Phospholipids

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  Subject Areas on Research

  • A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface. 
  • A dose dependent relationship between vitamin A and brain myelin lipids in vitamin A deficient rats. 
  • A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria. 
  • A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma. 
  • A new helper phospholipid for gene delivery. 
  • A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii. 
  • A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 
  • A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae. 
  • Abnormal lipid composition of the red cell membrane in congenital dyserythropoietic anemia type II (HEMPAS). 
  • Activation of factor X by factor VIIa on monocyte cell surfaces. 
  • Altered surfactant function and structure in SP-A gene targeted mice. 
  • Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study. 
  • An electron spin resonance study of cholestane spin label in aqueous mixtures of biliary lipids. 
  • An inner activation gate controls TMEM16F phospholipid scrambling. 
  • An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A. 
  • Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipids. 
  • Antiphospholipid antibodies and recurrent pregnancy loss. 
  • Application of the temperature-jump technique to the study of phospholipid dispersions. 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. 
  • Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation. 
  • Bile compositional changes and cholesterol stone formation following orthotopic liver transplantation. 
  • Biliary response to glucagon and insulin following hepatic transplantation in humans. 
  • Biliary response to glucagon in humans. 
  • Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion. 
  • Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding. 
  • Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression. 
  • Cardiolipin and the osmotic stress responses of bacteria. 
  • Changes in lipid values and lipoprotein patterns of serum samples contaminated with bacteria. 
  • Changes in the lung after prolonged positive pressure ventilation in normal baboons. 
  • Chemoattractant-induced membrane phenomena of phagocytes. 
  • Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. 
  • Cholinergic stimulation of phosphatidylinositol hydrolysis by rat corneal epithelium in vitro. 
  • Coagulation factor interaction with platelets. 
  • Coaxial continuous flow fast atom bombardment in conjunction with tandem mass spectrometry for the analysis of biomolecules. 
  • Comparative effectiveness of surfactant preparations in premature infants. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. 
  • Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. 
  • Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. 
  • Deletion analysis of recombinant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domain. 
  • Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. 
  • Detection of hepatic metastases from colorectal cancer: prospective evaluation of gray scale US versus SonoVue® low mechanical index real time-enhanced US as compared with multidetector-CT or Gd-BOPTA-MRI. 
  • Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors. 
  • Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain. 
  • Dexamethasone increases adult rat lung surfactant lipids. 
  • Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. 
  • Disseminated intravascular coagulation (DIC): an approach. 
  • Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. 
  • Early extracellular and cellular lipid deposits in aorta of cholesterol-fed rabbits. 
  • Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids. 
  • Effect of dihydrostreptomycin on tissue lipid of guinea-pigs. 
  • Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats. 
  • Effect of glucagon and insulin upon biliary lipid secretion. 
  • Effect of hypervitaminosis A on intestinal lipids of rats. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Effect of retinol and retinoic acid on liver lipids of rats fed different levels of protein. 
  • Effect of vertical sleeve gastrectomy on food selection and satiation in rats. 
  • Effect of whole body gamma irradiation on rat plasma phospholipids & the effect of S-beta-aminoethylisothiouronium bromide hydrobromide. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of bombesin on fasting bile formation. 
  • Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters. 
  • Effects of phytanic acid on the vitamin E status, lipid composition and physical properties of retinal cell membranes: implications for adult Refsum disease. 
  • Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats. 
  • Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids. 
  • Electrostatic control of phospholipid polymorphism. 
  • Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. 
  • Experimental tests for protrusion and undulation pressures in phospholipid bilayers. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation. 
  • Gb(3)/creatinine biomarkers for Fabry disease: issues to consider. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Glucagon or insulin suppressed biliary lipid excretion in dog and man. 
  • Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. 
  • Hepatic mitochondrial membrane lipid environment and protein nutrition. 
  • Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism. 
  • Hydration and steric pressures between phospholipid bilayers. 
  • Hydration properties of lamellar and non-lamellar phases of phosphatidylcholine and phosphatidylethanolamine. 
  • Hydrocortisone inhibits mucin secretion from guinea pig gallbladder. 
  • IL-1 receptors: structure and signals. 
  • Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus. 
  • Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver. 
  • Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. 
  • Impaired Myelination in rats given excess vitamin A postnatally. 
  • Increased Ca2+ -ATPase activity associated with methylation of phospholipids in human erythrocytes. 
  • Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. 
  • Increases in serum sphingomyelin by 17 beta-estradiol. 
  • Inhibition of bile flow by intravenous arginine hydrochloride. 
  • Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments. 
  • Isolation of lysophosphatidylethanolamine from human serum. 
  • Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis. 
  • Lipid specificity of beta-hydroxybutyrate dehydrogenase activation. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization. 
  • Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. 
  • Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. 
  • Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity. 
  • Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors. 
  • Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo. 
  • Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores. 
  • Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation. 
  • Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. 
  • Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. 
  • Membrane-protein structural mapping of chloroplast coupling factor in asolectin vesicles. 
  • Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Mixed connective tissue disease with arterial thrombosis, antiphospholipid antibodies and heparin induced thrombocytopenia. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Molecular species of phosphatidyl choline and phosphatidyl ethanolamine in heart of rats given excess vitamin A. 
  • Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. 
