Phosphoprotein Phosphatases
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Subject Areas on Research
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A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
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A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits.
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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
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A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
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A phosphatase controls the fate of receptor-regulated Smads.
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A prospective view on phosphatases and replicative senescence.
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A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.
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A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.
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A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha.
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
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ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
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Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants.
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Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.
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Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.
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Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.
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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
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Analysis of protein phosphatases: toolbox for unraveling cell signaling networks.
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Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase.
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Angiotensin II type 2 receptor mediates programmed cell death.
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Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
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Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
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Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.
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Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis.
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B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.
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Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
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Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.
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Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
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Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
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Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
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Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit.
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Characterization of neuronal protein phosphatases in Aplysia californica.
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Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B.
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Control of cell function by reversible protein phosphorylation.
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Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells.
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Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I.
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Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1.
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Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.
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Dephosphorylation of distinct sites on microtubule-associated protein MAP1B by protein phosphatases 1, 2A and 2B.
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Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.
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Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.
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Detection of phosphorylation by enzymatic techniques.
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Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.
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Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
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Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A.
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Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.
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Domain II of calmodulin is involved in activation of calcineurin.
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Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.
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Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
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Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei.
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Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
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Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation.
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Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
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Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.
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Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.
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Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions.
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From promiscuity to precision: protein phosphatases get a makeover.
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Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
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Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans.
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Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
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Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.
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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
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Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
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Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression.
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Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.
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Identification of a new family of protein phosphatase 2A regulatory subunits.
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Identification of cellular protein phosphatase-1 regulators.
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Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatography.
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Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm.
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Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
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Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method.
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Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones.
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Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
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Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
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Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators.
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Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.
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Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters.
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Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3.
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Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1.
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Inhibitor-1, a regulator of protein phosphatase 1 function.
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Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
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Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.
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Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
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Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
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Isolation of an active fragment of protein phosphatase inhibitor-I from rabbit skeletal muscle.
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Kinetic analysis of the catalytic domain of human cdc25B.
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Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.
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Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import.
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Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.
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Mechanisms of beta-adrenergic receptor desensitization and resensitization.
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Meeting report: targeting protein phosphatases-medicines for the new millenium.
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Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.
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Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
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Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M.
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Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation.
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Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.
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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
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Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.
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Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
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Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation.
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Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.
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Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density.
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Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote.
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Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.
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Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.
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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
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Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
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Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.
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Overview of protein phosphorylation.
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PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
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PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.
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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
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Phosphatases driving mitosis: pushing the gas and lifting the brakes.
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Phosphoproteome analysis in yeast.
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Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.
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Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase.
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Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.
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Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage.
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Physiologic importance of protein phosphatase inhibitors.
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Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate.
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Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
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Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex.
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Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.
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Protein (serine and threonine) phosphate phosphatases.
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Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.
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Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
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Protein phosphatase 1 regulates the stability of the circadian protein PER2.
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Protein phosphatase 1 regulation by inhibitors and targeting subunits.
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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.
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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
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Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.
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Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1.
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Protein phosphatase 2A: a panoply of enzymes.
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Protein phosphatase 5 is required for ATR-mediated checkpoint activation.
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Protein phosphatase regulation by endogenous inhibitors.
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Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica.
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Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
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Protein phosphatases: recent progress.
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Protein phosphorylation: hormones, drugs, and bioregulation.
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Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory.
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Protein serine/threonine phosphatases--new avenues for cell regulation.
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Protein serine/threonine phosphatases: life, death, and sleeping.
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Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions.
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Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.
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Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.
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Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.
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RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms.
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Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1.
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Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor.
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Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome.
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Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.
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Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
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Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.
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Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.
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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
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Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
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Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.
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Regulation of epithelial chloride channels by protein phosphatase.
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Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
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Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
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Regulation of synaptic strength by protein phosphatase 1.
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Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
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Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A.
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Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.
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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
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Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.
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Reversible protein phosphorylation regulates circadian rhythms.
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Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
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Role of calcium in T-lymphocyte activation.
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Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss.
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Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
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Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
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Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.
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Synthesis and use of the protein phosphatase affinity matrices microcystin-sepharose and microcystin-biotin-sepharose.
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TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors.
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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
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Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.
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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
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The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
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The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
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The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
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The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products.
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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
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The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
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The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.
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The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.
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The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function.
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The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
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The role of protein phosphatases in synaptic transmission, plasticity and neuronal development.
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The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia.
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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.
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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
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Translating protein phosphatase research into treatments for neurodegenerative diseases.
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Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
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Use of okadaic acid to inhibit protein phosphatases in intact cells.
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Use of protein phosphatase inhibitors.
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Use of protein phosphatase inhibitors.
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YbiV from Escherichia coli K12 is a HAD phosphatase.
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cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72.
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vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.