Phosphodiesterase Inhibitors
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Subject Areas on Research
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A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use.
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Adenylyl cyclase expression and modulation of cAMP in rat taste cells.
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Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells.
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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
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Chronic obstructive pulmonary disease: emerging medical therapies.
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Chronic thromboembolic pulmonary hypertension: detection, medical and surgical treatment approach, and current outcomes.
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Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
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Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
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E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.
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Erectile function after posterior urethroplasty for pelvic fracture-urethral distraction defect injuries.
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Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.
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Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.
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Host-Directed Therapies for Tuberculosis.
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Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
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Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms.
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Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.
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Intravenous milrinone in cardiac surgery.
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Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase.
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Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
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Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras.
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Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.
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New cardiac drugs.
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New concepts in the treatment of anaphylactoid reactions in anesthesia.
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Newer pharmacologic alternatives for erectile dysfunction.
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PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support.
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Pharmacodynamics and pharmacokinetics of milrinone administration to increase oxygen delivery in critically ill patients.
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Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery.
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Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome.
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Phosphodiesterase inhibitors: the inotropes of choice for the new millennium?
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Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.
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Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.
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Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis.
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Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery.
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Prevention of chronic cerebral vasospasm in dogs with milrinone.
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Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
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Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma.
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Randomized controlled trial investigating the effect of transcervical papaverine and bupivacaine on postoperative analgesia following laparoscopic sterilization.
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Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis.
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Rationale and design of the OPTIME CHF trial: outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure.
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Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.
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Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
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Regulation of insulin secretion from novel engineered insulinoma cell lines.
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Retinal effects of 6 months of daily use of tadalafil or sildenafil.
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Sexual dysfunction in men and women with endocrine disorders.
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Sildenafil improves walk distance in idiopathic pulmonary fibrosis.
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Support of the perioperative failing heart with preexisting ventricular dysfunction: currently available options.
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The effects of milrinone on platelets in patients undergoing cardiac surgery.
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The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery.
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Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver.
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Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes.
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beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
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Keywords of People