Phosphoric Monoester Hydrolases

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  Subject Areas on Research

  • A prospective view on phosphatases and replicative senescence. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2. 
  • Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer. 
  • Activities of the hepatic enzymes of vitamin B6 metabolism for patients with cirrhosis. 
  • Additional evidence that PGAP1 loss of function causes autosomal recessive global developmental delay and encephalopathy. 
  • Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. 
  • Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels. 
  • Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. 
  • Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. 
  • Biosensor system for continuous monitoring of organophosphate aerosols. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • Cell surface polarization during yeast mating. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Detection of phosphorylation by enzymatic techniques. 
  • Detection of phosphorylation by enzymatic techniques. 
  • Feedback control of T-cell receptor activation. 
  • Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. 
  • GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Guanosinetriphosphatase activity of tubulin associated with microtubule assembly. 
  • Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism. 
  • Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. 
  • INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype. 
  • Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. 
  • Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Large-scale profiling of Rab GTPase trafficking networks: the membrome. 
  • Lhermitte-Duclos disease and Cowden disease: clinical and genetic study in five patients with Lhermitte-Duclos disease and literature review. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Mechanisms of action of rapamycin in gliomas. 
  • Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. 
  • Metabolism of vitamin B-6 by human liver. 
  • Modulation of inositol phospholipid metabolism by polyamines. 
  • Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. 
  • Molecular pathogenesis of malignant gliomas. 
  • Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. 
  • Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers. 
  • Mutational analysis of the PTEN gene in human uterine sarcomas. 
  • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. 
  • Non-endemic Burkitts's lymphoma. A B-cell tumor related to germinal centers. 
  • Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function. 
  • Nuclear inositol signaling: a structural and functional approach. 
  • On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision. 
  • Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. 
  • Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis. 
  • Overview of protein phosphorylation. 
  • PI3K/Akt and apoptosis: size matters. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. 
  • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. 
  • PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. 
  • Phenotypic spectrum and prevalence of INPP5E mutations in Joubert syndrome and related disorders. 
  • Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins. 
  • Phosphatases join kinases in DNA-damage response pathways. 
  • Phosphatidic acid phosphatase in neonatal rat lung: effects of prenatal dexamethasone or terbutaline treatment on basal activity and on responsiveness to beta adrenergic stimulation. 
  • Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Polyethylene glycol-stimulated microsomal GTP hydrolysis. Relationship to GTP-mediated Ca2+ release. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. 
  • Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers. 
  • Regular structures in unit membranes. II. Morphological and biochemical characterization of two water-soluble membrane proteins isolated from the suckling rat ileum. 
  • Roles for nucleotide phosphatases in sulfate assimilation and skeletal disease. 
  • SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. 
  • SMAD4 is required for development of maximal endotoxin tolerance. 
  • Selective linkage of beta-adrenergic receptors to functional responses in developing rat lung and liver: phosphatidic acid phosphatase, ornithine decarboxylase and lung liquid reabsorption. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • SnapShot: Inositol phosphates. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. 
  • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. 
  • Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments. 
  • Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus. 
  • Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. 
  • miR-181a is an intrinsic modulator of T cell sensitivity and selection. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology