Phospholipid Ethers

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  Subject Areas on Research

  • A phase 1 study of 131I-CLR1404 in patients with relapsed or refractory advanced solid tumors: dosimetry, biodistribution, pharmacokinetics, and safety. 
  • Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. 
  • The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.