Phosphoric Monoester Hydrolases
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Subject Areas on Research
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A human protein with antimutator activity.
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A prospective view on phosphatases and replicative senescence.
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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
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APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2.
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Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.
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Activities of the hepatic enzymes of vitamin B6 metabolism for patients with cirrhosis.
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Additional evidence that PGAP1 loss of function causes autosomal recessive global developmental delay and encephalopathy.
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Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.
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Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.
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Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase.
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Biosensor system for continuous monitoring of organophosphate aerosols.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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Caspases and kinases in a death grip.
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Cell surface polarization during yeast mating.
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Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.
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Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.
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Control of meristem determinacy by trehalose 6-phosphate phosphatases is uncoupled from enzymatic activity.
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Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
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Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells.
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Cytokinesis.
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Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.
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Detection of phosphorylation by enzymatic techniques.
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Detection of phosphorylation by enzymatic techniques.
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Diverse proteins homologous to inositol monophosphatase.
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Endosome and INPP4B.
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Feedback control of T-cell receptor activation.
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Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
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GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability.
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Gene expression profiling and genetic markers in glioblastoma survival.
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Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans.
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Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
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Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
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Guanosinetriphosphatase activity of tubulin associated with microtubule assembly.
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Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism.
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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
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INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype.
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Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae.
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Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
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In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
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Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
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Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.
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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
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Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase.
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Large-scale profiling of Rab GTPase trafficking networks: the membrome.
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Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.
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Mechanisms of action of rapamycin in gliomas.
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Metabolism of vitamin B-6 by human liver.
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Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein.
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Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
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Modulation of inositol phospholipid metabolism by polyamines.
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Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.
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Molecular pathogenesis of malignant gliomas.
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Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
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Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
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Mutational analysis of the PTEN gene in human uterine sarcomas.
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Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
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Myelin basic protein phosphatase activity in rat brain.
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Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.
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Nuclear inositol signaling: a structural and functional approach.
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On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision.
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Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.
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Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis.
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Overview of protein phosphorylation.
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PI3K/Akt and apoptosis: size matters.
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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.
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PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.
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PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects.
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PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.
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PTEN polymorphism (IVS4) is not associated with risk of prostate cancer.
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Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
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Phosphatases join kinases in DNA-damage response pathways.
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Phosphatidic acid phosphatase in neonatal rat lung: effects of prenatal dexamethasone or terbutaline treatment on basal activity and on responsiveness to beta adrenergic stimulation.
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Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.
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Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
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Phosphoinositide phosphatases and disease.
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Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage.
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Polyethylene glycol-stimulated microsomal GTP hydrolysis. Relationship to GTP-mediated Ca2+ release.
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Post-translational modifications regulate the ticking of the circadian clock.
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Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver.
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Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers.
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Regular structures in unit membranes. II. Morphological and biochemical characterization of two water-soluble membrane proteins isolated from the suckling rat ileum.
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Roles for nucleotide phosphatases in sulfate assimilation and skeletal disease.
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SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases.
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SMAD4 is required for development of maximal endotoxin tolerance.
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Selective linkage of beta-adrenergic receptors to functional responses in developing rat lung and liver: phosphatidic acid phosphatase, ornithine decarboxylase and lung liquid reabsorption.
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Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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SnapShot: Inositol phosphates.
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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
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Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
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The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis.
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The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
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The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.
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The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
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Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli.
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Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.
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Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
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Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
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Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.
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When the checkpoints have gone: insights into Cdc25 functional activation.
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YbiV from Escherichia coli K12 is a HAD phosphatase.
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miR-181a is an intrinsic modulator of T cell sensitivity and selection.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Guan, Ziqiang,
Research Professor in Biochemistry,
Biochemistry
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology