Phosphotransferases

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  Subject Areas on Research

  • A bacterial kinase phosphorylates OSK1 to suppress stomatal immunity in rice. 
  • A biochemical genetic study of the role of specific nucleoside kinases in deoxyadenosine phosphorylation by cultured human cells. 
  • A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic. 
  • A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. 
  • Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes. 
  • Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels. 
  • Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins. 
  • Biochemical analysis of inositol phosphate kinases. 
  • Caspases and kinases in a death grip. 
  • Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum. 
  • Circular RNAs are abundant, conserved, and associated with ALU repeats. 
  • Cytokinetic and molecular pharmacology studies of arabinosylcytosine in metastatic melanoma. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. 
  • Elucidation of aberrant purine metabolism: application to hypoxanthine-guanine phosphoribosylstransferase- and adenosine kinase-deficient mutants, and IMP dehydrogenase- and adenosine deaminase-inhibited human lymphoblasts. 
  • Evidence that the src gene product of Rous sarcoma virus is membrane associated. 
  • FERONIA Receptor Kinase Contributes to Plant Immunity by Suppressing Jasmonic Acid Signaling in Arabidopsis thaliana. 
  • FERONIA restricts Pseudomonas in the rhizosphere microbiome via regulation of reactive oxygen species. 
  • Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity. 
  • Feedback control of T-cell receptor activation. 
  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 
  • Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. 
  • Genotype-phenotype correlation of congenital anomalies in multiple congenital anomalies hypotonia seizures syndrome (MCAHS1)/PIGN-related epilepsy. 
  • Heterogeneity of glycolysis in cancers and therapeutic opportunities. 
  • Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism. 
  • Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus. 
  • Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana. 
  • Integrating diagnostics and therapeutics: revolutionizing drug discovery and patient care. 
  • Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes. 
  • Large-scale profiling of Rab GTPase trafficking networks: the membrome. 
  • Modulation of inositol phospholipid metabolism by polyamines. 
  • Molecular basis of the biological function of molybdenum. Developmental patterns of sulfite oxidase and xanthine oxidase in the rat. 
  • Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • Ontogenesis of myosin light chain phosphorylation in guinea pig tracheal smooth muscle. 
  • Phosphatases join kinases in DNA-damage response pathways. 
  • Phosphatidylinositol kinase type I activity associates with various oncogene products. 
  • Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria. 
  • Phytochrome control of maize leaf inorganic pyrophosphatase and adenylate kinase. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT). 
  • Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. 
  • Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation. 
  • S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin. 
  • Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a. 
  • Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. 
  • Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute