lipid bilayers. 
  • Interaction of the antifolate antibiotic trimethoprim with phosphatidylcholine membranes: a 13C and 31P nuclear magnetic resonance study. 
  • Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers. 
  • Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. 
  • Isolated perfused lung--substrate utilization. 
  • Lateral diffusion in planar lipid bilayers. 
  • Ligatin: a peripheral membrane protein with covalently bound palmitic acid. 
  • Lipid bilayer and water proton magnetization transfer: effect of cholesterol. 
  • Lipid specificity of beta-hydroxybutyrate dehydrogenase activation. 
  • Lipidomics identifies a requirement for peroxisomal function during influenza virus replication. 
  • Locally synthesized phosphatidylcholine, but not protein, undergoes rapid retrograde axonal transport in the rat sciatic nerve. 
  • Long- and short-range interactions between phospholipid/ganglioside GM1 bilayers. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. 
  • Magnitude of the solvation pressure depends on dipole potential. 
  • Measurement of interbilayer adhesion energies. 
  • Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations. 
  • Membrane-protein structural mapping of chloroplast coupling factor in asolectin vesicles. 
  • Metabolic network failures in Alzheimer's disease: A biochemical road map. 
  • Metabolism of subfractions of phosphatidyl choline & phosphatidyl ethanolamine of liver & plasma of rats given retinol & phenobarbital. 
  • Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein. 
  • Modulation of poly(ethylene glycol)-induced fusion by membrane hydration: importance of interbilayer separation. 
  • Modulation of the binding of signal peptides to lipid bilayers by dipoles near the hydrocarbon-water interface. 
  • Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface. 
  • Molecular and cellular processing of lung surfactant. 
  • Molecular species of phosphatidyl choline and phosphatidyl ethanolamine in heart of rats given excess vitamin A. 
  • Morphology of the intermediate stages in the lamellar to hexagonal lipid phase transition. 
  • Mortality rates in comparative trials of formulations of amphotericin B. 
  • New structural model for mixed-chain phosphatidylcholine bilayers. 
  • Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation. 
  • O-Alkyl dioleoylphosphatidylcholinium compounds: the effect of varying alkyl chain length on their physical properties and in vitro DNA transfection activity. 
  • On the localization of ubiquinone in phosphatidylcholine bilayers. 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia. 
  • Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript. 
  • Pathogenesis of hepatic steatosis in the parenterally fed rat. 
  • Perinatal dietary supplementation with a commercial soy lecithin preparation: effects on behavior and brain biochemistry in the developing rat. 
  • Perinatal dietary supplementation with a soy lecithin preparation: effects on development of central catecholaminergic neurotransmitter systems. 
  • Phase-lifetime spectrophotometry of deoxycholate-purified bacteriorhodopsin reconstituted into asolectin vesicles. 
  • Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging. 
  • Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals. 
  • Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. 
  • Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. 
  • Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. 
  • Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. 
  • Physical and biological properties of cationic triesters of phosphatidylcholine. 
  • Plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine. Evidence for extensive phospholipase A1 hydrolysis and hepatic metabolism of the products. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. 
  • Polyphenols increase adhesion between lipid bilayers by forming interbilayer bridges. 
  • Porcine hepatic phospholipid efflux during reperfusion after cold ischemia. 
  • Potential role of aerosolized amphotericin B formulations in the prevention and adjunctive treatment of invasive fungal infections. 
  • Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine. 
  • Probing the ethanol-induced chain interdigitations in gel-state bilayers of mixed-chain phosphatidylcholines. 
  • Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. 
  • Proton magnetic resonance studies of the aggregation of taurine-conjugated bile salts. 
  • Purification and characterization of a lecithin-D(-)- -hydroxybutyrate dehydrogenase complex. 
  • Radioprotection of liver lipids of whole-body gamma-irradiated female rats by cystamine. 
  • Radioprotection of whole-body gamma irradiation induced alterations in lipid metabolism of liver and plasma by AET (S-2, aminoethyl isothiuronium Br. H. Br.) and serotonin in rats. 
  • Range of the solvation pressure between lipid membranes: dependence on the packing density of solvent molecules. 
  • Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. 
  • Retinol feeding and low and high density lipoproteins of plasma of rats. 
  • Ribosome-independent regulation of translocon composition and Sec61alpha conformation. 
  • Role of water in short-range repulsive and attractive interactions between macromolecules and bilayers. 
  • SERUM LIPIDS IN LEPROSY BY SILICIC ACID COLUMN CHROMATOGRAPHY. 
  • Safety of aerosolized amphotericin B lipid complex in lung transplant recipients. 
  • Separation & estimation of human serum lipids by silicic acid column chromatography. 
  • Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation. 
  • Solubility of carbon dioxide in lipid bilayer membranes and organic solvents. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Steady-state ATP synthesis by bacteriorhodopsin and chloroplast coupling factor co-reconstituted into asolectin vesicles. 
  • Steric repulsion between phosphatidylcholine bilayers. 
  • Structure and interactive properties of highly fluorinated phospholipid bilayers. 
  • Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol). 
  • Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides. 
  • Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. 
  • Studies of the ethanol-induced interdigitated gel phase in phosphatidylcholines using the fluorophore 1,6-diphenyl-1,3,5-hexatriene. 
  • Study of renal safety in amphotericin B lipid complex-treated patients. 
  • Successful use of amphotericin B lipid complex in the treatment of cryptococcosis. 
  • Surface ripples cause the large fluid spaces between gel phase bilayers containing small amounts of cholesterol. 
  • Temperature dependence of the repulsive pressure between phosphatidylcholine bilayers. 
  • The dielectric constant of phospholipid bilayers and the permeability of membranes to ions. 
  • The effect of cholesterol on the structure of phosphatidylcholine bilayers. 
  • The effect of ethanol on the phase transition temperature and the phase structure of monounsaturated phosphatidylcholines. 
  • The effect of phloretin on the hydration of egg phosphatidylcholine multilayers. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. 
  • The organization of n-alkanes in lipid bilayers. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Theoretical analysis of lipid transport in sciatic nerve. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transmission of a procoagulant signal from tissue factor-bearing cell to platelets. 
  • Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex. 
  • Ultrasonic attenuation measurements in phospholipid dispersions. 
  • Upake of plasma lipids by extrahepatic tissues of vitamin A fed rats. 
  • Use of liposomes as carriers for radiation synovectomy. 
  • Use of newer antifungal therapies in clinical practice: what do the data tell us? 
  • VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • Water permeability and mechanical strength of polyunsaturated lipid bilayers. 
  • Whole and disaturated lung phosphatidylcholine in cortisol-treated, intrauterine growth-retarded and twin control lambs at different gestational ages. 
  • X-ray diffraction to determine the thickness of raft and nonraft bilayers. 
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  Keywords of People

  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma