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Subject Areas on Research
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A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.
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A dose dependent relationship between vitamin A and brain myelin lipids in vitamin A deficient rats.
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A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria.
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A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma.
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A new helper phospholipid for gene delivery.
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A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii.
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A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.
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A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products.
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A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.
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ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat.
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Abnormal lipid composition of the red cell membrane in congenital dyserythropoietic anemia type II (HEMPAS).
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Activation of factor X by factor VIIa on monocyte cell surfaces.
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Altered surfactant function and structure in SP-A gene targeted mice.
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Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study.
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An electron spin resonance study of cholestane spin label in aqueous mixtures of biliary lipids.
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An inner activation gate controls TMEM16F phospholipid scrambling.
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An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A.
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Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipids.
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Antiphospholipid antibodies and recurrent pregnancy loss.
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Application of the temperature-jump technique to the study of phospholipid dispersions.
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Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry.
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Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes.
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BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models.
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Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation.
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Bile compositional changes and cholesterol stone formation following orthotopic liver transplantation.
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Biliary response to glucagon and insulin following hepatic transplantation in humans.
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Biliary response to glucagon in humans.
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Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion.
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Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding.
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Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery.
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Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression.
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Cardiolipin and the osmotic stress responses of bacteria.
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Cell-directed assembly of lipid-silica nanostructures providing extended cell viability.
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Changes in lipid values and lipoprotein patterns of serum samples contaminated with bacteria.
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Changes in the lung after prolonged positive pressure ventilation in normal baboons.
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Chemoattractant-induced membrane phenomena of phagocytes.
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Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.
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Cholinergic stimulation of phosphatidylinositol hydrolysis by rat corneal epithelium in vitro.
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Coagulation factor interaction with platelets.
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Coaxial continuous flow fast atom bombardment in conjunction with tandem mass spectrometry for the analysis of biomolecules.
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Comparative effectiveness of surfactant preparations in premature infants.
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Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.
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Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding.
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Cooperativity and binding in the mechanism of cytosolic phospholipase A2.
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Cytosolic phospholipase A2 shows burst kinetics consistent with the slow, reversible formation of a dead-end complex.
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Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content.
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Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids.
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Deletion analysis of recombinant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domain.
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Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome.
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Detection of hepatic metastases from colorectal cancer: prospective evaluation of gray scale US versus SonoVue® low mechanical index real time-enhanced US as compared with multidetector-CT or Gd-BOPTA-MRI.
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Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain.
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Dexamethasone increases adult rat lung surfactant lipids.
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Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.
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Disseminated intravascular coagulation (DIC): an approach.
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Early extracellular and cellular lipid deposits in aorta of cholesterol-fed rabbits.
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Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids.
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Effect of dihydrostreptomycin on tissue lipid of guinea-pigs.
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Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats.
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Effect of glucagon and insulin upon biliary lipid secretion.
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Effect of hypervitaminosis A on intestinal lipids of rats.
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Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells.
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Effect of retinol and retinoic acid on liver lipids of rats fed different levels of protein.
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Effect of vertical sleeve gastrectomy on food selection and satiation in rats.
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Effect of whole body gamma irradiation on rat plasma phospholipids & the effect of S-beta-aminoethylisothiouronium bromide hydrobromide.
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Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.
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Effects of bombesin on fasting bile formation.
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Effects of elaidic acid on lipid metabolism in HepG2 cells, investigated by an integrated approach of lipidomics, transcriptomics and proteomics.
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Effects of feeding ethyl-dihomo-gamma-linolenate on rabbit renomedullary lipid composition and prostaglandin production in vitro.
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Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters.
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Effects of phytanic acid on the vitamin E status, lipid composition and physical properties of retinal cell membranes: implications for adult Refsum disease.
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Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats.
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Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids.
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Electrostatic control of phospholipid polymorphism.
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Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation.
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Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.
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Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid.
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Experimental tests for protrusion and undulation pressures in phospholipid bilayers.
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FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.
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Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding.
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Formation and dynamics of supported phospholipid membranes on a periodic nanotextured substrate.
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Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
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Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation.
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Gb(3)/creatinine biomarkers for Fabry disease: issues to consider.
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Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.
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Glucagon or insulin suppressed biliary lipid excretion in dog and man.
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Glycerol as an indicator of lipid degradation in bicuculline-induced seizures and experimental cerebral ischemia.
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Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.
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Hepatic mitochondrial membrane lipid environment and protein nutrition.
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Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism.
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Hydration and steric pressures between phospholipid bilayers.
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Hydration properties of lamellar and non-lamellar phases of phosphatidylcholine and phosphatidylethanolamine.
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Hydrocortisone inhibits mucin secretion from guinea pig gallbladder.
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Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.
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IL-1 receptors: structure and signals.
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Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus.
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Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver.
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Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
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Impaired Myelination in rats given excess vitamin A postnatally.
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Increased Ca2+ -ATPase activity associated with methylation of phospholipids in human erythrocytes.
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Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.
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Increases in serum sphingomyelin by 17 beta-estradiol.
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Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars.
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Inhibition of bile flow by intravenous arginine hydrochloride.
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Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats.
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Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism.
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Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments.
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Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease.
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Isolation of lysophosphatidylethanolamine from human serum.
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Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2.
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Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis.
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Lipid specificity of beta-hydroxybutyrate dehydrogenase activation.
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Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis.
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Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization.
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Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
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Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
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Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.
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Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors.
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Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.
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Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores.
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Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation.
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Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase.
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Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product.
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Membrane-protein structural mapping of chloroplast coupling factor in asolectin vesicles.
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Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.
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Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants.
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Mixed connective tissue disease with arterial thrombosis, antiphospholipid antibodies and heparin induced thrombocytopenia.
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Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
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Molecular species of phosphatidyl choline and phosphatidyl ethanolamine in heart of rats given excess vitamin A.
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Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.
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Multilamellar bodies in alveolar septal cells.
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Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.
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Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
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Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging.
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Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit.
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Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2.
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Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens.
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Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.
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Nuclear magnetic resonance spectroscopy: new insights into the pathophysiology of mood disorders.
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Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-1 receptors, and H-1 receptor-mediated stimulation of phospholipid turnover.
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Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data.
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PHOSPHOLIPIDS OF THE SEXUAL SEGMENT OF THE KIDNEY OF THE INDIAN HOUSE LIZARD, HEMIDACTYLUS FLAVIVIRIDIS RUPPELL.
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Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation.
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Phase-lifetime spectrophotometry of deoxycholate-purified bacteriorhodopsin reconstituted into asolectin vesicles.
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Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
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Phosphoinositides of sheep platelets plasma membranes.
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Phospholipid hydrolytic enzymes in a 'cesspool' of arterial intimal lipoproteins: a mechanism for atherogenic lipid accumulation.
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Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.
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Phospholipid membrane stabilization by dimethylsulfoxide and other inducers of Friend leukemic cell differentiation.
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Phospholipid methylation in macrophages is inhibited by chemotactic factors.
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Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.
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Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII.
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Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines.
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Phospholipids in the androgen stimulated sexual segment of the kidney of the Indian house lizard, Hemidactylus flaviviridis Rüppell.
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Plasma lipoproteins of free-ranging howling monkeys (Alouatta palliata).
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Platelet binding and activity of recombinant factor VIIa.
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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.
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Predicting neonatal respiratory morbidity by lamellar body count and gestational age.
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Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine.
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Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2.
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Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes.
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Prothrombin and beta 2-glycoprotein I frequently contribute to antiphospholipid antibody interactions with phospholipids and the generation of abnormal waveform profiles in coagulation assays.
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Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats.
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Pulmonary surfactant lipid production in oxygen-exposed rat lungs.
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Pulmonary toxicity of trichloroethylene: induction of changes in surfactant phospholipids and phospholipase A2 activity in the mouse lung.
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Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
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RAT PLASMA PHOSPHOLIPIDS IN HYPERVITAMINOSIS A.
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Radical decay kinetics in ferrocytochrome c model membranes. A spin label study.
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Radioprotection of liver lipids of whole-body gamma-irradiated female rats by cystamine.
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Radioprotection of whole-body gamma irradiation induced alterations in lipid metabolism of liver and plasma by AET (S-2, aminoethyl isothiuronium Br. H. Br.) and serotonin in rats.
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Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol).
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Reassembled plasma low density lipoproteins. Phospholipid-cholesterol ester-apoprotein B complexes.
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Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.
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Reconstitution of the beta-adrenergic receptor.
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Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure.
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Regulation of beta-adrenergic receptors by phospholipid methylation.
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Regulation of biliary protein secretion in dogs.
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Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes.
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Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase.
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Regulation of the actin cytoskeleton by inositol phospholipid pathways.
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Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids.
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Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury.
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Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments.
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Retinol & membrane functions: phospholipid exchange between liver microsomes & mitochondria in rats fed retinol.
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Retinol and adrenal lipids of rats.
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Rhoptry secretion of membranous whorls by Plasmodium falciparum merozoites.
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Role of transmethylation reactions in cellular motility and phagocytosis.
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Roles of bilayer material properties in function and distribution of membrane proteins.
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Rotational dynamics of chloroplast ATP synthase in phospholipid vesicles.
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SERUM LIPIDS IN LEPROSY BY SILICIC ACID COLUMN CHROMATOGRAPHY.
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Seasonal variations in the pattern of lipids in the sexual segment, kidney and liver of the Indian house lizard, Hemidactylus flaviviridis Ruppell.
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Sensitivity of coded aperture Raman spectroscopy to analytes beneath turbid biological tissue and tissue-simulating phantoms.
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Separation of retinol from neutral lipids and phospholipids by silicic acid.
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Separation of six lipid classes on one thin-layer chromatogram.
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Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
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Spleen lipids: effect of whole body gamma irradiation and radioprotective chemicals.
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Stable and fluid multilayer phospholipid-silica thin films: mimicking active multi-lamellar biological assemblies.
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Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant.
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Steady-state ATP synthesis by bacteriorhodopsin and chloroplast coupling factor co-reconstituted into asolectin vesicles.
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Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria.
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Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida.
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Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides.
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Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance.
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Studies on mode of action of vitamin A.
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Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver- a morphological and biochemical study.
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Superficial migratory thrombophlebitis and the lupus anticoagulant.
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Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone.
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Synthesis and characterization of carbohydrate-based phospholipids.
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The Haemophilus influenzae Type b hcsA and hcsB gene products facilitate transport of capsular polysaccharide across the outer membrane and are essential for virulence.
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The cellular lipids of Romboutsia.
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The effect of phosphatidylserine on the inhibition of human factor Xa by the plasma proteinase inhibitors.
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The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients.
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The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles.
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The effects of liver denervation on the regulation of hepatic biliary secretion.
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The electrical conductivity of phospholipid films as an iodine-sensing mechanism.
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The evaluation of complex-dependent alterations in human factor VIIa.
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The influence of follicle-stimulating hormone on testicular phospholipids.
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The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays.
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The lipids of the erythrocyte in paroxysmal nocturnal hemoglobinuria.
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The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics.
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The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack.
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The size and curvature of anionic covesicle substrate affects the catalytic action of cytosolic phospholipase A2.
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The stimulation of cellular phospholipid uptake by surfactant apoproteins.
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Time-resolved CT angiography for the detection and classification of endoleaks.
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Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
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Transductional mechanisms of chemoattractant receptors on leukocytes.
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Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.
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Transport properties of the calcium ionophore ETH-129.
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Turnover of pancreas phospholipids in rats fed inadequate dietary protein.
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Ultrasonic attenuation measurements in phospholipid dispersions.
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Upake of plasma lipids by extrahepatic tissues of vitamin A fed rats.
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Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis.
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Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure.
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Yolk lipids of developing atherosclerosis susceptible White Carneau and atherosclerosis resistant Show Racer pigeon embryos.
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beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.
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Keywords of People
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Bennett, Vann,
George B. Geller Professor for Research in Molecular Biology in the School of Medicine,
Duke Cancer Institute
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Guan, Ziqiang,
Research Professor in Biochemistry,
Biochemistry
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Muir, Kelly Walton,
Associate Professor of Ophthalmology,
Ophthalmology, Glaucoma
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Wax, Adam P.,
Professor of Biomedical Engineering,
Biomedical Engineering