  • Multilamellar bodies in alveolar septal cells. 
  • Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. 
  • Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit. 
  • Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Nuclear magnetic resonance spectroscopy: new insights into the pathophysiology of mood disorders. 
  • Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-1 receptors, and H-1 receptor-mediated stimulation of phospholipid turnover. 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • PHOSPHOLIPIDS OF THE SEXUAL SEGMENT OF THE KIDNEY OF THE INDIAN HOUSE LIZARD, HEMIDACTYLUS FLAVIVIRIDIS RUPPELL. 
  • Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation. 
  • Phase-lifetime spectrophotometry of deoxycholate-purified bacteriorhodopsin reconstituted into asolectin vesicles. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging. 
  • Phosphoinositides of sheep platelets plasma membranes. 
  • Phospholipid hydrolytic enzymes in a 'cesspool' of arterial intimal lipoproteins: a mechanism for atherogenic lipid accumulation. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phospholipid membrane stabilization by dimethylsulfoxide and other inducers of Friend leukemic cell differentiation. 
  • Phospholipid methylation in macrophages is inhibited by chemotactic factors. 
  • Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. 
  • Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. 
  • Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. 
  • Phospholipids in the androgen stimulated sexual segment of the kidney of the Indian house lizard, Hemidactylus flaviviridis Rüppell. 
  • Plasma lipoproteins of free-ranging howling monkeys (Alouatta palliata). 
  • Platelet binding and activity of recombinant factor VIIa. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Predicting neonatal respiratory morbidity by lamellar body count and gestational age. 
  • Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine. 
  • Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes. 
  • Prothrombin and beta 2-glycoprotein I frequently contribute to antiphospholipid antibody interactions with phospholipids and the generation of abnormal waveform profiles in coagulation assays. 
  • Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats. 
  • Pulmonary surfactant lipid production in oxygen-exposed rat lungs. 
  • Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. 
  • RAT PLASMA PHOSPHOLIPIDS IN HYPERVITAMINOSIS A. 
  • Radical decay kinetics in ferrocytochrome c model membranes. A spin label study. 
  • Radioprotection of liver lipids of whole-body gamma-irradiated female rats by cystamine. 
  • Radioprotection of whole-body gamma irradiation induced alterations in lipid metabolism of liver and plasma by AET (S-2, aminoethyl isothiuronium Br. H. Br.) and serotonin in rats. 
  • Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). 
  • Reassembled plasma low density lipoproteins. Phospholipid-cholesterol ester-apoprotein B complexes. 
  • Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. 
  • Reconstitution of the beta-adrenergic receptor. 
  • Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of biliary protein secretion in dogs. 
  • Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. 
  • Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase. 
  • Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids. 
  • Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. 
  • Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments. 
  • Retinol & membrane functions: phospholipid exchange between liver microsomes & mitochondria in rats fed retinol. 
  • Retinol and adrenal lipids of rats. 
  • Role of transmethylation reactions in cellular motility and phagocytosis. 
  • Roles of bilayer material properties in function and distribution of membrane proteins. 
  • Rotational dynamics of chloroplast ATP synthase in phospholipid vesicles. 
  • SERUM LIPIDS IN LEPROSY BY SILICIC ACID COLUMN CHROMATOGRAPHY. 
  • Seasonal variations in the pattern of lipids in the sexual segment, kidney and liver of the Indian house lizard, Hemidactylus flaviviridis Ruppell. 
  • Sensitivity of coded aperture Raman spectroscopy to analytes beneath turbid biological tissue and tissue-simulating phantoms. 
  • Separation of retinol from neutral lipids and phospholipids by silicic acid. 
  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. 
  • Spleen lipids: effect of whole body gamma irradiation and radioprotective chemicals. 
  • Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. 
  • Steady-state ATP synthesis by bacteriorhodopsin and chloroplast coupling factor co-reconstituted into asolectin vesicles. 
  • Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida. 
  • Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides. 
  • Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance. 
  • Studies on mode of action of vitamin A. 
  • Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver- a morphological and biochemical study. 
  • Superficial migratory thrombophlebitis and the lupus anticoagulant. 
  • Surfactant Administration in Preterm Infants: Drug Development Opportunities. 
  • Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone. 
  • Synthesis and characterization of carbohydrate-based phospholipids. 
  • The cellular lipids of Romboutsia. 
  • The effect of phosphatidylserine on the inhibition of human factor Xa by the plasma proteinase inhibitors. 
  • The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. 
  • The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles. 
  • The effects of liver denervation on the regulation of hepatic biliary secretion. 
  • The electrical conductivity of phospholipid films as an iodine-sensing mechanism. 
  • The evaluation of complex-dependent alterations in human factor VIIa. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays. 
  • The lipids of the erythrocyte in paroxysmal nocturnal hemoglobinuria. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. 
  • The stimulation of cellular phospholipid uptake by surfactant apoproteins. 
  • Time-resolved CT angiography for the detection and classification of endoleaks. 
  • Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. 
  • Transductional mechanisms of chemoattractant receptors on leukocytes. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Turnover of pancreas phospholipids in rats fed inadequate dietary protein. 
  • Ultrasonic attenuation measurements in phospholipid dispersions. 
  • Upake of plasma lipids by extrahepatic tissues of vitamin A fed rats. 
  • Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering