Phosphoproteins

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  Subject Areas on Research

  • A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. 
  • A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. 
  • A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. 
  • A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. 
  • A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A positive addition to a negative tail's tale. 
  • A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion. 
  • A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. 
  • Absence of synaptic regulation by phosducin in retinal slices. 
  • Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. 
  • Activation of transducin guanosine triphosphatase by two proteins of the RGS family. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. 
  • Adaptor proteins in lymphocyte activation. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 
  • Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Alteration of aminoacyl-tRNA synthetase activities by phosphorylation with casein kinase I. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. 
  • Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. 
  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 
  • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 
  • Anxiety-like behaviors in mice lacking GIT2. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. 
  • Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. 
  • Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. 
  • Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. 
  • Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. 
  • Association of the polyomavirus middle-T antigen with c-yes protein. 
  • Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells. 
  • Axokinin phosphorylation by cAMP-dependent protein kinase is sufficient for activation of sperm flagellar motility. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. 
  • Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. 
  • Binding of G protein beta gamma-subunits to pleckstrin homology domains. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation. 
  • CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. 
  • CRP: Cleavage of Radiolabeled Phosphoproteins. 
  • Ca2+ regulation of sperm axonemal motility. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Calcineurin Targets Involved in Stress Survival and Fungal Virulence. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. 
  • Cell adhesion: separation of p120's powers? 
  • Cell biology. Enforcing the Greatwall in mitosis. 
  • Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules. 
  • Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. 
  • Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. 
  • Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Cohesin: it's not just for chromosomes anymore. 
  • Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Control of cell function by reversible protein phosphorylation. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. 
  • Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study. 
  • Decreased intracellular potassium levels underlie increased progesterone synthesis during ovarian follicular atresia. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. 
  • Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival? 
  • Detection of phosphorylation by enzymatic techniques. 
  • Detection of phosphorylation by enzymatic techniques. 
  • Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling. 
  • Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza. 
  • Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. 
  • Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus. 
  • Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. 
  • Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer. 
  • Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. 
  • Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 
  • Dysregulated activation of fetal liver programme in acute liver failure. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. 
  • Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. 
  • Endosomal cAMP production broadly impacts the cellular phosphoproteome. 
  • Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. 
  • Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. 
  • Essential role of LAT in T cell development. 
  • Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica. 
  • Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma. 
  • Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. 
  • Expression of genes for non-collagenous proteins during embryonic bone formation. 
  • Expression of nonphagocytic NADPH oxidase system in the ocular lens. 
  • Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass. 
  • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. 
  • Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. 
  • Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart. 
  • First- and third-generation epidermal growth factor receptor inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatological reactions. 
  • Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin. 
  • Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. 
  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. 
  • GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Genetic variants in GTF2H1 and risk of lung cancer: a case-control analysis in a Chinese population. 
  • Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. 
  • Genetics. Enhancing gene regulation. 
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 
  • Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. 
  • Giant two-dimensional gel electrophoresis: methodological update and comparison with intermediate-format gel systems. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • HNF-4alpha: from MODY to late-onset type 2 diabetes. 
  • Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma. 
  • High on-treatment platelet reactivity assessed by various platelet function tests: is the consensus-defined cut-off of VASP-P platelet reactivity index too low? 
  • Histamine stimulates calcium-mediated protein phosphorylation in a colonic epithelial cell line. 
  • Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Human erythrocyte spectrin: phosphorylation in intact cells and purification of the 32P-labeled protein in a non-aggregated state. 
  • IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. 
  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. 
  • IFI16-STING-NF-κB signaling controls exogenous mitochondrion-induced endothelial activation. 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM. 
  • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Identifying phosphoCTD-associating proteins. 
  • Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis. 
  • Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT. 
  • Improving SARS-CoV-2 structures: Peer review by early coordinate release. 
  • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. 
  • Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Influence of platelet reactivity on BARC classification in East Asian patients undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study. 
  • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 
  • Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program. 
  • Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle. 
  • Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. 
  • Insulin receptor substrate-1 (IRS-1) expression in rat brain. 
  • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. 
  • Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. 
  • Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Investigation of phosphoprotein signatures of archived prostate cancer tissue specimens via proteomic analysis. 
  • Involvement of linker for activation of T cells in the costimulatory signaling pathways. 
  • Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes. 
  • Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. 
  • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. 
  • Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. 
  • LAB: a new membrane-associated adaptor molecule in B cell activation. 
  • LAT is essential for Fc(epsilon)RI-mediated mast cell activation. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. 
  • LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. 
  • LAT-mediated signaling in CD4+CD25+ regulatory T cell development. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes. 
  • Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. 
  • Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. 
  • Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. 
  • Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. 
  • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Localization of Phosphoproteins within the Barnacle Adhesive Interface. 
  • Localization of the mouse gene for secreted phosphoprotein 1 (Spp-1) (2ar, osteopontin, bone sialoprotein 1, 44-kDa bone phosphoprotein, tumor-secreted phosphoprotein) to chromosome 5, closely linked to Ric (Rickettsia resistance). 
  • Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination. 
  • Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. 
  • Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. 
  • Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data. 
  • Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice. 
  • Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. 
  • Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. 
  • Molecular editing of cellular responses by the high-affinity receptor for IgE. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. 
  • Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. 
  • Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. 
  • Myelin basic protein phosphatase activity in rat brain. 
  • Myosin III illuminates the mechanism of arrestin translocation. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • N-terminal PDZ domain is required for NHERF dimerization. 
  • NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. 
  • NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. 
  • NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. 
  • NHERF-1 is required for renal adaptation to a low-phosphate diet. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. 
  • NHERF: targeting and trafficking membrane proteins. 
  • Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit. 
  • Need radioprotection? A MEPE/OF45 mimetic may do the job. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. 
  • Nomenclature: vertebrate mediators of TGFbeta family signals. 
  • Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. 
  • OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding. 
  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. 
  • Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. 
  • Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. 
  • Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. 
  • Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. 
  • Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. 
  • Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. 
  • Phosducin, potential role in modulation of olfactory signaling. 
  • Phosphatases driving mitosis: pushing the gas and lifting the brakes. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. 
  • Phosphoproteome analysis in yeast. 
  • Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. 
  • Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation. 
  • Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure. 
  • Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor. 
  • Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. 
  • Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. 
  • Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. 
  • Physiologic importance of protein phosphatase inhibitors. 
  • Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 
  • Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate. 
  • Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. 
  • Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients. 
  • Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein phosphatase regulation by endogenous inhibitors. 
  • Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. 
  • RAP2 mediates mechanoresponses of the Hippo pathway. 
  • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. 
  • Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosis. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Real-world diagnostic testing patterns for assessment of ring sideroblasts and SF3B1 mutations in patients with newly diagnosed lower-risk myelodysplastic syndromes. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells. 
  • Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Regulated expression of p18, a major phosphoprotein of leukemic cells. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of hematopoietic cell development and activation by adapter proteins. 
  • Regulation of ion transport by the NHERF family of PDZ proteins. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. 
  • Regulation of the Na/H exchanger regulatory factor in OK cells. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in East Asian patients after high-dose clopidogrel loading. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • Robust control of mitotic spindle orientation in the developing epidermis. 
  • Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. 
  • Role of NHERF and scaffolding proteins in proximal tubule transport. 
  • Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies. 
  • Role of eotaxin-1 signaling in ovarian cancer. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells. 
  • Selective modification of antigen-specific T cells by RNA electroporation. 
  • Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. 
  • Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. 
  • Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. 
  • Signaling by wingless in Drosophila. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. 
  • Standardization of cytokine flow cytometry assays. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Statin, a protein specifically present in nonproliferating cells, is a phosphoprotein and forms a complex with a 45-kilodalton serine/threonine kinase. 
  • Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Studies of the phosphoenzyme intermediate of the yeast plasma membrane proton-translocating ATPase. 
  • Studies on the adapter molecule LAT. 
  • Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. 
  • Synergistic roles for lipids and proteins in the permanent adhesive of barnacle larvae. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control. 
  • TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. 
  • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. 
  • Targeting nucleolin for better survival in diffuse large B-cell lymphoma. 
  • Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. 
  • Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. 
  • The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression. 
  • The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. 
  • The Na-H exchanger regulatory factor. 
  • The aged niche disrupts muscle stem cell quiescence. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. 
  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The dishevelled protein is modified by wingless signaling in Drosophila. 
  • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. 
  • The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments. 
  • The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The importance of LAT in the activation, homeostasis, and regulatory function of T cells. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. 
  • The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. 
  • The junctional complex of the membrane skeleton. 
  • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. 
  • The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia. 
  • The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. 
  • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. 
  • Transmembrane adaptor proteins: organizers of immunoreceptor signalling. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. 
  • Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. 
  • Tyrosine phosphorylation in human neutrophil. 
  • Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 
  • Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. 
  • Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. 
  • Use of okadaic acid to inhibit protein phosphatases in intact cells. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
  • YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction. 
  • beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 
  • beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • cAMP-dependent regulatory processes in the acquisition and control of sperm flagellar movement. 
  • cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription. 
  • p63 expression profile in normal and malignant prostate epithelial cells. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • β-Arrestin and dishevelled coordinate biased signaling. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology